Objectives: Cross-sectional study to assess the prevalence, distribution and variables associated of caries among Dominican adolescents. Materials and Methods: A random sample of 982 Dominican adolescents (aged 12-21) was obtained in 26 schools and 106 classes. A probability weighted sample was selected using a complex, multistage probability sampling design. Subjects were clinically examined under field conditions by a single calibrated examiner. Caries were diagnosed using the current World Health Or- ganization (WHO) criteria. Results: The mean DMFT index was 8.52 ± 4.89 and SiC was 14 for the entire sample. A multiple linear regression model identified factors associated with the high caries experience of adolescents and found that caries were associated with age and gender. Female adolescents had more decayed teeth, more missing teeth and more filled teeth than male adolescents. The overall proportion of caries-free adolescents was 9.98 percent and only 5.7 percent never had a caries lesion. The first molar teeth had the greatest caries experience, > 70% and the dental damage had symmetrical distribution. Conclusions: Caries lesions are a common and with high prevalence disease in adolescents in Santo Domingo, Dominican Republic. The prevalence of caries was similar and symmetric in both sides of the mouth, so in maxillary as in mandibular teeth. Caries were higher in first and second molars. Only age and gender increased the probability to present caries lesions.