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Sistema de Información Científica Redalyc
Red de Revistas Científicas de América Latina y el Caribe, España y Portugal

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The influence of non-scientific factors on risk-assessment in the regulatory context is discussed. On the purely technical level, most controversy when dealing with data interpretation has been centered around certain types of tumors caused by exposure to non-genotoxic agents in the rodent, and which many scientists consider to be of doubtful relevance to man. The reasons for decreased reliance on such toxicological findings are high spontaneous background levels and/or mechanistic considerations. Such tumors include target organs like liver, bladder, forestomach, renal tubuli, as well as certain endocrine associated tumors, like those of the thyroid, mammary glands, pituitary, and adrenal glands (phaeochromocytomas). While discussing examples of controversial experimental carcinogens, the assessment by international organizations as well as regulatory decisions made by different national agencies in Europe and North America are presented.

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Universidad Autónoma del Estado de México
Sistema de Información Científica Redalyc ®
Versión 3.0 | 2017
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