Objective: To determine the prevalence and factors associated with alcohol and tobacco students of Food Science and Nutrition from a university in Lima. Methods: A cross sectional study was conducted during April 2010, we applied a modified version of the survey on habits and attitudes towards the consumption of psychoactive substances in university students from Lima, participated all students of this career who were on days of the survey. We performed univariate statistics, bivariate and multivariate analysis with a confidence level of 95%. Results: We interviewed a total of 250 students, the prevalence of recent alcohol consumption was 42.8% and were independent factors associated with male gender (OR = 2.7, CI=95% 1.4 - 4.8), Regular self-perception of academic achievement (OR = 2.1, CI=95% 1.2 -3.5) and household consumption of alcohol and snuff at parties and gatherings (OR = 2.7, CI= 95% CI: 1.5 - 4.8). The prevalence of recent use of tobacco was 28.4% and were independent factors associated with male gender (OR = 2.4, CI=95% 1.1 - 5.4), self-perception of mediocre academic achievement (OR = 2.1, CI=95% 1.2 to 3.8), household consumption of alcohol and tobacco at parties and gatherings (OR = 2.4, CI=95% 1.2-4.8) and age greater than 20 years (OR = 1.9, CI=95% 1.1 - 3.4). Conclusions: The prevalence of alcohol and tobacco in this population is at the intermediate level previously reported in university students; male sex and self-perception of mediocre academic achievement are the most important factors leading to the recent use of alcohol.