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TY  - JOUR
ID  - 88301910
TI  - Refining risk assessment of Ochratoxin A through applicable toxicologic experimentation
AU  - Mantle, Peter George
KW  - ochratoxin A KW  - carcinogenicity KW  - genotoxicity KW  - DNA adducts KW  - risk assessment KW  - Ochratoxin A is primarily a nephrotoxin in many animal species but it is also a renal carcinogen in aging rats given the compound over many months. Potential carcinogenicity is the principal consideration in risk assessment for human exposure in food. Whether or not the mycotoxin is itself genotoxic by binding to DNA is an important factor in determining acceptable contamination of foodstuffs. A current European research programme seeks to clarify the question 14 14 of genotoxicity through detection of any C found bound to renal DNA of rats given C ochratoxin A of high specific radioactivity. This approach is complemented by study of gene expression changes in rat kidney during chronic exposure to a tumourogenic regime of ochratoxin A KW  - thereby pointing positively to active toxicologic influences leading to the carcinomas
RP  - IN FILE
SP  - 81
EP  - 86
T2  - Revista Mexicana de Micología
VL  - 19
LA - Inglés
PY  - 2004
Y1  - 2004
Y2  - 2017/12/13
SN  - 0187-3180
UR  - http://www.redalyc.org/articulo.oa?id=88301910
AB  - Ochratoxin A is primarily a nephrotoxin in many animal species but it is also a renal carcinogen in aging rats given the compound over many months. Potential carcinogenicity is the principal consideration in risk assessment for human exposure in food. Whether or not the mycotoxin is itself genotoxic by binding to DNA is an important factor in determining acceptable contamination of foodstuffs....
DB  - Redalyc
ER  -
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