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DDT¿S, HCH AND HCB LEVELS IN BREAST ADIPOSE TISSUE IN WOMEN WITH BREAST TUMORS
Stefan M. Waliszewski, Marco T. Bermudez, Carmen S. Silva, Rosa M. Infanzon, Octavio Carvajal, Sandra Gomez Arroyo, Rafael Villalobos Pietrini, Patricia Trujillo, Vicente Saldaña, Guadalupe Melo, Sergio Esquivel, Felipe Castro, Héctor Ocampo, J. Torres, Patricia M. Hayward-Jones;
Revista Internacional de Contaminación Ambiental 2005 21(3)
Resumen
Inglés Español
Organochlorine pesticides have been used in Mexico in agriculture, sanitation, malaria programs and livestock to combat ectoparasites. Due to their chemical stability, persistence and lipophility, their residues bioconcentrate in lipidrich tissues, according to the equilibrium pattern of internal transport and lipid tissue content. The studies on their role as estrogenic or antiandrogenic agents have related these pesticides to breast cancer. Therefore, organochlorine pesticides were determined in breast adipose tissue of women subjected to surgery due to the diagnosis of breast abnormalities. The study pool constituted 127 women with malignant breast tumors, 127 with benign breast tumors and 127 in a control group without breast abnormalities. The pesticides determined were: HCB, bHCH, pp’DDE, op’DDT, pp’DDT andSDDT. Comparing the studied groups, the highest residue levels were determined in the benign breast tumor group. The determined levels from the control group through malignant to benign cases increased stepwise; HCB: 0.045, 0.099, 0.116 mg kg 1 ,bHCH: 0.163, 0.265, 0.319 mg kg 1 , pp’DDE: 0.782, 0.980, 1.761 mg kg 1 , op’DDT: 0.035, 0.094, 0.176 mg kg 1 , pp’DDT: 0.296, 0.351, 0.661 mg kg 1 ,SDDT: 1.112, 1.423, 2.601 mg kg 1 , respectively. Paired analyses of the three groups revealed divergences among them and correlation of these pesticide levels with breast tumors. Calculated relative risk (RR) values for the benign to control group and the malignant to control cases presented the following values: HCB: 2.11, 2.01, bHCH: 1.96, 1.58, pp’DDE: 2.13, 1.17, op’DDT: 4.42, 2.27, pp’DDT: 2.33, 1.33, SDDT: 2.21, 1.19 respectively. The obtained results indicate higher organochlorine pesticide residue levels in women with benign breast abnormalities and higher relative risk related to op’DDT presence.

Palabras clave: pesticides, breast tumors
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Universidad Autónoma del Estado de México
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