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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">clinsa</journal-id>
            <journal-title-group>
                <journal-title>Clínica y Salud</journal-title>
                <abbrev-journal-title abbrev-type="publisher">Clínica y Salud</abbrev-journal-title>
            </journal-title-group>
            <issn pub-type="ppub">1130-5274</issn>
            <publisher>
                <publisher-name>Colegio Oficial de la Psicología de Madrid</publisher-name>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.5093/clysa2020a24</article-id>
            <article-id pub-id-type="other">00004</article-id>
            <article-id pub-id-type="publisher-id">00004</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>research-article</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Effects of a Mindfulness Program for University Students</article-title>
                <trans-title-group xml:lang="es">
                    <trans-title>Los efectos de un programa de mindfulness en estudiantes universitarios</trans-title>
                </trans-title-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Moix</surname>
                        <given-names>Jenny</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Cladellas</surname>
                        <given-names>Marta</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01b"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Gayete</surname>
                        <given-names>Sílvia</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01c"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Guarch</surname>
                        <given-names>Marina</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01d"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Heredia</surname>
                        <given-names>Irina</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01e"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Parpal</surname>
                        <given-names>Guillem</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01f"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Toledo</surname>
                        <given-names>Alicia</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01g"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Torrent</surname>
                        <given-names>David</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01h"/>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Trujillo</surname>
                        <given-names>Adria</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01i"/>
                </contrib>
            </contrib-group>
            <aff id="aff01">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01b">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01c">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01d">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01e">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01f">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01g">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01h">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <aff id="aff01i">
                <institution content-type="orgname">Universidad Autónoma de Barcelona</institution>
                <institution content-type="normalized">Universidad Autónoma de Barcelona</institution>
                <addr-line>
                    <named-content content-type="city">Barcelona</named-content>
                </addr-line>
                <country country="ES">Spain</country>
                <institution content-type="original">Universidad Autónoma de Barcelona, Spain</institution>
            </aff>
            <author-notes>
                <corresp id="c01">Correspondence: <email>Jenny.moix@uab.cat</email> (J. Moix)</corresp>
                <fn fn-type="conflict" id="fn01">
                    <label><bold>Conflict of Interest:</bold></label>
                    <p> the authors of this article declare no conflict of interest.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub-ppub">
                <month>1</month>
                <year>2021</year>
            </pub-date>
            <volume>32</volume>
            <issue>1</issue>
            <fpage>23</fpage>
            <lpage>28</lpage>
            <history>
                <date date-type="received">
                    <day>10</day>
                    <month>01</month>
                    <year>2020</year>
                </date>
                <date date-type="accepted">
                    <day>23</day>
                    <month>07</month>
                    <year>2020</year>
                </date>
                <date date-type="pub">
                    <day>16</day>
                    <month>09</month>
                    <year>2020</year>
                </date>
            </history>
            <permissions>
                <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/" xml:lang="en">
                    <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.</license-p>
                </license>
            </permissions>
            <abstract>
                <title>ABSTRACT</title>
                <p>The aim of this study was to determine the effectiveness of a brief and flexible mindfulness program in reducing anxiety and increasing mindful awareness in psychology university students. The sample consisted of 72 psychology students who participated in four different studies. The first was a quasi-experimental study and the remaining three studies were randomized controlled trials (RCT). A mindfulness program was applied to intervention groups. Anxiety (STAI-T) and mindful awareness (FFMQ) were assessed before and immediately after the intervention. Anxiety was reduced and mindful awareness increased in the intervention groups (<italic>p</italic> &lt; .05). In the three RCTs the magnitude of change (between groups) showed a moderate increase in mindful awareness in one study (<italic>d</italic> = 0.68) and a large increase in the remaining two (<italic>d</italic> = 1.32, 1.01), and as regards anxiety, large changes were observed in the three studies (<italic>d</italic> = 0.80, 1.04, 0.81). As a conclusion, this mindfulness program proved to be effective in reducing anxiety and increasing mindful awareness.</p>
            </abstract>
            <trans-abstract xml:lang="es">
                <title>RESUMEN</title>
                <p>El objetivo de este estudio es determinar la eficacia de un programa de <italic>mindfulness</italic> breve y flexible para reducir la ansiedad y aumentar la conciencia plena en los estudiantes universitarios de psicología. La muestra comprende 72 estudiantes de psicología que participaron en cuatro estudios diferentes. El primero fue cuasi-experimental y los tres restantes fueron ensayos controlados aleatorizados (en inglés, RCT). Se aplicó un programa de <italic>mindfulness</italic> a los grupos de intervención. La ansiedad (STAI-T) y la conciencia plena (FFMQ) se evaluaron antes e inmediatamente después de la intervención. Se redujo la ansiedad y se incrementó la conciencia plena en los grupos de intervención (<italic>p</italic> &lt;. 05). En los tres RCT la magnitud del cambio (entre grupos) mostró un aumento moderado de la conciencia plena en un estudio (<italic>d</italic> = 0.68) y un gran aumento de los dos restantes (<italic>d</italic> = 1.32, 1.01) y en lo que respecta a la ansiedad se observaron grandes cambios en los tres estudios (<italic>d</italic> = 0.80, 1.04, 0.81). Como conclusión, este programa de <italic>mindfulness</italic> demostró su eficacia en la reducción de la ansiedad y el aumento de la conciencia plena.</p>
            </trans-abstract>
            <kwd-group xml:lang="en">
                <title>Keywords:</title>
                <kwd>Anxiety</kwd>
                <kwd>Mindfulness</kwd>
                <kwd>Mindful awareness</kwd>
                <kwd>University students</kwd>
            </kwd-group>
            <kwd-group xml:lang="es">
                <title>Palabras clave:</title>
                <kwd>Ansiedad</kwd>
                <kwd>
                    <italic>Mindfulness</italic>
                </kwd>
                <kwd>Atención plena</kwd>
                <kwd>Estudiantes universitarios</kwd>
            </kwd-group>
            <counts>
                <fig-count count="0"/>
                <table-count count="7"/>
                <equation-count count="0"/>
                <ref-count count="22"/>
            </counts>
        </article-meta>
    </front>
    <body>
        <sec sec-type="intro">
            <title>Introduction</title>
        <p>Evidence of the effectiveness of mindfulness programs is constantly increasing (<xref ref-type="bibr" rid="B14">Garcia-Campayo &amp; Demarzo, 2018</xref>; <xref ref-type="bibr" rid="B19">Miró et al., 2011</xref>). <xref ref-type="bibr" rid="B16">Kabat-Zinn (1994)</xref> defines mindfulness as the awareness that springs from paying intentionally attention to experience exactly as it is perceived in the present moment, without judging it, without evaluating it, and without reacting to it. One of the fields in which the effectiveness of mindfulness programs is being demonstrated is the university setting (<xref ref-type="bibr" rid="B05">Bruin et al., 2015</xref>; <xref ref-type="bibr" rid="B09">De Vibe et al., 2013</xref>; <xref ref-type="bibr" rid="B11">Fuente-Arias et al., 2010</xref>; <xref ref-type="bibr" rid="B13">Gallego et al., 2014</xref>; <xref ref-type="bibr" rid="B15">Hindman et al., 2015</xref>; <xref ref-type="bibr" rid="B18">McConville et al., 2017</xref>; <xref ref-type="bibr" rid="B22">Yagüe et al., 2016</xref>).</p>
        <p>Reduction of anxiety is one of the most observed benefits, and as such it is essential that mindfulness programs must be introduced into the academic field, since students—especially those in their first year—present high levels of anxiety (<xref ref-type="bibr" rid="B02">Balanza et al., 2009</xref>; <xref ref-type="bibr" rid="B03">Bayram &amp; Bilgel, 2008</xref>; <xref ref-type="bibr" rid="B04">Bewick et al., 2010</xref>; <xref ref-type="bibr" rid="B06">Cardona-Arias et al., 2015</xref>; <xref ref-type="bibr" rid="B17">Martínez-Otero, 2014</xref>).</p>
        <p>The aim of this research was to design and determine the effectiveness of a mindfulness program for first-year university students, based on three premises:</p>
        <list list-type="order">
            <list-item>
                <p>One of the reasons why students suffer from anxiety is lack of time. Nevertheless, programs often tend to take several weeks to complete. In the review carried out by <xref ref-type="bibr" rid="B18">McConville et al. (2017)</xref>, 13 out of 18 studies assessed consisted of 8 o more sessions. In light of this, a brief program was designed, requiring only three sessions for completion.</p>
            </list-item>
            <list-item>
                <p>Program effectiveness depends not only on the protocol itself, but also on how suitable this is as regards participants and instructors. A need for adaptable and flexible programs comes from this. Other studies have shown a need to adapt mindfulness programs for university students by including flexible elements in their sessions (<xref ref-type="bibr" rid="B12">Galante et al., 2018</xref>). A flexible program was therefore designed, in which a certain part of the protocol could be fully adapted to these characteristics, varying each time it was applied with different instructors and participants.</p>
            </list-item>
            <list-item>
                <p>Focusing on a protocol may involve leaving the conceptual foundation of the program (<xref ref-type="bibr" rid="B20">Moix &amp; Carmona, 2018</xref>). Consequently, the theoretical framework was highlighted. This consisted of the conception set out by <xref ref-type="bibr" rid="B01">Baer et al. (2006)</xref>, which sees mindfulness as a set of five capacities: observing, describing, acting with awareness, non-judgement, and non-reactivity. The protocol was designed to specifically treat these five capacities in order to increase them.</p>
            </list-item>
        </list>
        <p><xref ref-type="bibr" rid="B01">Baer et al. (2006)</xref> administered five mindfulness questionnaires to two large samples of undergraduate students. Factor analyses from these questionnaires suggested that collectively they contain five facets of mindfulness: “observing”, referring to a subject’s ability to observe not only external stimuli (visual, auditory, tactile, etc.) but also to observe the effect of one’s emotions on thought and behavior; “describing”, referring to the ability to find suitable words to express feelings, sensations, and experiences; “acting with awareness”, which is the ability to be present—and not on ‘autopilot’—when performing any activity; “non-judgement”, referring to the ability not to judge one’s own emotions and thoughts; and, finally, “non-reactivity”, being the ability not to act reflexively or instantly when experiencing certain thoughts or emotions.</p>
        <p>Making up a protocol based on the premises of short duration, flexibility, and guidance through the conception set out by <xref ref-type="bibr" rid="B01">Baer et al. (2006)</xref> is a new approach that can help to introduce mindfulness within the university environment to a far greater extent than is currently the case.</p>
        <p>More particularly, and bearing in mind the above considerations, the objective was to determine the effectiveness of a brief and flexible program based on the proposal of the five factors established by <xref ref-type="bibr" rid="B01">Baer et al. (2006)</xref> in order to reduce anxiety and increase mindful awareness.</p>            </sec>
        <sec sec-type="methods">
            <title>Method</title>
            <sec>
                <title>Participants</title>
                <p>A total of 72 students participated in the global study. This consisted of a pilot quasi-experimental study without a control group and three experimental studies with a control group. In the three experimental studies, the participants were randomly assigned to the intervention group or the control group, balancing gender variable. All participants in the intervention groups completed the program. In the control groups, a total of three participants dropped out because of incompatibility with other activities.</p>
                <p>All participants were first-year psychology students and the only criterion of exclusion was having previous experience in meditation.</p>
                <p>The age and gender of all participants in the four studies are described in <xref ref-type="table" rid="t01">Table 1</xref>. There were no significant differences between intervention and control groups.</p>
                <p>
                <table-wrap id="t01">
                    <label>Table 1</label>
                    <caption>
                        <title>Mean Age (<italic>SD</italic>) Values and Number of Female and Male Participants in Intervention and Control Groups</title>
                    </caption>
                    <graphic xlink:href="1130-5274-clinsa-32-1-0023-gt01.jpg"/>
                </table-wrap>
            </p>
            </sec>
            <sec>
                <title>Instruments</title>
                <p>The Spanish version of the two questionnaires was administered.</p>
                <p><bold>Trait scale of the State-Trait Anxiety Inventory</bold> (STAI; <xref ref-type="bibr" rid="B21">Spielberger et al., 1982</xref>). This scale contains 20 items with a Likert scale of 0-3 points. It presents a good test-retest reliability index (.87) and a high internal consistency (α = .90). Trait anxiety scores can range from 0 to 60 points. High scores indicate high anxiety.</p>
                <p><bold>Five Facet Mindfulness Questionnaire</bold> (FFMQ; <xref ref-type="bibr" rid="B01">Baer et al., 2006</xref>). This instrument evaluates personal disposition of awareness to daily life. It consists of 39 items grouped into five factors: observing, describing, acting with awareness, non-judgement, and non-reactivity. Validation of the Spanish version (<xref ref-type="bibr" rid="B07">Cebolla, et al., 2012</xref>) shows that the internal reliability of the scales ranges from acceptable to very good and that factor structure is the same as factor structure proposed by <xref ref-type="bibr" rid="B01">Baer et al. (2006)</xref>. The first four dimensions are scored from 0 to 40 and the last (non-reactivity) is scored from 0 to 35. High scores indicate high mindfulness capacity.</p>
                <p><bold>Semi-structured interview.</bold> To obtain qualitative information from the intervention groups, a one-hour interview was conducted. The interview started with an initial question: “How do you feel compared to how you were before the program?”. Changes concerning “anxiety” and “mindful awareness” variables were discussed during the interview.</p>
            </sec>
            <sec>
                <title>Procedure</title>
                <p>Psychology students at the Universitat Autònoma de Barcelona (UAB), Spain, were recruited in four waves (2015/16, 2016/17, 2017/18, and 2018/19 academic years). Participation in the study was completely voluntary and there were no financial or academic incentives for participation. Once the nature of the study had been explained, participants signed an informed consent. The confidential and voluntary nature of participation was respected at all times. The study was adjusted to the ethical regulations of the degree-final projects at the UAB Faculty of Psychology. Once the research was completed, the possibility of attending the mindfulness program was offered to control groups subjects.</p>
                <p>The pilot study (2015/2016 academic year) used a quasi-experimental pre-post design without a control group. The next three studies used a 2 (group: intervention, control) by 2 (time: baseline, post-treatment) mixed design with “group” as a between-subjects variable and “time” as a within-subjects factor. Intervention groups received the mindfulness program. The control groups did not receive any treatment. In the two groups, baseline assessment was carried out before the first session of the mindfulness program and post-treatment assessment was carried out three weeks later, immediately after completion of the program.</p>
            </sec>
            <sec>
                <title>Mindfulness Program</title>
                <p>The mindfulness program consisted of three 120-minute weekly group sessions. The content of each session was focused on a different facet (<xref ref-type="bibr" rid="B01">Baer et al., 2006</xref>): observing, describing, acting with awareness, non-judgement, and non-reactivity. Homework consisted mainly of: a seated meditation with focus on breathing (5 min), mindfulness of routine activity, and ‘three gifts’ exercise (acknowledge three pleasant moments in the day).</p>
                <p>The groups were led by three instructors. The main instructor for the program in the four studies was an expert in mindfulness who practised meditation regularly; the two assistant instructors were different in each study. The assistant instructors were psychology students in the last year of their degree and had been previously trained.</p>
                <p>
                <table-wrap id="t02">
                    <label>Table 2</label>
                    <caption>
                        <title>Specific Session Content and Structure</title>
                    </caption>
                    <graphic xlink:href="1130-5274-clinsa-32-1-0023-gt02.jpg"/>
                </table-wrap>
            </p>
                <p>The structure of the mindfulness program was the same throughout the four studies (<xref ref-type="table" rid="t02">Table 2</xref>). This fixed part of the program was carried out by the main instructor. Program flexibility was attained by allowing the assistant instructors—who were different in each study—to propose and take charge of certain exercises. For example, a musician played the piano in one of the studies to facilitate work on the “observing” scale by means of the music; in another, a painting was used with a similar goal.</p>
                <p>Between the sessions, images with phrases related to the topics worked on were sent through WhatsApp to the whole group. This component of the program was also flexible, as these messages varied in each study. The phrases were chosen by the assistant instructors based on what the participants had expressed during the sessions.</p>
            </sec>
            <sec>
                <title>Data Analysis</title>
                <sec>
                    <title>STATA 13.1. for Windows was used.</title>
                    <p>To determine the effect of the program in the intervention group (of the four studies) the paired sample Students’ t-test was used. Normal distribution between pre and post changes was checked for. In the few cases where distribution was not normal, the Wilcoxon non-parametric test was used.</p>
                    <p>To determine the presence of significant differences in the pre-post changes between the experimental and control groups (for the three experimental studies), the independent-sample Student’s <italic>t</italic>-test was used. Homogeneity of variance and normal distribution in all analyses was checked for. Distribution was normal in all cases. As regards homogeneity of variance, in the few cases that this was not observed, the Welch test was used.</p>
                    <p>The clinical significance of observed changes within and between groups was assessed using effect-size estimates (Cohen’s <italic>d</italic>).</p>
                    <p>As regards qualitative analysis, an interpretative subject analysis was performed on the information collected from the semi-structured interviews held for the intervention group. First, all interviews were transcribed and read in their entirety. Second, the information relating to the two main variables (anxiety and mindful awareness) was codified and organized. Subsequently, quotations that most represented the variables were selected. To improve rigor, a triangulation of the analysis was carried out by three researchers.</p>
                </sec>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <p><xref ref-type="table" rid="t03">Tables 3</xref>, <xref ref-type="table" rid="t04">4</xref>, <xref ref-type="table" rid="t05">5</xref> and <xref ref-type="table" rid="t06">6</xref> contain the results of the pilot study and of studies 1, 2, and 3, respectively.</p>
            <p>
            <table-wrap id="t03">
                <label>Table 3</label>
                <caption>
                    <title>Pilot Study. Mean (<italic>SD</italic>) Values in Pre-treatment and Post-treatmentTime Points. Differences between Means (Dif) and Size Effect (<italic>d</italic>)</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-32-1-0023-gt03.jpg"/>
                <table-wrap-foot>
                    <fn>
                        <p><italic>Note. d</italic> = values 0.2 to 0.5 represent small changes, 0.5 to 0.8 moderate changes, and &gt; 0.8 large changes.</p>
                    </fn>
                    <fn>
                        <p>*<italic>p</italic> &lt; .05.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </p>
            <p>
            <table-wrap id="t04">
                <label>Table 4</label>
                <caption>
                    <title>Study 1. Mean (<italic>SD</italic>) Values in Pre-treatment and Post-treatment Time Points in Intervention and Control groups. Differences between Means (Dif) and Size Effect (<italic>d</italic>) within Groups. Differences between Groups (Dif) and Size Effect between Groups (<italic>d</italic>)</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-32-1-0023-gt04.jpg"/>
                <table-wrap-foot>
                    <fn>
                        <p><italic>Note. d</italic> = values 0.2 to 0.5 represent small changes; 0.5 to 0.8 moderate changes, and &gt; 0.8 large changes.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </p>
            <p>
            <table-wrap id="t05">
                <label>Table 5</label>
                <caption>
                    <title>Study 2. Mean (<italic>SD</italic>) Values in Pre-treatment and Post-treatment Time Points in Intervention and Control groups. Differences between Means (Dif) and Size Effect (<italic>d</italic>) within Groups. Differences between Groups (Dif) and Size Effect between Groups (<italic>d</italic>)</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-32-1-0023-gt05.jpg"/>
                <table-wrap-foot>
                    <fn>
                        <p><italic>Note. d</italic> = values 0.2 to 0.5 represent small changes; 0.5 to 0.8 moderate changes, and &gt; 0.8 large changes.</p>
                    </fn>
                    <fn>
                        <p>*<italic>p</italic> &lt; .05.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </p>
            <p>
            <table-wrap id="t06">
                <label>Table 6</label>
                <caption>
                    <title>Study 3. Mean (<italic>SD</italic>) Values in Pre-treatment and Post-treatment Time Points in Intervention and Control groups. Differences between Means (Dif) and Size Effect (<italic>d</italic>) within Groups. Differences between Groups (Dif) and Size Effect between Groups (<italic>d</italic>)</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-32-1-0023-gt06.jpg"/>
                <table-wrap-foot>
                    <fn>
                        <p><italic>Note. d</italic> = values 0.2 to 0.5 represent small changes, 0.5 to 0.8 moderate changes, and &gt; 0.8 large changes.</p>
                    </fn>
                    <fn>
                        <p>*<italic>p</italic> &lt; .05, **<italic>p</italic> &lt; .01.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </p>
            <p>Corresponding to the quasi-experimental study, <xref ref-type="table" rid="t03">Table 3</xref> contains the median and standard deviation of each variable before and after intervention, differences, and Cohen’s <italic>d</italic>.</p>
            <p><xref ref-type="table" rid="t03">Table 3</xref> shows that significant differences exist between pre and post intervention in the two variables studied (anxiety and mindfulness). An increase can be observed in all scales of the mindfulness questionnaire, reaching a significant level for “observing” and “non-judgement”. As regards the magnitude of changes, these are moderate for anxiety and large for mindfulness.</p>
            <p>In addition to the data from intervention groups, <xref ref-type="table" rid="t04">Tables 4</xref>, <xref ref-type="table" rid="t05">5</xref>, and <xref ref-type="table" rid="t06">6</xref> contain data from control groups, differences between groups, and Cohen’s <italic>d</italic> between groups.</p>
            <p>As regards the intervention group, <xref ref-type="table" rid="t04">Table 4</xref> reveals significant changes in anxiety and mindfulness between before and after the program, with large magnitudes of change. Differences between intervention and control groups are as expected in the two variables, but only reach a significant level in mindfulness. With respect to scales of mindfulness, there are significant increases throughout, except for “non-judgement”. The fact that there are significant differences in anxiety before and after in the intervention group, but these are not encountered when the intervention group and the control group are compared, is probably due to the fact that there is also a slight reduction in anxiety in the control group. As regards magnitude of change, large changes are observed in anxiety and mindfulness.</p>
            <p>In the intervention group of study 2 (<xref ref-type="table" rid="t05">Table 5</xref>), significant changes between before and after can be observed in anxiety and mindfulness. As regards magnitude of change, this is moderate for anxiety and large for mindfulness. With respect to differences between control group and intervention group, these are significant. On the specific scales in the mindfulness questionnaire, significance is reached in “observing” and “non-reactivity”. Cohen’s <italic>d</italic> between groups shows large changes in anxiety and mindfulness.</p>
            <p>As for the intervention group in study 3 (<xref ref-type="table" rid="t06">Table 6</xref>), significant changes are observed in mindfulness, with a moderate magnitude of change. These significant changes in the mindfulness variable are also observed between control and intervention groups. Significant changes are not observed in anxiety. Cohen’s <italic>d</italic> between groups indicates large changes in anxiety and moderate changes in mindfulness.</p>
            <p>All data obtained in the four studies draw attention to the same essential pattern: mindfulness is the variable that is always affected by intervention. Intervention groups show significant differences before and after in all cases. Similarly, significant differences are found between groups. In the three experimental studies, the magnitude of change indicates a moderate increase in one study and a large increase in the other two. Within the mindfulness variable, subjects present most changes in the “observing” scale. The other scales do not change to the same extent in different studies. As regards the anxiety variable, Cohen’s <italic>d</italic> between groups from the three experimental studies indicates large changes. Significance of change in the intervention group before and after is observed for all the studies with the exception of the last, and significance between groups is observed only in study 2. In general, the results point to the fact that intervention leads to improvement, mainly in mindfulness, followed by the anxiety variable.</p>
            <p>
            <table-wrap id="t07">
                <label>Table 7</label>
                <caption>
                    <title>Quotes Referring to Each of the Variables</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-32-1-0023-gt07.jpg"/>
                <table-wrap-foot>
                    <fn>
                        <p><italic>Note</italic>. PS = pilot study; S1, S2, S3 = Study 1, 2, and 3; Su1, Su2, Su3...= Subject 1, 2, 3,...</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </p>
            <p>Another result coinciding across all three experimental studies is that no significant differences were observed in any of the scales in the control groups.</p>
            <p>As mentioned above, all participants in the intervention group were interviewed at the end of the program to provide additional information to available quantitative data.</p>
            <p>Participants from the four studies revealed that they had benefitted from the program. To analyze the subjective experience of anxiety and mindfulness more specifically, quoted observations in which subjects referred more explicitly to these variables were marked.</p>
            <p><xref ref-type="table" rid="t07">Table 7</xref> contains for each variable one of the quotes from each study by way of example.</p>
            <p>Quotes collected in <xref ref-type="table" rid="t07">Table 7</xref> are simply examples of subjective experiences from some participants. Subjective experiences are idiosyncratic in terms of their form. In other words, each participant probably lived the experience with different nuances. As such, these accounts are not generalizable. However, although the specific form of sensation experienced by each participant is unique, in its essence these experiences appear to point in the same direction, namely, a reduction in anxiety and an increase in mindful awareness.</p>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>The program designed was beneficial, as it reduced anxiety and increased mindful awareness.</p>
            <p>In the intervention group, there is a reduction in anxiety after the program. This reduction is statistically significant in three of the studies. In the three studies with a control group, a difference between groups is observed as expected but it is statistically significant in only one of them. The magnitude of change (between groups) is large in the three RCT. These data, in addition to the qualitative information extracted from the interviews, lead us to the conclusion that the program was effective in terms of reducing anxiety. In the review by <xref ref-type="bibr" rid="B18">McConville et al. (2017)</xref>, the authors perform a meta-analysis of 11 studies assessing anxiety on health-professional students. In this, effectiveness of mindfulness in reducing anxiety is demonstrated as in other studies (<xref ref-type="bibr" rid="B15">Hindman et al., 2015</xref>; <xref ref-type="bibr" rid="B22">Yagüe et al., 2016</xref>), supporting our results.</p>
            <p>As regards mindful awareness, in the four studies a significant increase is observed in the intervention group, and significant differences are observed between intervention group and control group. The magnitude of change is moderate in one study and large in the others. In the interviews, participants described several examples that reflected this increase. All this appears to indicate the effectiveness of the program in increasing mindful awareness. These results corroborate results obtained by other studies evaluating mindful awareness through the FFMQ (<xref ref-type="bibr" rid="B05">Bruin et al., 2015</xref>; <xref ref-type="bibr" rid="B15">Hindman et al., 2015</xref>; <xref ref-type="bibr" rid="B18">McConville et al., 2017</xref>).</p>
            <p>As regards the specific change in scores on the scales of mindfulness, it is observed that the scale modified to the greatest extent is “observing”, consistent with the study by <xref ref-type="bibr" rid="B08">Coo and Salanova (2017)</xref> and <xref ref-type="bibr" rid="B15">Hindman et al., (2015)</xref>. Likewise, in the research by <xref ref-type="bibr" rid="B09">De Vibe et al. (2013)</xref>, the “observing” scale was one of two that showed significant changes. These results possibly indicate that the “observing” scale assesses a willingness or greater ability to learn. Taking performance of the five scales into account, a future re-designing of the program should place more emphasis on the four remaining scales in which less of an increase is observed.</p>
            <p>It has been shown that the results point to the fact that intervention leads to improvement, mainly in mindfulness, followed by the anxiety variable. That is, some participants, despite having increased their mindfulness abilities, have not been able to reduce anxiety to the same degree. These results fit into the theoretical framework of mindfulness, as well as what is taught within the program used: to observe and accept emotions rather than to decrease them.</p>
            <p>The program consisted of three sessions only and proved to be effective. This brevity may have contributed to the fact that none of the participants dropped out of the program, as occurred in other research studies (<xref ref-type="bibr" rid="B10">Franco et al., 2011</xref>). In the research by <xref ref-type="bibr" rid="B08">Coo and Salanova (2017)</xref>, the program also consisted of three sessions and the results were similar, corroborating that programs can be both brief and effective. Such brevity may be an advantage for introducing mindfulness into highly demanding academic curricula.</p>
            <p>The program was based on a protocol that provided a certain degree of flexibility. It varied in each study and benefits were observed in all four studies. Nevertheless, we cannot assert that this characteristic was the reason for program’s effectiveness; if an identical protocol were always followed, the program might perhaps also show equally positive results. This flexibility also prevents us from knowing which specific elements in the program were responsible for its effectiveness; such a disadvantage, however, is present in any multi-component program. Authors’ subjective feeling is that this type of flexibility serves to adapt to participants’ characteristics to a greater extent, and particularly helps instructors to develop their creativity through proposing exercises. In doing so, they become more connected to the reality of the group.</p>
            <p>Structuring the program following the proposal by <xref ref-type="bibr" rid="B01">Baer et al. (2006)</xref> with regard to the five facets of mindfulness showed itself to be effective. The fact that the program follows the same structure as the questionnaire through which the dependent variable of mindfulness was measured probably contributed to obtaining these results, since the program worked directly on what it sought to change.</p>
            <p>Although the program has shown benefits, their duration in time has not been assessed, which is one of the main limitations to this current research. In future research, measurements would need to be taken at least one year after finishing the study.</p>
            <p>Even though participants in each session were invited to carry out homework, adherence was not evaluated, which is another limitation. Data on adherence could have been useful to explain differences in the benefits obtained among participants.</p>
            <p>Another limitation is the sample size of each study, which prevents us from asserting our conclusions with fuller certainty. However, we believe that having carried out four replications that produced similar results counteracts this limitation to some degree. Notwithstanding this, future studies with larger sample sizes are necessary.</p>
            <p>Regarding the flexibility of the program, even though we consider it a positive aspect, it has the inconvenient that it makes it difficult to ensure instructors’ adjustment to the protocol.</p>
            <p>Another limitation is that the sample consists mainly of women; although this is representative of psychology students at the UAB, there is the need to be cautious when generalizing results to other degrees and disciplines for which gender ratio is different.</p>
            <p>Similarly, in future research on this program it would be advisable to assess other variables relating to academic performance, since, as highlighted by other studies, this could be increased (<xref ref-type="bibr" rid="B18">McConville et al., 2017</xref>).</p>
            <p>We hope that the results of this study contribute to opening university doors to mindfulness.</p>
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