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Genotoxic potential of inhalation of "All Outw (AO), a liquid mosquito repellent, vapour (AOV) was evaluated in target (pulmonary alveolar macrophages or PAMs) and non-target (bone marrow or BM) ce11s of rats. Evaluation was based on analysis of chromosome aberrations (CAs) in PAMs and BM cells, and micronuclei (MN) in PAMs. The rats were exposed to static vapour intermiíiently in a closed inhalation chamber (15 miníh, 8 híday) for short-term (1 day) exposure and (15 minlh, 8 híday, 7 dayl week) for long-term (7 days) exposure. Animals were killed 24 h and 32 h af€er the final exposure for CA and MN studies respectively. Concentration-response analysis done by exposing the animals in AOV collected for different periods (1, 5 and 10 min) for both CAs and MN showed a good positive correlation; significantly higher frequencies, compared to the respective controls, of CAs and MN were obtained for the highest concentration tested. In no case the incidence of CAs in BM cells differed significantly from the control value. Insecticide present in A0 is supposed to be responsible for causing chromosome damage. Differential response of PAMs and BM cells has been discussed from the point of target and non-Wrget cells. Lack of any remarkable difference in effect for 1 and 7 day exposures seems to be due to the proliferative nature of the cells.

Palabras clave: mosquito repellent, "M Out", genotoxic effect, puimonary alveolar macrophages, chromosome aberrations, micronucleus
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Universidad Autónoma del Estado de México
Sistema de Información Científica Redalyc ®
Versión 3.0 | 2017
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