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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">clinsa</journal-id>
            <journal-id journal-id-type="nlm-ta">Clin Salud</journal-id>
            <journal-title-group>
                <journal-title>Clínica y Salud</journal-title>
                <abbrev-journal-title abbrev-type="publisher">Clin. salud</abbrev-journal-title>
            </journal-title-group>
            <issn pub-type="epub">2174-0550</issn>
            <issn pub-type="ppub">1130-5274</issn>
            <publisher>
                <publisher-name>Colegio Oficial de la Psicología de Madrid</publisher-name>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.5093/clysa2024a10</article-id>
            <article-id pub-id-type="publisher-id">00006</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>research-article</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Intolerance of Uncertainty and Fear of Childbirth: Role of Perceived Preparedness for Childbirth</article-title>
                <trans-title-group xml:lang="es">
                    <trans-title>La intolerancia a la incertidumbre y el miedo al alumbramiento: el papel que juega la preparación para el parto</trans-title>
                </trans-title-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Brekalo</surname>
                        <given-names>Maja</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01"><sup>1</sup></xref>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Kuljanac</surname>
                        <given-names>Andela</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff02"><sup>2</sup></xref>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Nakić Radoš</surname>
                        <given-names>Sandra</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01b"><sup>1</sup></xref>
                    <xref ref-type="corresp" rid="c01"/>
                </contrib>
            </contrib-group>
            <aff id="aff01">
                <label>1</label>
                <institution content-type="normalized">Catholic University of Croatia</institution>
                <institution content-type="orgname">Catholic University of Croatia</institution>
                <addr-line>
                    <named-content content-type="city">Zagreb</named-content>
                </addr-line>
                <country country="HR">Croatia</country>
                <institution content-type="original">Catholic University of Croatia, Zagreb, Croatia;</institution>
            </aff>
            <aff id="aff01b">
                <label>1</label>
                <institution content-type="normalized">Catholic University of Croatia</institution>
                <institution content-type="orgname">Catholic University of Croatia</institution>
                <addr-line>
                    <named-content content-type="city">Zagreb</named-content>
                </addr-line>
                <country country="HR">Croatia</country>
                <institution content-type="original">Catholic University of Croatia, Zagreb, Croatia;</institution>
                <email>snrados@unicath.hr</email>
            </aff>
            <aff id="aff02">
                <label>2</label>
                <institution content-type="normalized">Kindergarden Svemirko</institution>
                <institution content-type="orgname">Kindergarden Svemirko</institution>
                <addr-line>
                    <named-content content-type="city">Zagreb</named-content>
                </addr-line>
                <country country="HR">Croatia</country>
                <institution content-type="original">Kindergarden Svemirko, Zagreb, Croatia</institution>
            </aff>
            <author-notes>
                <corresp id="c01"> Correspondence: <email>snrados@unicath.hr</email> (S. Nakić Radoš). </corresp>
                <fn fn-type="conflict">
                    <label>Conflict of Interest</label>
                    <p>The authors of this article declare no conflict of interest.</p>
                </fn>
            </author-notes>
            <!--<pub-date publication-format="electronic" date-type="pub">
                 <day>27</day>
                 <month>2</month>
                 <year>2024</year>
             </pub-date>
                 <pub-date publication-format="electronic" date-type="collection">
                 <month>3</month>
                 <year>2024</year>
             </pub-date>-->
             <pub-date pub-type="epub-ppub">
                <year>2024</year>
            </pub-date>
            <volume>35</volume>
            <issue>1</issue>
            <fpage>35</fpage>
            <lpage>38</lpage>
            <history>
                <date date-type="received">
                    <day>29</day>
                    <month>05</month>
                    <year>2023</year>
                </date>
                <date date-type="accepted">
                    <day>12</day>
                    <month>01</month>
                    <year>2024</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright &#xA9; 2023, Colegio Oficial de la Psicología de Madrid</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/" xml:lang="en">
                    <license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.</license-p>
                </license>
            </permissions>
            <abstract>
                <title>ABSTRACT</title>
                <p><italic>Background:</italic> Fear of childbirth (FOC) can lead to diverse adverse outcomes for pregnant women. Personality dispositions are one of the predictors of FOC, and intolerance of uncertainty is one of them. Previous studies were inconclusive, suggesting that intolerance of uncertainty was a predictor of FOC in pregnant women. However, the underlying mechanisms of that relation are still underexamined. Therefore, this cross-sectional study aimed to examine the mediation role of perceived preparedness for childbirth in the association between intolerance of uncertainty and FOC. <italic>Method:</italic> Participants were 168 primiparous pregnant and 124 multiparous pregnant women. Women fill out the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ), Intolerance of Uncertainty Scale (IUS), and a demographic sheet while waiting for regular prenatal checkup in hospital. <italic>Results:</italic> Results showed that perceived preparedness was a full mediator between intolerance of uncertainty and FOC in primiparous women. Intolerance of uncertainty was not correlated with FOC nor preparedness in multiparous women. <italic>Conclusions:</italic> Intolerance of uncertainty predicted FOC only indirectly through lower perceived preparedness for childbirth in primiparous women. Practical implications are discussed.</p>
            </abstract>
            <trans-abstract xml:lang="es">
                <title>RESUMEN</title>
                <p><italic>Antecedentes:</italic> El miedo al parto puede acarrear consecuencias desfavorables para las mujeres gestantes. Las disposiciones de personalidad constituyen uno de los predictores del miedo al parto, una de las cuales es la incertidumbre. Hasta ahora los estudios no han sido concluyentes al indicar que la intolerancia a la incertidumbre predecía el miedo al alumbramiento en mujeres encinta. No obstante, no se han examinado suficientemente los mecanismos subyacentes a dicha relación. <italic>Método:</italic> Así, este estudio transversal se propone analizar el papel mediador que juega la preparación percibida para el parto en la asociación entre intolerancia a la incertidumbre y el miedo al parto. Han participado 168 embarazadas primíparas y 124 multíparas, que cumplimentaron el Cuestionario Wijma sobre Expectativas/Experiencia sobre el Parto, la Escala de Intolerancia a la Incertidumbre y un formulario demográfico mientras esperaban a la revisión prenatal en el hospital. <italic>Resultados:</italic> Los resultados muestran que la preparación percibida es un gran mediador de la relación entre la intolerancia a la incertidumbre y el miedo al parto en mujeres primíparas. En las mujeres multíparas la intolerancia a la incertidumbre no correlacionaba con el miedo al parto ni con la preparación para ese momento. <italic>Conclusiones:</italic> La intolerancia a la incertidumbre predijo el miedo al parto solo indirectamente a través de una menor preparación percibida para el parto en mujeres primíparas. Se comentan las implicaciones prácticas.</p>
            </trans-abstract>
            <kwd-group xml:lang="en">
                <title>Keywords</title>
                <kwd>Fear of childbirth</kwd>
                <kwd>Intolerance of uncertainty</kwd>
                <kwd>Preparedness for childbirth</kwd>
                <kwd>Pregnant women</kwd>
            </kwd-group>
            <kwd-group xml:lang="es">
                <title>Palabras clave</title>
                <kwd>Miedo al parto</kwd>
                <kwd>Intolerancia a la incertidumbre</kwd>
                <kwd>Preparación para el parto</kwd>
                <kwd>Mujeres gestantes</kwd>
            </kwd-group>
            <counts>
                <fig-count count="1"/>
                <table-count count="2"/>
                <equation-count count="0"/>
                <ref-count count="14"/>
                <page-count count="4"/>
            </counts>
        </article-meta>
    </front>
    <body>
        <sec sec-type="intro">
            <title>Introduction</title>
        <p>Fear of childbirth (FOC) can negatively impact both mothers and infants. Both nulliparous and parous women can have problems with mental health (especially depression and anxiety), and more need for psychiatric care and medication (<xref ref-type="bibr" rid="B13">Rouhe et al., 2011</xref>). Also, a systematic review reported on the association between FOC and obstetric complications, such as prolonged labour, use of epidural, instrumental birth, and posttraumatic stress symptoms after childbirth (<xref ref-type="bibr" rid="B03">Dencker et al., 2019</xref>). About 15% of primiparous women and 7% of multiparous women have high FOC (<xref ref-type="bibr" rid="B07">Joki-Begi et al., 2013</xref>; <xref ref-type="bibr" rid="B08">Kuljanac et al., 2023</xref>).</p>
        <p>Elevated FOC is associated with some personality dispositions, such as trait anxiety, anxious sensitivity (<xref ref-type="bibr" rid="B07">Joki-Begi et al., 2013</xref>), neuroticism (<xref ref-type="bibr" rid="B05">Handelzalts et al., 2015</xref>), and perfectionism (<xref ref-type="bibr" rid="B08">Kuljanac et al., 2023</xref>). Recent literature was focused on intolerance to uncertainty (IU), an important transdiagnostic factor for anxiety and depression disorders (<xref ref-type="bibr" rid="B09">Mahoney &amp; McEvoy, 2012</xref>), and “key construct related to worry” (<xref ref-type="bibr" rid="B01">Birrell et al., 2011</xref>, pp. 1206). The definition of the IU has changed throughout the years. The newest conceptualisation of IU emphasises that IU could present the latent fear of the unknown or tendency to perceive the occurrence of a negative event as threatening regardless of the possibility of its occurrence (<xref ref-type="bibr" rid="B02">Carleton, 2012</xref>). <xref ref-type="bibr" rid="B01">Birrell et al. (2011)</xref>, in a review of the latent structure of the construct, suggested that two factors could be identified: the desire for predictability and an active engagement in seeking certainty, and the paralysis of cognition and action in the face of uncertainty.</p>
        <p>Individuals high in IU tend to experience increased anxiety in uncertain situations, and childbirth is one of them. Although childbirth is a physiological process, it can be unpredictable and uncontrollable (<xref ref-type="bibr" rid="B14">Wijma et al., 1998</xref>). The IU was shown as a significant predictor of FOC in pregnant women (<xref ref-type="bibr" rid="B12">Rondung et al., 2018</xref>), but the evidence is still scarce, and findings about that relation in women are still inconsistent. For example, IU was predictor of fear of childbirth in pregnant women in Sweden (<xref ref-type="bibr" rid="B12">Rondung et al., 2018</xref>), but not in primiparous and multiparous pregnant women in Croatia (<xref ref-type="bibr" rid="B08">Kuljanac et al., 2023</xref>). Also, little is known about mediators or the relation between the FOC and IU.</p>
        <p>Individuals with high IU tend to seek predictability (<xref ref-type="bibr" rid="B01">Birrell et al., 2011</xref>), so they could actively engage in various actions that can increase the predictability of a situation and decrease uncertainty. It is possible that preparedness for childbirth could decrease FOC in women with high IU. We hypothesised that the association between IU and FOC could be mediated through perceived preparedness for childbirth in pregnant women. Therefore, this study aimed to examine the mediating role of perceived preparedness for childbirth between IU and FOC in primiparous and multiparous pregnant women.</p>
      </sec>   <sec sec-type="methods">
            <title>Method</title>
            <sec>
                <title>Participants</title>
                <p>In this cross-sectional study, 292 women participated, of which 168 were primiparous and 124 were multiparous pregnant women. The majority of the participants were highly educated (66.1% of nulliparous, 64.5% of multiparous), lived in an urban place (83.3% of nulliparous, 86.2% of multiparous), and perceived their socioeconomic status as average (61.3% of nulliparous, 57.8% of multiparous). Also, almost all pregnant women were married or cohabitating (94.1 % of nulliparous and 100% of multiparous) and employed (98.2% of nulliparous and 97.5% of multiparous). The sample was described previously in detail (<xref ref-type="bibr" rid="B08">Kuljanac et al., 2023</xref>).</p>
            </sec>
            <sec>
                <title>Instruments</title>
                <p>FOC was measured with Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ; <xref ref-type="bibr" rid="B14">Wijma et al., 1998</xref>) using version A, which measures expectations before childbirth. Two items regarding thoughts about death and harming the baby were excluded; therefore, the scale consisted of 31 items. Results could range from 0 to 155, so a higher result indicates higher FOC, but a clinically significant score was equal to 85 or above (<xref ref-type="bibr" rid="B11">Ryding et al., 1998</xref>). In this study, Cronbach α was .92.</p>
                <p>Intolerance of uncertainty was measured with the 11-item Intolerance of Uncertainty Scale (IUS; <xref ref-type="bibr" rid="B04">Freeston et al., 1994</xref>). Although the scale consists of two subscales, Prospective and Inhibitory Anxiety, we obtained a one-factor solution and used only the total score. Higher scores indicate higher intolerance of uncertainty, and the theoretical range is from 1 to 55. In this study, Cronbach α was .92.</p>
                <p>Perceived preparedness for childbirth was measured with only one item in all three groups: “How prepared do you feel for childbirth?”, and answers were on a 5-point scale from 1 (<italic>not at all</italic>) to 5 (<italic>completely</italic>), so a higher score indicated higher preparedness.</p>
            </sec>
            <sec>
                <title>Procedure</title>
                <p>Pregnant women filled out questionnaires at the prenatal clinic while waiting for regular prenatal checkups. The study was cross-sectional and approved by the Ethical Committee of the Catholic University of Croatia and by the Ethical Committee of the University Hospital Center Sisters of Mercy (see details in <xref ref-type="bibr" rid="B08">Kuljanac et al., 2023</xref>).</p>
            </sec>
            <sec>
                <title>Statistical Analyses</title>
                <p>The Pearson coefficient was used to examine correlations between variables in the software SPSS 21.0 for Windows. Mediation analyses were conducted in Process Macro 3.2.01 for SPSS (<xref ref-type="bibr" rid="B06">Hayes, 2013</xref>) using model 4. In the mediation analysis, the predictor was IU, the criterion variable was FOC, and preparedness for childbirth was a mediator. The bootstrap method (5,000 samples) was used, and the confidence interval (CI) was 95%. The effect was significant if the confidence interval did not contain zero. Non-standardised estimates were calculated and presented.</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <p>The descriptive data were examined for all variables in primiparous and multiparous women (<xref ref-type="table" rid="t01">Table 1</xref>). Of the sample, 15.5% of primiparous and 7.3% of multiparous women had high FOC (score 85 and above). Both groups of pregnant women had moderate levels of IU and low to moderate levels of FOC, and mean levels did not significantly differ between primimarous and multiparous women. However, multiparous women reported significantly better preparedness for childbirth than primiparous women (<xref ref-type="table" rid="t01">Table 1</xref>).</p>
            <p>
            <table-wrap id="t01">
                <label>Table 1</label>
                <caption>
                    <title>Descriptive Data for Intolerance of Uncertainty, Perceived Preparedness for Childbirth, and Fear of Childbirth</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-35-1-0035-gt01.jpg"/>
                <table-wrap-foot>
                    <fn>
                        <p><italic>Note</italic>. IU = intolerance of uncertainty; PPC = perceived preparedness for childbirth; FOC = fear of childbirth.</p>
                        <p>*<italic>p</italic> = .046</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </p>
            <p>The association between IU, FOC, and perceived preparedness for childbirth were examined in pregnant primiparous and pregnant multiparous women (<xref ref-type="table" rid="t02">Table 2</xref>). In primiparous women, higher IU was correlated with higher FOC, while lower perceived preparedness for childbirth was correlated with higher IU and FOC. In multiparous women, IU was not associated with FOC and perceived preparedness for childbirth, therefore, mediation analyses could not be performed in this subsample.</p>
            <p>
            <table-wrap id="t02">
                <label>Table 2</label>
                <caption>
                    <title>Correlation of Intolerance of Uncertainty, Perceived Preparedness for Childbirth, and Fear of Childbirth in Primiparous (<italic>n</italic> = 168) (above diagonal) and Multiparous Women (<italic>n</italic> = 124) (below diagonal)</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-35-1-0035-gt02.jpg"/>
                <table-wrap-foot>
                    <fn>
                        <p><italic>Note</italic>. IU = intolerance of uncertainty; PPC = perceived preparedness for childbirth; FOC = fear of childbirth.</p>
                        <p>**<italic>p</italic> &lt; .01.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </p>
            <p>A mediation analysis was conducted on primiparous women, where IU was the predictor, perceived preparedness for childbirth the mediator, and FOC the outcome (<xref ref-type="fig" rid="f01">Figure 1</xref>). In primiparous pregnant women, IU predicted fear of childbirth only indirectly (<italic>B</italic> = 0.31, <italic>SE</italic> = 0.12, CI [.10, .58]) through perceived preparedness for childbirth and not directly (<italic>B</italic> = 0.30, <italic>SE</italic> = 0.17, CI [-.04, .64]). Therefore, perceived preparedness for childbirth was a full mediator between IU and FOC (<xref ref-type="fig" rid="f01">Figure 1</xref>). The model explained 29.4% of the variance of FOC.</p>
            <p>
            <fig id="f01">
                <label>Figure 1</label>
                <caption>
                    <title>Perceived Preparedness for Childbirth as Mediator between Intolerance of Uncertainty and Fear of Childbirth in Primiparous Women (<italic>n</italic> =168).</title>
                </caption>
                <graphic xlink:href="1130-5274-clinsa-35-1-0035-gf01.jpg"/>
            </fig>
        </p>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>This study aimed to examine whether preparedness for childbirth was a mediator between IU and FOC in primiparous and multiparous women. Results showed that IU predicted FOC only indirectly through lower perceived preparedness for childbirth in primiparous pregnant women. On the other hand, in multiparous women, IU was neither associated with FOC nor with preparedness for childbirth, so the mediation analysis could not be conducted.</p>
            <p>In pregnant primiparous women, i.e., women with no previous experience of childbirth, preparedness for childbirth was a significant mediator between IU and FOC. Women with high intolerance of uncertainty also perceived that they were unprepared for delivery which predicted elevated FOC. These results align with the theoretical framework of IU, claiming that preparedness and seeking information could decrease worry and anxiety in individuals with high IU (<xref ref-type="bibr" rid="B01">Birrell et al., 2011</xref>). Contrary to primiparous women, IU was not correlated with FOC in multiparous women. The latter is in line with previous findings implying that previous experiences, and not personality dispositions, were more relevant predictors for high FOC (<xref ref-type="bibr" rid="B07">Jokić-Begić et al., 2014</xref>; <xref ref-type="bibr" rid="B08">Kuljanac et al., 2023</xref>).</p>
            <p>These findings have some practical implications. Preventive programs for FOC should aim at first-time pregnant and multiparous women. As preparedness is important in all groups of women, preventive programs and courses should especially emphasise FOC and empower women to cope with it. Giving adequate information regarding childbirth and addressing and diminishing fears and concerns is crucial. On the other hand, interventions regarding reducing FOC in multiparous women should focus on their previous childbirth experiences, especially if it was perceived as traumatic. The risk of not providing preventive and interventive programs could be very high – it could impact women’s well-being or their decision not to have (more) children.</p>
            <p>Limitations of this study should be considered. First, this study was cross-sectional, and a longitudinal design should be applied in the future to test full mediation analysis. Second, we have used only one question to assess the preparedness for childbirth, so it is recommended to use a questionnaire in future studies, and a recently developed Childbirth Readiness Scale (<xref ref-type="bibr" rid="B10">Mengmei et al., 2022</xref>) sounds a promising tool for such a purpose. Third, the sample was convenient and consisted of highly educated participants with average socioeconomic status living in urban areas with their partners (especially pregnant women). Therefore, the results could be somewhat different if participants were women who did not have access to information and courses regarding childbirth (e.g., minority groups), although most of the prenatal classes in Croatia are free. Finally, other underlying mechanisms between intolerance of uncertainty and fear of childbirth should be examined to elucidate the complexity of these relations. Also, longitudinal design studies should be conducted in order to follow non-pregnant women throughout their pregnancy. Additionally, it would be beneficial to examine how preparedness and some preventive interventions could diminish FOC during the first pregnancy. Further research regarding effective treatment for FOC tailored to women’s personality characteristics and previous experience and expectations is needed for all groups of women.</p>
        </sec>
    </body>
    <back>
        <fn-group>
            <fn fn-type="other">
                <p>Cite this article as: Brekalo, M., Kuljanac, A., &amp; Nakić Radoš, S. (2024). Intolerance of uncertainty and fear of childbirth: Role of perceived preparedness for childbirth. <italic>Clínica y Salud, 35</italic>(1), 35-38. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5093/clysa2024a10">https://doi.org/10.5093/clysa2024a10</ext-link></p>
            </fn>
        </fn-group>
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