The aim of the current study was to determine the relationship between levels of depression and perceived quality of life based on the level of physical activity in patients with fibromyalgia in Seville (Spain). A total of 67 women diagnosed with fibromyalgia voluntarily participated in the study. The level of physical activity was assessed using the International Questionnaire of Physical Activity, the incidence of depression was assessed using the Beck Depression Inventory and their perceived quality of life using the SF-36. Significant differences between physical function and general health based on the depression categories in those with a moderate level of physical activity were found. In addition, high correlations were found between levels of depression and physical functioning
(r = -.409, p < .05), general health (r = -.453, p < .05) and mental health (r = -.539, p < .05) among the participants. In conclusion, given the close relationship between depression and the perceived quality of life and the ability of physical activity to modulate these relationships in fibromyalgia patients, professionals should establish prevention strategies based on the promotion of physical activity to help improve health in this population.