We present the evolution of production scientific journals indexed in the Web of Science, researchers from institutions in the province of Holguin, Cuba through cooperation with researchers institutions from other countries. It also determines the level of relationship and influence of interagency cooperation growth of scientific production Holguin academics in stage
between 1980 and 2009, both inclusive. Methods is used as a scientometric study of all items magazines published in WoS by researchers from institutions located in the province of Holguín, in the period selected for the research; so that combined techniques scientometric analysis techniques social networks. Countries are presented the most collaborating researchers Holguín institutions. As aspects conclusive, international cooperation conditions the increase in production Holguín scientific researchers and cooperation. Results provide information to draw policy Scientific management of science in Holguín province.