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	<front>
		<journal-meta>
			<journal-id journal-id-type="publisher-id">eg</journal-id>
			<journal-title-group>
				<journal-title>Enfermería Global</journal-title>
				<abbrev-journal-title abbrev-type="publisher">Enferm. glob.</abbrev-journal-title>
			</journal-title-group>
			<issn pub-type="epub">1695-6141</issn>
			<publisher>
				<publisher-name>Universidad de Murcia</publisher-name>
			</publisher>
		</journal-meta>
		<article-meta>
			<article-id pub-id-type="doi">10.6018/eglobal.18.1.322641</article-id>
			<article-id pub-id-type="publisher-id">00002</article-id>
			<article-categories>
				<subj-group subj-group-type="heading">
					<subject>Originales</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Asociación entre olor y aislamiento social en pacientes con heridas tumorales malignas: estudio piloto</article-title>
				<trans-title-group xml:lang="en">
					<trans-title>Association between odor and social isolation in patients with malignant tumor wounds: pilot study</trans-title>
				</trans-title-group>
				<trans-title-group xml:lang="pt">
					<trans-title>Associação entre odor e isolamento social em pacientes com feridas tumorais malignas: estudo piloto</trans-title>
				</trans-title-group>
			</title-group>
			<contrib-group>
				<contrib contrib-type="author">
					<name>
						<surname>Alves dos Santos</surname>
						<given-names>Willian</given-names>
					</name>
					<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>dos Santos Claro Fuly</surname>
						<given-names>Patricia</given-names>
					</name>
					<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Dutra Souto</surname>
						<given-names>Marise</given-names>
					</name>
					<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Caldeira dos Santos</surname>
						<given-names>Mauro Leonardo Salvador</given-names>
					</name>
					<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>de Lima Beretta</surname>
						<given-names>Luiza</given-names>
					</name>
					<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
				</contrib>
			</contrib-group>
			<aff id="aff1">
				<label>1</label>
				<institution content-type="original"> Enfermero. Maestría en Ciencias del Cuidado en Salud por la EEAAC/UFF. Icaraí, Niterói, Rio de Janeiro, Brasil. willian.allves@hotmail.com</institution>
				<institution content-type="orgname">EEAAC/UFF</institution>
				<addr-line>
					<named-content content-type="state">Icaraí, Niterói</named-content>
					<named-content content-type="city">Rio de Janeiro</named-content>
				</addr-line>
				<country country="BR">Brasil</country>
				<email>willian.allves@hotmail.com</email>
			</aff>
			<aff id="aff2">
				<label>2</label>
				<institution content-type="original"> Enfermera. Doctora en Enfermería. Profesora Adjunta del Departamento de Enfermería Médico - Quirúrgica de EEAAC/UFF. Brasil. </institution>
				<institution content-type="orgname">EEAAC/UFF</institution>
				<country country="BR">Brasil</country>
			</aff>
			<aff id="aff3">
				<label>3</label>
				<institution content-type="original"> Enfermera. Doctora en Enfermería. Coordinadora de Proyecto de Desarrollo del Instituto Nacional de Cáncer (INCA).. Brasil. </institution>
				<institution content-type="orgname">Instituto Nacional de Cáncer (INCA)</institution>
				<country country="BR">Brasil</country>
			</aff>
			<aff id="aff4">
				<label>4</label>
				<institution content-type="original"> Enfermera. Discente de la Maestría Académica en Ciencias del Cuidado en Salud de la EEAAC/UFF. Brasil </institution>
				<institution content-type="orgname">EEAAC/UFF</institution>
				<country country="BR">Brasil</country>
			</aff>
			<pub-date pub-type="epub">
				<month>01</month>
				<year>2019</year>
			</pub-date>
			<volume>18</volume>
			<issue>53</issue>
			<fpage>19</fpage>
			<lpage>65</lpage>
			<history>
				<date date-type="received">
					<day>24</day>
					<month>02</month>
					<year>2018</year>
				</date>
				<date date-type="accepted">
					<day>02</day>
					<month>06</month>
					<year>2018</year>
				</date>
			</history>
			<permissions>
				<license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc-nd/3.0/" xml:lang="es">
					<license-p>Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons</license-p>
				</license>
			</permissions>
			<abstract>
				<title>RESUMEN:</title>
				<sec>
					<title>Objetivo</title>
					<p> Analizar las asociaciones entre olores y aislamiento social en pacientes con heridas tumorales malignas.</p>
				</sec>
				<sec>
					<title>Material y método</title>
					<p> Estudio piloto con corte transversal realizado con nueve pacientes con heridas tumorales malignas atendidas en un hospital universitario en el período de 2014 a 2016. Se recogieron datos por medio de aplicación de escala likert de cinco puntos para evaluación del aislamiento social relacionado con el olor de las heridas tumorales malignas durante las consultas de enfermería. Se analizaron los datos por estrategia estadística inferencial con cálculo de coeficiente de Spearman al nivel de significancia del 5% (α = 0,05).</p>
				</sec>
				<sec>
					<title>Resultados</title>
					<p> Se constató correlación con significancia estadística entre el olor y las dimensiones psicosociales: constreñimiento y limitación en frecuentar locales públicos.</p>
				</sec>
				<sec>
					<title>Conclusión</title>
					<p> El olor es el principal síntoma que genera constreñimiento y limita la convivencia social, favoreciendo el aislamiento social y la degradación de la calidad de vida de los pacientes oncológicos.</p>
				</sec>
			</abstract>
			<trans-abstract xml:lang="en">
				<title>ABSTRACT:</title>
				<sec>
					<title>Objective</title>
					<p> To analysis associations between odor and social isolation in patients with malignant tumor wounds.</p>
				</sec>
				<sec>
					<title>Material and method</title>
					<p> A cross-sectional pilot study performed with nine patients with malignant tumor wounds treated at a university hospital from 2014 to 2016. Data were collected using a five-point likert scale for the evaluation of social isolation related to odor of malignant tumor wounds during nursing consultations. Data were analyzed by inferential statistical strategy with Spearman's coefficient at the significance level of 5% (α = 0.05).</p>
				</sec>
				<sec>
					<title>Results</title>
					<p> Correlation was found with statistical significance between odor and psychosocial dimensions: constraint and limitation in attending public places.</p>
				</sec>
				<sec>
					<title>Conclusion</title>
					<p> odor is the main symptom that causes embarrassment and limits social coexistence, favoring social isolation and degradation of the quality of life of cancer patients.</p>
				</sec>
			</trans-abstract>
			<trans-abstract xml:lang="pt">
				<title>RESUMO:</title>
				<sec>
					<title>Objetivo:</title>
					<p> Identificar as associações entre odor e isolamento social em pacientes com feridas tumorais malignas. </p>
				</sec>
				<sec>
					<title>Material e método:</title>
					<p> Estudo piloto com corte transversal realizado com nove pacientes com feridas tumorais malignas atendidos em um hospital universitário no período de 2014 a 2016. Coletaram-se dados por meio de aplicação de escala <italic>likert</italic> de cinco pontos para avaliação do isolamento social relacionado ao odor de feridas tumorais malignas, durante as consultas de enfermagem. Analisaram-se os dados por estratégia estatística inferencial com cálculo de coeficiente de <italic>Spearman</italic> ao nível de significância de 5% (α = 0,05). </p>
				</sec>
				<sec>
					<title>Resultados:</title>
					<p> Constatou-se correlação com significância estatística entre o odor e as dimensões psicossociais: constrangimento e limitação em frequentar locais públicos. </p>
				</sec>
				<sec>
					<title>Conclusão:</title>
					<p> O odor é o principal sintoma que gera constrangimento e limita a convivência social, favorecendo o isolamento social e a degradação da qualidade de vida dos pacientes oncológicos.</p>
				</sec>
	       </trans-abstract>
			<kwd-group xml:lang="es">
				<title>Palabras clave</title>
				<kwd>Enfermería oncológica</kwd>
				<kwd>Heridas y traumatismos</kwd>
				<kwd>Aislamiento social</kwd>
				<kwd>Cuidados paliativos</kwd>
				<kwd>Enfermería</kwd>
			</kwd-group>
			<kwd-group xml:lang="en">
				<title>Key words:</title>
				<kwd>Oncology nursing</kwd>
				<kwd>Wounds and injuries</kwd>
				<kwd>Social isolation</kwd>
				<kwd>Palliative care</kwd>
				<kwd>Nursing</kwd>
			</kwd-group>
			<kwd-group xml:lang="pt">
				<title>Palavras-chave:</title>
				<kwd>Enfermagem oncológica</kwd>
				<kwd>Ferimentos e lesões</kwd>
				<kwd>Isolamento social</kwd>
				<kwd>Cuidados paliativos</kwd>
				<kwd>Enfermagem</kwd>
			</kwd-group>
			<funding-group>
				<award-group award-type="contract">
					<funding-source>Consejo Nacional de Desarrollo Científico y Tecnológico (CNPQ)</funding-source>
					<award-id>Edital PIBIC/ CNPQ/ UFF 2015-2016</award-id>
				</award-group>
			</funding-group>
			<counts>
				<fig-count count="0"/>
				<table-count count="4"/>
				<equation-count count="0"/>
				<ref-count count="30"/>
				<page-count count="47"/>
			</counts>
		</article-meta>
	</front>
	<body>
		<sec sec-type="intro">
			<title>INTRODUCCIÓN</title>
			<p>Las heridas tumorales malignas (HTM) afectan aproximadamente del 5% al 10% de los pacientes con neoplasias, estando presentes en la mayoría de los casos en los últimos seis meses de vida<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B2"><sup>2</sup></xref>. Sin embargo, en un estudio más reciente se observa la incidencia de esta lesión en el 14,5% de los individuos oncológicos<xref ref-type="bibr" rid="B3"><sup>3</sup></xref>, siendo comúnmente vinculados al tumor primario o metastásico<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref>. El tratamiento se compone sobre todo de la cirugía paliativa con el fin de minimizar los signos y síntomas para promover una mejor calidad de vida<xref ref-type="bibr" rid="B1"><sup>1</sup></xref>.</p>
			<p>Estas lesiones se originan por la infiltración de las células malignas del tumor en las composiciones de la piel. Hay una quiebra de la integridad del tegumento y cuando acontece la proliferación celular desordenada del proceso de oncogénesis, culmina en la formación de la herida, acometiendo progresivamente la piel, desfigurando el cuerpo, tornándose dolorosas y con olor fétido<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B6"><sup>6</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B7"><sup>7</sup></xref>.</p>
			<p>El olor es considerado síntoma de presencia constante en el cotidiano de los pacientes con HTM, en que un estudio observó que el 10,4% de los casos de olor están asociados a esas lesiones<xref ref-type="bibr" rid="B3"><sup>3</sup></xref>. Con el crecimiento desordenado y anormal de la lesión, se tiene la formación de agregados de masa tumoral necrótica, donde ocurre la contaminación por microorganismos aeróbicos (<italic>Pseudomonas aeruginosa y Staphylococcus aureus</italic>) y anaeróbicos (bacteroides), obteniendo como producto de su metabolismo ácidos grasos volátiles (ácido acético, cáprico), gases putrescina y cadaverina, que son responsables del olor fétido<xref ref-type="bibr" rid="B8"><sup>8</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref>.</p>
			<p>Esta situación se caracteriza por ser un obstáculo importante en el proceso de atención y comprobar mal olor para el paciente y la gente que conoce, añade ansiedad en el avance de la enfermedad, restricción social y familiar<xref ref-type="bibr" rid="B1"><sup>1</sup></xref>. Fisiológicamente, la percepción del mal olor se procesa en los bulbos olfativos localizados en el cerebro, en los sistemas neurales límbicos e hipotalámicos que son responsables del comportamiento motivacional y emocional. Además, genera a los pacientes ahogos involuntarios desencadenados por el reflejo del vómito, disminuyendo la sensación de sabor y apetito, afectando al estado nutricional. Por lo tanto, los efectos del olor son devastadores sobre la vida del paciente, llevando al estrés nutricional, psicológico y aislamiento social<xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref>.</p>
			<p>El aislamiento social se define como un estado en el que el individuo carece de sentido de pertenencia social, con desajuste de lazos sociales, conexiones institucionales o participación de la comunidad, siendo potencial predictor de riesgo de mortalidad<xref ref-type="bibr" rid="B11"><sup>11</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B12"><sup>12</sup></xref>. De esta forma, es importante la atención multiprofesional, pues la acción holística puede acarrear mejoría de la autoestima y de la calidad de vida del paciente, una vez que el mal olor está ligado a ese aislamiento<xref ref-type="bibr" rid="B13"><sup>13</sup></xref>.</p>
			<p>Para el equipo de Enfermería, hay una gran dificultad en el control de los síntomas relacionados con la herida, destacando el olor que, la mayoría de las veces es relatado como imprevisible e incontrolable. Este síntoma se caracteriza como gran problema al paciente, imponiendo una situación de aislamiento social, deteriorando aún más su condición de salud<xref ref-type="bibr" rid="B5"><sup>5</sup></xref>. Por lo tanto, es necesario el desarrollo de investigaciones para la construcción y validación de protocolos, con el objetivo de controlar los síntomas resultantes de ese tipo de lesión, mejorando de esa forma el cuidado y disminuyendo el estrés vivido por los pacientes, familiares y profesionales de salud<xref ref-type="bibr" rid="B9"><sup>9</sup></xref>.</p>
			<p>En vista de la influencia del olor sobre los aspectos psicosociales del paciente con tales lesiones presentes en la literatura científica y en la práctica del cuidado, el estudio tiene por objetivo identificar las posibles asociaciones entre el olor y factores que resultan en aislamiento social en pacientes con HTM.</p>
		</sec>
		<sec sec-type="methods">
			<title>METODOLOGÍA</title>
			<p>La investigación es un subproyecto del Proyecto Casadinho UFF-USP, aprobado en llamada pública MCT/CNPq/MEC/CAPES - Acción Transversal nº 06/2011 - Casadinho/Procad: Innovación en Enfermería en el tratamiento de lesiones tisulares - sistematización, inclusión tecnológica y funcionalidad.</p>
			<p>Se trata de un estudio piloto transversal con enfoque cuantitativo, realizado en el Ambulatorio de Cuidados Paliativos de un Hospital Universitario y ejecutado en el período de septiembre de 2014 a enero de 2016.</p>
			<p>Este ambulatorio está habilitado como Unidad de Alta Complejidad en Oncología (UNACON) desde 2009, estando habilitado para proporcionar asistencia especializada e integral para el diagnóstico definitivo, tratamiento y acompañamiento de cáncer<xref ref-type="bibr" rid="B14"><sup>14</sup></xref>.</p>
			<p>El estudio es una extensión de la investigación “Análisis de asociación de heridas tumorales, sitio primario y variables demográficas: implicaciones para la sistematización de la asistencia de enfermería”, con la aprobación del Comité de ética e investigación nº 183.757 el 11/01/2013.</p>
			<p>Población o muestra: criterios de inclusión y exclusión</p>
			<p>La muestra de conveniencia fue compuesta por todos los pacientes con HTM atendidos en el local durante el período del estudio, que acataron los siguientes criterios de elegibilidad: ser mayor de 18 años; tener diagnóstico de cáncer (cualquier topografía) en etapa avanzada registrada en archivo; la presencia de HTM clasificada en estadio 1N o superiores (una vez que sólo superior a esa etapa la lesión presenta síntomas), de cualquier topografía, manifestando autorización en participar de la investigación mediante la firma del Término de Consentimiento Libre y Esclarecido. Fue criterio de exclusión: la presencia de lesiones oriundas de tratamiento radioterápico (radiodermitis). Se destaca que se consideró como criterio de discontinuidad la imposibilidad de participar en la consulta de enfermería para el intercambio de curativo y los casos de defunción en el período del estudio antes de la realización de la consulta de enfermería.</p>
			<p>Protocolo del estudio</p>
			<p>Para la operación de la recolección de los datos fue instituido el momento de la consulta de enfermería, con consecuente cambio de curativos, para análisis y llenado del formulario de recolección de datos, conteniendo las siguientes variables para colecta en registro: sociodemográficas (sexo, edad, etnia, escolaridad de acuerdo con la normativa vigente en el país de origen, en el caso de que se trate de un accidente de tránsito, tratamiento, productos utilizados y clasificación del olor).</p>
			<p>Se aplicó la Escala de Olor para evaluación y clasificación de olor y el llenado de la escala del tipo Likert, que es un instrumento compuesto por 15 ítems, subdivido en 3 dimensiones (herida, exudado y olor) con respuestas organizadas en escala de cinco puntos (1 = nada, 2 = poco, 3 = razonable, 4 = mucho, 5 = totalmente) sobre los aspectos psicosociales del paciente involucrando las heridas y los síntomas con puntuación máxima del instrumento de 75 puntos. En el estudio, se tuvo en cuenta sólo la dimensión olor.</p>
			<p>Se midió, para esa dimensión, la confiabilidad interna por el Coeficiente de Alfa de Cronbach, considerando un valor por encima de (0,7) como satisfactorio.</p>
			<p>Escala Likert de evaluación</p>
			<p>La construcción de la escala se dio en cuatro pasos. En la primera fase, se realizó una revisión integradora de la literatura, a fin de verificar cuáles son las lagunas del conocimiento existentes en el contexto de las heridas neoplásicas. Después de la tabulación de información, se identificó que los síntomas son los principales factores que degradan la calidad de vida y psicosocial del paciente con lesión tumoral, sobre todo el olor y exudado, con el 90,69% y el 100% de los artículos, así como el aislamiento social que se describe en el 67,44% de los artículos, generalmente asociados a la afectación de heridas fétidas y exudativas.</p>
			<p>La segunda etapa constituyó la realización de una investigación sistemática de la literatura en las bases de los datos Lilacs, Medline y Cochrane con los descriptores en ciencias de la salud (DeC): olores; aislamiento social; exudados y transudados y Medical Subject Headings Mesh Terms: exudates y transudates; social isolation, así como con las palabras clave y keywords: heridas neoplásicas, heridas tumorales, malodorous; psychological factors; psychosocial aspects; malignant wound; fungating wound; malignant fungating wound con selección de 37 evidencias científicas lo que posibilitó encontrar el constructo teórico sobre el aislamiento social en pacientes con olor y exudado en heridas neoplásicas. Se realizó la lectura de todos los artículos a fin de conocer las evidencias sobre el fenómeno efectuando el mapeo de los principales factores psicosociales comprometidos por el olor y exudado en pacientes con heridas neoplásicas. Cada referencia científica fue tabulada y agrupada de acuerdo con los aspectos psicosociales evidenciados. En consecuencia, fue posible establecer tres dimensiones en la escala, contando para cada uno con cinco ítems abordando áreas psicosociales distintas: constreñimiento, limitación en salir de casa, limitación de relación con la red de amigos y familiares, limitación en frecuentar locales públicos.</p>
			<p>Los elementos del instrumento fueron elaborados en forma de preguntas cerradas con lenguaje de fácil acceso, a fin de proporcionar una adecuada interpretación del instrumento y la obtención de datos. Con eso, la escala fue dividida en tres dimensiones: herida, olor y exudado, así como los cinco factores psicosociales en común, los cuales fueron determinados: a) ¿Hasta qué punto para usted, el mal olor exhalado a través de la herida es vergonzoso?; b) ¿Hasta qué punto el mal olor exhalado a través de la herida interfiere negativamente en salir de casa?; c) ¿Hasta qué punto el mal olor exhalado a través de la herida interfiere negativamente en su relación con su familia?; d) ¿Hasta qué punto el mal olor exhalado a través de la herida interfiere negativamente en su relación con sus amigos?; e) ¿Hasta qué punto el mal olor exhalado a través de la herida hace que usted evite frecuentar lugares públicos ?, siendo así los cinco ítems de cada dimensión de la escala.</p>
			<p>Las escalas del tipo Likert o escalas sumadas se caracterizan como psicométricas ampliamente utilizadas en investigaciones cuantitativas que proporcionan al entrevistado la indicación cuantitativa del grado de concordancia o desacuerdo frente a las variables que se están evaluando. Se asignan valores numéricos para referirse a la fuerza y la dirección del marcado.</p>
			<p>Análisis de los resultados y estadística</p>
			<p>Los datos fueron tabulados en el programa Excel - Windows 2010, con posterior empleo del análisis estadístico realizado con el auxilio del <italic>Statistical Package for the Social Sciences</italic> (SPSS). Se aplicó el test de normalidad <italic>Shappiro - wilk</italic>, para la verificación si la muestra es paramétrica (p valor &gt; 0,05) o no paramétrica (p valor ≤ 0,05). Para la variable paramétrica, los datos fueron presentados con medidas descriptivas simples: media y desviación estándar ( x ±D.P), y para las variables no paramétricas, los datos fueron presentados por la mediana e intervalo intercuartil ( x ± Q<sub>3</sub>-Q<sub>1</sub>). Se efectuó un análisis de correlación de <italic>Spearman</italic> y tablas de frecuencia cruzadas entre el grado de olor con las cinco cuestiones de la escala <italic>likert</italic> de la dimensión olor para verificar la existencia de asociación entre el olor y factores que favorecen el aislamiento social en pacientes con HTM. El test de correlación fue realizado con 95% de confianza y 0,05 de significancia.</p>
		</sec>
		<sec sec-type="results">
			<title>RESULTADOS</title>
			<p>La muestra fue compuesta por 77,78% (7) del sexo femenino y 22,22% (2) del sexo masculino con edad entre 29 y 74 años (promedio = 59 años) por pacientes atendidos por la enfermería en la primera consulta o evaluación recurrente. Gran parte de los participantes nacieron en Río de Janeiro, viviendo en el estado de origen. Con respecto a la escolaridad, se observa que la mayoría de los participantes posee enseñanza básica completa o incompleta 66,67% (6). El estado laboral jubilado/pensionista comportó 77.78% (7) de la muestra, siendo caracterizado por edad, tiempo de servicio o enfermedad. El cuantitativo de hasta un salario mínimo fue responsable por el ingreso mensual del 66,67% (6) de los pacientes.</p>
			<p>
				<table-wrap id="t1">
					<label>Tabla 1</label>
					<caption>
						<title>Distribución de los datos de la muestra según sus características sociodemográficas. Rio de Janeiro, Brasil, 2016.</title>
					</caption>
					<graphic xlink:href="1695-6141-eg-18-53-19-gt1.png"/>
				</table-wrap>
			</p>
			<p>En lo que se refiere a las variables clínicas, se observa que el 33,33% no posee ningún tipo de comorbilidad, siendo que el 22,22% (2) tiene hipertensión arterial sistémica y 33,33% (3) tiene diabetes del tipo 2. El diagnóstico médico más prevalente fue el de carcinoma ductal infiltrante, responsable por 44,44% (4) de los casos, seguido de carcinoma epidermoide con 22,22% (2). El sitio primario de surgimiento patológico fue principalmente en mama 55,56% (5) y canal anal 22,22% (2).</p>
			<p>
				<table-wrap id="t2">
					<label>Tabla 2</label>
					<caption>
						<title>Distribución de los datos de la muestra según sus características clínicas. Rio de Janeiro, Brasil, 2016.</title>
					</caption>
					<table>
						<colgroup>
							<col/>
							<col/>
							<col/>
						</colgroup>
						<thead>
							<tr>
								<th align="left">Variables</th>
								<th align="center">N</th>
								<th align="center">%</th>
							</tr>
						</thead>
						<tbody>
							<tr>
								<td align="left">Diabetes</td>
								<td align="center">3</td>
								<td align="center">33,33</td>
							</tr>
							<tr>
								<td align="left">Hipertensión arterial sistémica </td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Cirrosis hepática</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">No hay </td>
								<td align="center">3</td>
								<td align="center">33,33</td>
							</tr>
							<tr>
								<td align="left">Diagnóstico médico</td>
								<td align="center"> </td>
								<td align="center"> </td>
							</tr>
							<tr>
								<td align="left">Carcinoma ductal infiltrante</td>
								<td align="center">4</td>
								<td align="center">44,44</td>
							</tr>
							<tr>
								<td align="left">Adenocarcinoma de endometrio</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Adenocarcinoma anal</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Carcinoma metaplásico</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Carcinoma epidermoide</td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Carcinoma escamoso</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Sitio primario tumoral</td>
								<td align="center"> </td>
								<td align="center"> </td>
							</tr>
							<tr>
								<td align="left">Mama </td>
								<td align="center">5</td>
								<td align="center">55,56</td>
							</tr>
							<tr>
								<td align="left">Canal anal </td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Útero </td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Lengua </td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
						</tbody>
					</table>
				</table-wrap>
			</p>
			<p>En los datos clínicos de la lesión, la mama derecha fue el lugar que comportó mayor índice de esas lesiones, siendo responsables por 33,33% (3) del fenómeno, en mama izquierda se observó el 22,22% (2) y la región anal 22,22% (2) de los casos.</p>
			<p>En cuanto al estado de la lesión, fue posible observar que el 33,33% (3) se encuadran en la categoría 3 y 55,56% (5) de las lesiones estaban en estado 2. Además, las circunstancias del surgimiento de la HTM también están siendo analizadas, cerca de 33,33% (3) de las lesiones surgieron después de la cirugía de resección del tumor, siendo de esas 60% en la forma de plastrón. Aproximadamente 22,22% (2) aparecieron después de la realización de biopsia y solamente 22,22% (2) espontáneamente.</p>
			<p>
				<table-wrap id="t3">
					<label>Tabla 3</label>
					<caption>
						<title>Distribución de los datos de la muestra según sus características clínicas de la lesión. Rio de Janeiro, Brasil, 2016.</title>
					</caption>
					<table>
						<colgroup>
							<col/>
							<col/>
							<col/>
						</colgroup>
						<thead>
							<tr>
								<th align="left">Variables</th>
								<th align="center">N</th>
								<th align="center">%</th>
							</tr>
							<tr>
								<th align="left">Lugar de la lesión</th>
								<th align="center"> </th>
								<th align="center"> </th>
							</tr>
						</thead>
						<tbody>
							<tr>
								<td align="left">Mama izquierda</td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Mama derecha</td>
								<td align="center">3</td>
								<td align="center">33,33</td>
							</tr>
							<tr>
								<td align="left">Región inguinal</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Región anal</td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Región submandibular</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Tipo de lesión</td>
								<td align="center"> </td>
								<td align="center"> </td>
							</tr>
							<tr>
								<td align="left">Heridas vegetales malignas</td>
								<td align="center">4</td>
								<td align="center">44,44</td>
							</tr>
							<tr>
								<td align="left">Herida ulcerativa maligna</td>
								<td align="center">5</td>
								<td align="center">55,56</td>
							</tr>
							<tr>
								<td align="left">Heridas vegetales malignas ulceradas</td>
								<td align="center">0</td>
								<td align="center">---</td>
							</tr>
							<tr>
								<td align="left">Estado</td>
								<td align="center"> </td>
								<td align="center"> </td>
							</tr>
							<tr>
								<td align="left">1N</td>
								<td align="center">0</td>
								<td align="center">---</td>
							</tr>
							<tr>
								<td align="left">2</td>
								<td align="center">5</td>
								<td align="center">55,56</td>
							</tr>
							<tr>
								<td align="left">3</td>
								<td align="center">3</td>
								<td align="center">33,33</td>
							</tr>
							<tr>
								<td align="left">4</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">¿Cuándo surgió?</td>
								<td align="center"> </td>
								<td align="center"> </td>
							</tr>
							<tr>
								<td align="left">Después de la biopsia </td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Después de la cirugía </td>
								<td align="center">3</td>
								<td align="center">33,33</td>
							</tr>
							<tr>
								<td align="left">Espontáneamente</td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Ausente<sup>*</sup></td>
								<td align="center">2</td>
								<td align="center">22,22</td>
							</tr>
							<tr>
								<td align="left">Tratamiento</td>
								<td align="left"> </td>
								<td align="left"> </td>
							</tr>
							<tr>
								<td align="left">Neo-adyuvante</td>
								<td align="center">3</td>
								<td align="center">33,33</td>
							</tr>
							<tr>
								<td align="left">Adyuvante</td>
								<td align="center">1</td>
								<td align="center">11,11</td>
							</tr>
							<tr>
								<td align="left">Paliativo</td>
								<td align="center">5</td>
								<td align="center">55,56</td>
							</tr>
							<tr>
								<td align="left">Tiempo de lesión</td>
								<td align="center"> </td>
								<td align="center"> </td>
							</tr>
							<tr>
								<td align="left">≤ 6 meses</td>
								<td align="center">3</td>
								<td align="center">33,33</td>
							</tr>
							<tr>
								<td align="left">&gt; 6 meses</td>
								<td align="center">6</td>
								<td align="center">66,67</td>
							</tr>
							<tr>
								<td align="left">Grado de olor</td>
								<td align="center"> </td>
								<td align="center"> </td>
							</tr>
							<tr>
								<td align="left">Grado 0</td>
								<td align="center">0</td>
								<td align="center">---</td>
							</tr>
							<tr>
								<td align="left">Grado 1</td>
								<td align="center">5</td>
								<td align="center">55,56</td>
							</tr>
							<tr>
								<td align="left">Grado 2</td>
								<td align="center">4</td>
								<td align="center">44,44</td>
							</tr>
							<tr>
								<td align="left">Grado 3</td>
								<td align="center">0</td>
								<td align="center">---</td>
							</tr>
						</tbody>
					</table>
					<table-wrap-foot>
						<fn id="TFN1">
							<p>*Información no encontrada en registros.</p>
						</fn>
					</table-wrap-foot>
				</table-wrap>
			</p>
			<p>Se aplicó el test de normalidad en las variables cuantitativas: tamaño de la lesión (p:0,024), edad (p:0,156), valor total de la dimensión herida (p:0,001), valor total de la dimensión olor (p: 0,027) y valor total de la dimensión exudada (p:0,001). Se observó que sólo la variable edad tiene distribución normal. Todos los análisis que se realicen serán análisis no paramétricos. El análisis descriptivo se basó en la mediana y en la diferencia entre el tercer cuartil y el primer cuartil. El valor total de la dimensión Olor presentó mediana = 8 y diferencia de cuartil = 5.</p>
			<p>El test de correlación de Spearman evidenció los análisis entre grado de olor y sus respectivas cuestiones de la dimensión olor de la escala Likert ISPOE, en que hay correlación estadística entre el olor y la pregunta uno (aborda el constreñimiento) (p:0,0053) y la cuestión cinco (aborda la limitación en frecuentar lugares públicos) (p:0,0495).</p>
			<p>
				<table-wrap id="t4">
					<label>Tabla 4</label>
					<caption>
						<title>Tabla de frecuencia y análisis de correlación de Spearman entre el grado de olor y las preguntas de la escala Likert de la dimensión olor. Rio de Janeiro, Brasil, 2016.</title>
					</caption>
					<graphic xlink:href="1695-6141-eg-18-53-19-gt4.png"/>
					<table-wrap-foot>
						<fn id="TFN2">
							<p>*Estadísticamente significativo</p>
						</fn>
					</table-wrap-foot>
				</table-wrap>
			</p>
			<p>Se realizó la evaluación del Coeficiente del Alfa de Cronbach de la escala Likert que obtuvo valor (0,88) para la dimensión del olor, siendo satisfactoria la confiabilidad interna.</p>
		</sec>
		<sec sec-type="discussion">
			<title>DISCUSIÓN</title>
			<p>La deficiente producción científica sobre la dimensión psicosocial de los pacientes con HTM en el área de Enfermería ha demostrado la relevancia de la elaboración de investigaciones sobre el tema, destacando la importancia del profesional en integrar esa dimensión en el proceso de la sistematización del cuidado. El manejo del olor es un gran desafío para el equipo multiprofesional y portadores de lesiones tumorales, pues, además deL sentimiento de desesperanza en el equipo en alcanzar el control eficaz de los signos y síntomas, implica en el impacto en la vida del paciente, determinando la concienciación constante del avance de la enfermedad, la angustia y el aislamiento social<xref ref-type="bibr" rid="B15"><sup>15</sup></xref>.</p>
			<p>Históricamente, la incidencia de esta condición no está bien documentada, lo que dificulta la obtención de datos estadísticos oficiales. Los estudios apuntan que el 5% al 10% de los pacientes oncológicos son afectados por estas afecciones<xref ref-type="bibr" rid="B16"><sup>16</sup></xref>. Sin embargo, otras investigaciones apuntan a la prevalencia del 14,5% de esas lesiones<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B17"><sup>17</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>. Esto muestra la inexistencia de consenso sobre la incidencia de esta lesión.</p>
			<p>En lo que se refiere al grupo de edad de los pacientes, es evidente que los ancianos presentan mayor propensión a desarrollar las HTM. La literatura destaca que estas lesiones son predominantes en pacientes con edad entre 60-70 años, presentando lesiones oriundas de cáncer de mama (62%), cabeza y cuello (24%) y región genital y anal (3%)<xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>. Los datos observados en el estudio identificaron que gran parte de la muestra presentó edad superior a 60 años, siendo mayoría del sexo femenino con lesiones oriundas de cáncer de mama.</p>
			<p>La sobrevida del paciente es un factor cuestionable actualmente. Se observa que aquellos que presentan estas lesiones poseen una supervivencia de seis meses de vida después de su aparición<xref ref-type="bibr" rid="B2"><sup>2</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B19"><sup>19</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B20"><sup>20</sup></xref>. Sin embargo, en este estudio, se constataron pacientes con supervivencia arriba del período observado en la literatura científica. Las investigaciones sugieren que el aumento de la expectativa de vida de pacientes con cáncer avanzado puede estar relacionado al aumento significativo de la incidencia de HTM<xref ref-type="bibr" rid="B13"><sup>13</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>, surgiendo la necesidad de estudios que apunten a medir esas variables.</p>
			<p>En relación a la prevalencia de este síntoma en el escenario de las HTM, hay pocos estudios que evaluaron tal contexto. Un estudio internacional verificó que cerca del 10% de los pacientes con estas lesiones presentan olor<xref ref-type="bibr" rid="B3"><sup>3</sup></xref>. En un estudio brasileño realizado con 51 pacientes oncológicos portadores de HTM, el olor estuvo presente en el 72,5% de la muestra<xref ref-type="bibr" rid="B21"><sup>21</sup></xref>. A pesar de las divergencias en relación a la incidencia, este síntoma es uno de los más difíciles de obtener control, responsable de deteriorar la calidad psicosocial de los pacientes con esas lesiones<xref ref-type="bibr" rid="B22"><sup>22</sup></xref>.</p>
			<p>El principal objetivo del cuidado a las HTM es el control de los síntomas, siendo el mal olor responsable por significativas consecuencias psicosociales al paciente, caracterizado por la alteración negativa de la imagen corporal, culminando en depresión y aislamiento social<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B23"><sup>23</sup></xref>. Un estudio multicéntrico realizado en 36 países constató que este síntoma es un gran desafío durante la gestión de las heridas, siendo responsable de cerca del 80% de los pacientes con esas afecciones. Las mayores dificultades relatadas por los pacientes fueron el manejo del olor 83%; preocupaciones sociales 70%; dolor y contención de exudado 68%, seguida por estrés emocional 65%<xref ref-type="bibr" rid="B22"><sup>22</sup></xref>. De acuerdo con los hallazgos del estudio, la imposibilidad de frecuentar locales públicos ocurrió por la interferencia del olor en la imagen corporal del paciente y en la ansiedad de la percepción del mal olor a los demás.</p>
			<p>Los estudios refuerzan este hallazgo, ya que el mal olor se describe como la mayor causa de aflicción para los pacientes y de mayor dificultad de tratamiento<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B24"><sup>24</sup></xref>. Hay eminente constreñimiento a los individuos, además del refuerzo en cuanto a la concreción de la progresión de la enfermedad y de la pérdida del control sobre el cuerpo. El gran tiempo disponible para la realización de curativos, la dificultad en el acto de vestir y la imprevisibilidad en cuanto a la fuga de olor, principalmente, afectan el comportamiento relativo a la interacción social, influyendo de manera negativa en el bienestar del paciente<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B25"><sup>25</sup></xref>.</p>
			<p>Los sentimientos de vergüenza, disgusto, depresión y alteración negativa de la imagen corporal son aspectos relatados por autores que estudiaron la experiencia de convivir con la herida tumoral maligna<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B23"><sup>23</sup></xref>, resultando en impactos sociales devastadores, ya que el paciente puede presentar problemas psicológicos, principalmente relacionados con la ansiedad, por la preocupación en la percepción del mal olor por las personas con que convive, así como repercusiones sociales, resaltadas por el sentimiento de exclusión y bloqueo al contacto social<xref ref-type="bibr" rid="B23"><sup>23</sup></xref> comprometiendo el bienestar emocional y mental de los pacientes. En este estudio, se identificó una asociación del olor con el sentimiento de vergüenza y la imposibilidad del paciente en frecuentar lugares públicos, factores ligados al aislamiento social.</p>
			<p>Bajo esta perspectiva, dos investigaciones fenomenológicas indicaron el olor como principal síntoma que demanda de los pacientes diversas estrategias para esconderlo. La sensación eminente de fuga del olor, posibilidad de que otras personas puedan sentirlo y el enojo ajeno desencadenan problemas de ansiedad y vergüenza que, consecuentemente, limitan las actividades diarias. Además, la mano de obra intensiva demanda una cantidad inmensa de tiempo de limpieza de curativo de la herida, siendo entonces uno de los factores que contribuyen a que algunos participantes eviten frecuentar lugares públicos, aislándose en su domicilio<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B25"><sup>25</sup></xref>.</p>
			<p>Un estudio de meta-análisis mostró que el aislamiento social, la soledad y el vivir solo correspondieron a un promedio del 29%, el 26% y el 32% de aumento de probabilidad de mortalidad, respectivamente. Los resultados también difieren entre la edad de los participantes, con déficits sociales siendo más predictivos de muerte en muestras con una media de edad más joven de 65 años. En general, la influencia del aislamiento social en el riesgo de mortalidad es comparable con los factores de riesgo bien establecidos para la mortalidad<xref ref-type="bibr" rid="B26"><sup>26</sup></xref>. Bajo esta óptica, se sugiere que el aislamiento social promovido por el olor puede influir en la declinación de la supervivencia de los pacientes con HTM.</p>
			<p>La complejidad de las heridas crónicas en la enfermedad avanzada requiere avanzar en el pensamiento crítico y científico para auxiliar en la calidad de vida de los pacientes. Los métodos sistemáticos de evaluación multidisciplinar de las experiencias de los pacientes y de los problemas clínicos son necesarios, junto con estrategias de gestión eficaces, aunque reconociendo que es altamente individual la presentación de HTM<xref ref-type="bibr" rid="B2"><sup>2</sup></xref>. En una investigación realizada con 70 pacientes en Taiwán se evidenció por el análisis de regresión múltiple que el olor, el dolor y los problemas psicológicos fueron estadísticamente significativos para el déficit de la calidad de vida y responsable del 87% de la varianza<xref ref-type="bibr" rid="B27"><sup>27</sup></xref>. De esta forma, el constreñimiento y la imposibilidad a la convivencia social transmitida por el olor son determinantes que afectan la calidad de vida de los pacientes con esas afecciones.</p>
			<p>Además, el mal olor es citado por pacientes y cuidadores como uno de los aspectos más angustiosos, que interfiere la sociabilidad del portador. Sin embargo, el estudio constató que no hubo asociación significativa entre el olor y compromiso en la relación del paciente con sus familiares y amigos. La ausencia de un enfoque estandarizado para la evaluación y la gestión resalta la necesidad de recopilar datos básicos para apoyar el desarrollo de directrices<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B22"><sup>22</sup></xref> que incluyen la integración familiar en el cuidado a estos pacientes.</p>
			<p>Como se demuestra, los pacientes con heridas malolientes tienen necesidades físicas y psicológicas complejas. Las naturalezas psicosociales y espiritual del paciente son aspectos poco abordados por los profesionales de la salud, e incluso profesionales entrenados en cuidados paliativos presentan dificultad de analizar, abordar e integrar las diferentes dimensiones del ser humano, principalmente ante situaciones de finitud<xref ref-type="bibr" rid="B15"><sup>15</sup></xref>. En un estudio realizado con catorce enfermeras, se describieron ensayos de rabia, frustración, inadecuación, tristeza y culpa por no ser capaces de cuidar de sus pacientes con HTM de la manera que consideraban adecuada<xref ref-type="bibr" rid="B25"><sup>25</sup></xref>. Esto apunta a la necesidad de una profunda reflexión acerca de esta temática, además de incluirla en los contextos académicos y de entrenamiento profesional.</p>
			<p>Para el control de estos síntomas, además de realización de curativos adecuados a cada particularidad del paciente, es necesario el conocimiento de productos que objetivan minimizar los signos y síntomas presentes en la lesión. En cuanto al olor, el producto con más eficiencia es el metronidazol<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B24"><sup>24</sup></xref> responsable también del control bacteriano. Además, la implantación de productos que ejecutan el desbridamiento autolítico por medio de la utilización de agentes químicos, puede efectivamente suavizar y remover el tejido necrosado<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref>, principal responsable de la producción del olor<xref ref-type="bibr" rid="B28"><sup>28</sup></xref>. Los estudios nacionales demostraron que el Metronidazol gel es el más indicado y efectivo en el control y manejo del olor en HTM<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B29"><sup>29</sup></xref>. En este estudio, se utilizó el 0,8% de Metronidazol gel en todos los pacientes como medio de control del olor.</p>
			<p>El registro de enfermería en este ámbito es bastante incipiente, no habiendo un instrumento adecuadamente elaborado para las anotaciones sobre la herida tumoral, que presenta particularidades diferentes a las demás lesiones crónicas. Hay sugerencia de utilización de herramientas para la evaluación de la herida y sus signos y síntomas. En la práctica, las opiniones subjetivas de pacientes y cuidadores son los mejores indicadores para orientar las acciones de enfermería<xref ref-type="bibr" rid="B10"><sup>10</sup></xref>. Por lo tanto, es evidente la necesidad de elaborar directrices y protocolos interdisciplinarios que viabilicen una atención con más calidad y cohesión en las intervenciones destinada a cada paciente.</p>
			<p>El enfermero se destaca como agente de cuidados con el paciente con lesión, pues realiza diversos procedimientos técnicos, como el cambio de curativo<xref ref-type="bibr" rid="B30"><sup>30</sup></xref>. Además, permanece por períodos de tiempo con el paciente, sus cuidadores y/o familiares. Este escenario favorece la construcción y fortalecimiento de vínculo paciente-profesional de salud, lo que propicia la capacidad de detectar los anhelos psicológicos utilizando las posibilidades existentes en su proceso de cuidado para manejarlos, promoviendo confort y calidad de vida.</p>
			<p>Limitaciones del estudio</p>
			<p>Hubo limitaciones del estudio sobre el tamaño de la muestra, pues el escenario de investigación posee atención regionalizada, lo que dificultó el reclutamiento de pacientes de otras localidades. La ausencia de escalas que evalúen la interferencia del olor en la dinámica psicosocial de pacientes con esas lesiones trajo la necesidad de la construcción de una escala inédita en el área oncológica. Los resultados de esta investigación posibilitan la realización de otros estudios con el mismo tema, una vez que este tema carece de estudios de investigación a nivel nacional.</p>
			<p>Contribuciones para el área de enfermería</p>
			<p>El enfermero, como miembro del equipo multidisciplinar, realiza procedimientos que transcienden el manejo técnico. Considerar los anhelos psicológicos y sociales en el cuidado a los pacientes con HTM proporcionará una visión holística, aumentando la efectividad de la sistematización de la asistencia, cultivando, así, la dignidad al paciente oncológico. </p>
		</sec>
		<sec sec-type="conclusions">
			<title>CONCLUSIÓN</title>
			<p>El olor es la señal que puede favorecer directamente el aislamiento social en pacientes con HTM, siendo responsable de causar constreñimiento e impedir que los clientes frecuenten lugares públicos. Tales factores pueden estar relacionados entre sí, ya que el hecho de presentar constreñimiento ante el mal olor puede impedir la socialización del paciente. Además, se puede observar el agravio de la calidad de vida con el consiguiente deterioro del estado de salud, ya que esta variable puede producir ansiedad y depresión.</p>
			<p>El estudio piloto surge como sugerencia de cómo se pueden obtener, cuantitativamente, datos sobre posibles asociaciones de olores y factores que pueden contribuir al aislamiento social en pacientes con heridas tumorales, tanto por medio de la construcción de la escala Likert, como por la realización de procedimientos estadísticos para las relaciones de las variables por medio de un estudio más robusto.</p>
			<p>La enfermería actúa en el manejo y control de signos y síntomas de los pacientes con HTM. Además del conocimiento sobre las idiosincrasias de estas lesiones y de los productos adecuados a su cuidado, es fundamental que el profesional conozca la interferencia psicosocial que los signos y síntomas, sobre todo el olor pueden causar. De esta forma, el equipo podrá actuar de manera holística en el cuidado al paciente, viendo, además de los síntomas, sus anhelos psicológicos y sociales.</p>
		</sec>
	</body>
	<back>
		<ack>
			<title>Fomento</title>
			<p>Coordinación de Perfeccionamiento de Personal de Nivel Superior (CAPES) - Beca de maestría: 2014-2015; Consejo Nacional de Desarrollo Científico y Tecnológico (CNPQ): beca de fomento de investigación. Edital PIBIC/ CNPQ/ UFF 2015-2016.</p>
		</ack>
		<ref-list>
			<title>REFERENCIAS</title>
			<ref id="B1">
				<label>1</label>
				<mixed-citation>1. Aguiar RM, Silva GR. Os cuidados de enfermagem em feridas neoplásicas na assistência de enfermagem. Revista Hospital Universitário Pedro Ernesto [Internet]. 2012[cited 2016 June 15];11(2):82-8. Available from: <ext-link ext-link-type="uri" xlink:href="http://revista.hupe.uerj.br/detalhe_artigo.asp?id=331">http://revista.hupe.uerj.br/detalhe_artigo.asp?id=331</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Aguiar</surname>
							<given-names>RM</given-names>
						</name>
						<name>
							<surname>Silva</surname>
							<given-names>GR</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Os cuidados de enfermagem em feridas neoplásicas na assistência de enfermagem</article-title><bold>.</bold><source>Revista Hospital Universitário Pedro Ernesto</source>
					<comment>[Internet]</comment><bold>.</bold><year>2012</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>11</volume><bold>(</bold><issue>2</issue><bold>):</bold><fpage>82</fpage>
					<lpage>88</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://revista.hupe.uerj.br/detalhe_artigo.asp?id=331">http://revista.hupe.uerj.br/detalhe_artigo.asp?id=331</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B2">
				<label>2</label>
				<mixed-citation>2. Grocott P, Gethin G, Probst S. Malignant wound management in advanced illness: new insights. Curr Opin Support Palliat Care [Internet]. 2013[cited 2016 June 15];7(1):101-5. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/23254858">https://www.ncbi.nlm.nih.gov/pubmed/23254858</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Grocott</surname>
							<given-names>P</given-names>
						</name>
						<name>
							<surname>Gethin</surname>
							<given-names>G</given-names>
						</name>
						<name>
							<surname>Probst</surname>
							<given-names>S</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Malignant wound management in advanced illness: new insights</article-title><bold>.</bold><source>Curr Opin Support Palliat Care</source>
					<comment>[Internet]</comment><bold>.</bold><year>2013</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>7</volume><bold>(</bold><issue>1</issue><bold>):</bold><fpage>101</fpage>
					<lpage>105</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/23254858">https://www.ncbi.nlm.nih.gov/pubmed/23254858</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B3">
				<label>3</label>
				<mixed-citation>3. Maida V, Ennis M, Kuziemsky G, Trozzolo L. Symptoms Associated with Malignant Wounds: A Prospective Case Series. Journal of Pain and Symptom Management [Internet]. 2009[cited 2016 June 15];37 (2):206-11. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.vincentmaida.com/Publications/JPSM2009-206.pdf">http://www.vincentmaida.com/Publications/JPSM2009-206.pdf</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Maida</surname>
							<given-names>V</given-names>
						</name>
						<name>
							<surname>Ennis</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Kuziemsky</surname>
							<given-names>G</given-names>
						</name>
						<name>
							<surname>Trozzolo</surname>
							<given-names>L</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Symptoms Associated with Malignant Wounds: A Prospective Case Series</article-title><bold>.</bold><source>Journal of Pain and Symptom Management</source>
					<comment>[Internet]</comment>
					<year>2009</year>
					<bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>37</volume><bold>(</bold><issue>2</issue><bold>):</bold><fpage>206</fpage>
					<lpage>211</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.vincentmaida.com/Publications/JPSM2009-206.pdf">http://www.vincentmaida.com/Publications/JPSM2009-206.pdf</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B4">
				<label>4</label>
				<mixed-citation>4. Lo S, Hayter M, Hu W, Tai C, Hsu M, Li Y. Symptom burden and quality of life in patients with malignant fungating wounds. Journal of Advanced Nursing [Internet]. 2012[cited 2016 June 15];68(6):1312-21. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.pubpdf.com/pub/22043819/Symptom-burden-and-quality-of-life-in-patients-with-malignant-fungating-wounds">http://www.pubpdf.com/pub/22043819/Symptom-burden-and-quality-of-life-in-patients-with-malignant-fungating-wounds</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Lo</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Hayter</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Hu</surname>
							<given-names>W</given-names>
						</name>
						<name>
							<surname>Tai</surname>
							<given-names>C</given-names>
						</name>
						<name>
							<surname>Hsu</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Li</surname>
							<given-names>Y</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Symptom burden and quality of life in patients with malignant fungating wounds</article-title><bold>.</bold><source>Journal of Advanced Nursing</source>
					<comment>[Internet]</comment><bold>.</bold><year>2012</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>68</volume><bold>(</bold><issue>6</issue><bold>):</bold><fpage>1312</fpage>
					<lpage>1321</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.pubpdf.com/pub/22043819/Symptom-burden-and-quality-of-life-in-patients-with-malignant-fungating-wounds">http://www.pubpdf.com/pub/22043819/Symptom-burden-and-quality-of-life-in-patients-with-malignant-fungating-wounds</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B5">
				<label>5</label>
				<mixed-citation>5. Probst S, Arber A, Faithfull S. Malignant fungating wounds: the meaning of living in an unbounded body. European Journal of Oncology Nursing [Internet]. 2013[cited 2016 June 15];17:38-45. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.ejoncologynursing.com/article/S1462-3889(12)00019-1/abstract">http://www.ejoncologynursing.com/article/S1462-3889(12)00019-1/abstract</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Probst</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Arber</surname>
							<given-names>A</given-names>
						</name>
						<name>
							<surname>Faithfull</surname>
							<given-names>S</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Malignant fungating wounds: the meaning of living in an unbounded body</article-title><bold>.</bold><source>European Journal of Oncology Nursing</source>
					<comment>[Internet]</comment><bold>.</bold><year>2013</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>17</volume><bold>:</bold><fpage>38</fpage>
					<lpage>45</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.ejoncologynursing.com/article/S1462-3889(12)00019-1/abstract">http://www.ejoncologynursing.com/article/S1462-3889(12)00019-1/abstract</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B6">
				<label>6</label>
				<mixed-citation>6. Ponte D, Ferreira K, Costa N. O controlo do odor na ferida maligna. Journal of Tissue Regeneration Healing [Internet]. 2012[cited 2016 June 15];(1):38-43. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.trh-journal.com/o-controlo-do-odor/">http://www.trh-journal.com/o-controlo-do-odor/</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Ponte</surname>
							<given-names>D</given-names>
						</name>
						<name>
							<surname>Ferreira</surname>
							<given-names>K</given-names>
						</name>
						<name>
							<surname>Costa</surname>
							<given-names>N</given-names>
						</name>
					</person-group><bold>.</bold><article-title>O controlo do odor na ferida maligna</article-title><bold>.</bold><source>Journal of Tissue Regeneration Healing</source>
					<comment>[Internet]</comment><bold>.</bold><year>2012</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];(</bold><issue>1</issue><bold>):</bold><fpage>38</fpage>
					<lpage>43</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.trh-journal.com/o-controlo-do-odor/">http://www.trh-journal.com/o-controlo-do-odor/</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B7">
				<label>7</label>
				<mixed-citation>7. Recka K, Montagnini M, Vitale CA. Management of bleeding associated with malignant wounds. J Palliat Med [Internet]. 2012[cited 2016 June 15]; 15(8):952-4. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/22489879">https://www.ncbi.nlm.nih.gov/pubmed/22489879</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Recka</surname>
							<given-names>K</given-names>
						</name>
						<name>
							<surname>Montagnini</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Vitale</surname>
							<given-names>CA</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Management of bleeding associated with malignant wounds</article-title><bold>.</bold><source>J Palliat Med</source>
					<comment>[Internet]</comment>
					<year>2012</year>
					<bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold>
					<volume>15</volume>
					<issue>8</issue>
					<fpage>952</fpage>
					<lpage>954</lpage>
					<bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/22489879">https://www.ncbi.nlm.nih.gov/pubmed/22489879</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B8">
				<label>8</label>
				<mixed-citation>8. Woo KY, Sibbald RG. Local wound care for malignant and palliative wounds. Advances in skin and wound care [Internet]. 2010[cited 2016 June 15];23(9):417-28. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.manukahonning.no/uploads/3/9/6/3/39639435/_2010_local_wound_care_for_malignant_and_palliative_wounds.pdf">http://www.manukahonning.no/uploads/3/9/6/3/39639435/_2010_local_wound_care_for_malignant_and_palliative_wounds.pdf</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Woo</surname>
							<given-names>KY</given-names>
						</name>
						<name>
							<surname>Sibbald</surname>
							<given-names>RG</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Local wound care for malignant and palliative wounds</article-title><bold>.</bold><source>Advances in skin and wound care</source>
					<comment>[Internet]</comment><bold>.</bold><year>2010</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>23</volume><bold>(</bold><issue>9</issue><bold>):</bold><fpage>417</fpage>
					<lpage>428</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.manukahonning.no/uploads/3/9/6/3/39639435/_2010_local_wound_care_for_malignant_and_palliative_wounds.pdf">http://www.manukahonning.no/uploads/3/9/6/3/39639435/_2010_local_wound_care_for_malignant_and_palliative_wounds.pdf</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B9">
				<label>9</label>
				<mixed-citation>9. Gozzo TO, Tahan FP, Andrade M, Nascimento TG, Prado MAS. Ocorrência e manejo de feridas neoplásicas em mulheres com câncer de mama avançado. Esc Anna Nery [Internet]. 2014[cited 2016 June 15];18(2):270-6. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.scielo.br/pdf/ean/v18n2/1414-8145-ean-18-02-0270.pdf">http://www.scielo.br/pdf/ean/v18n2/1414-8145-ean-18-02-0270.pdf</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Gozzo</surname>
							<given-names>TO</given-names>
						</name>
						<name>
							<surname>Tahan</surname>
							<given-names>FP</given-names>
						</name>
						<name>
							<surname>Andrade</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Nascimento</surname>
							<given-names>TG</given-names>
						</name>
						<name>
							<surname>Prado</surname>
							<given-names>MAS</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Ocorrência e manejo de feridas neoplásicas em mulheres com câncer de mama avançado</article-title><bold>.</bold><source>Esc Anna Nery</source>
					<comment>[Internet]</comment><bold>.</bold><year>2014</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>18</volume><bold>(</bold><issue>2</issue><bold>):</bold><fpage>270</fpage>
					<lpage>276</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.scielo.br/pdf/ean/v18n2/1414-8145-ean-18-02-0270.pdf">http://www.scielo.br/pdf/ean/v18n2/1414-8145-ean-18-02-0270.pdf</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B10">
				<label>10</label>
				<mixed-citation>10. Draper C. The management of malodour and exudate in fungating wounds. British Journal of Nursing [Internet]. 2005[cited 2016 June 15];14(11): 4-12. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2005.14.Sup2.18210">http://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2005.14.Sup2.18210</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Draper</surname>
							<given-names>C</given-names>
						</name>
					</person-group><bold>.</bold><article-title>The management of malodour and exudate in fungating wounds</article-title><bold>.</bold><source>British Journal of Nursing</source>
					<comment>[Internet]</comment><bold>.</bold><year>2005</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>14</volume><bold>(</bold><issue>11</issue><bold>):</bold><fpage>4</fpage>
					<lpage>12</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2005.14.Sup2.18210">http://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2005.14.Sup2.18210</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B11">
				<label>11</label>
				<mixed-citation>11. Pantell M, Rehkopf D, Jutte D, Syme SL, Balmes J, Adler N. Social isolation: a predictor of mortality comparable to traditional clinical risk factors. American Journal of Public Health [Internet]. 2013[cited 2016 June 15];103(11):2056-62. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871270/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871270/</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Pantell</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Rehkopf</surname>
							<given-names>D</given-names>
						</name>
						<name>
							<surname>Jutte</surname>
							<given-names>D</given-names>
						</name>
						<name>
							<surname>Syme</surname>
							<given-names>SL</given-names>
						</name>
						<name>
							<surname>Balmes</surname>
							<given-names>J</given-names>
						</name>
						<name>
							<surname>Adler</surname>
							<given-names>N</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Social isolation: a predictor of mortality comparable to traditional clinical risk factors</article-title><bold>.</bold><source>American Journal of Public Health</source>
					<comment>[Internet]</comment><bold>.</bold><year>2013</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>103</volume><bold>(</bold><issue>11</issue><bold>):</bold><fpage>2056</fpage>
					<lpage>2062</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871270/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871270/</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B12">
				<label>12</label>
				<mixed-citation>12. Valtorta NK, Kanaan M, Gilbody S, Hanratty B. Loneliness, social isolation and social relationships: what are we measuring? A novel framework for classifying and comparing tools. BMJ Open [Internet]. 2016[cited 2016 June 15];6(4):e010799. Available from: <ext-link ext-link-type="uri" xlink:href="http://bmjopen.bmj.com/content/bmjopen/6/4/e010799.full.pdf">http://bmjopen.bmj.com/content/bmjopen/6/4/e010799.full.pdf</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Valtorta</surname>
							<given-names>NK</given-names>
						</name>
						<name>
							<surname>Kanaan</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Gilbody</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Hanratty</surname>
							<given-names>B</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Loneliness, social isolation and social relationships: what are we measuring? A novel framework for classifying and comparing tools</article-title><bold>.</bold><source>BMJ Open</source>
					<comment>[Internet]</comment><bold>.</bold><year>2016</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>6</volume><bold>(</bold><issue>4</issue><bold>):</bold><elocation-id>e010799</elocation-id><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://bmjopen.bmj.com/content/bmjopen/6/4/e010799.full.pdf">http://bmjopen.bmj.com/content/bmjopen/6/4/e010799.full.pdf</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B13">
				<label>13</label>
				<mixed-citation>13. Probst S, Arber A, Faithfull S. Coping with an exulcerated breast carcinoma: an interpretative phenomenological study. J Wound Care [Internet]. 2013[cited 2016 June 15]; 22(7):352-60. Available from: https://core.ac.uk/download/pdf/18322828.pdf</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Probst</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Arber</surname>
							<given-names>A</given-names>
						</name>
						<name>
							<surname>Faithfull</surname>
							<given-names>S</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Coping with an exulcerated breast carcinoma: an interpretative phenomenological study</article-title><bold>.</bold><source>J Wound Care</source>
					<comment>[Internet]</comment><bold>.</bold><year>2013</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>]; 22(7):352-60. Available from: https://core.ac.uk/download/pdf/18322828.pdf</bold></element-citation>
			</ref>
			<ref id="B14">
				<label>14</label>
				<mixed-citation>14. Castro MCF, Cruz PS, Grellmann MS, Santos WA, Fuly PSC. Palliative care for patients with oncological wounds in a teaching hospital: an experience report. Cogitare Enferm [Internet]. 2014[cited 2016 June 15];19(4): 841-4. Available from: <ext-link ext-link-type="uri" xlink:href="http://revistas.ufpr.br/cogitare/article/view/37294/23968">http://revistas.ufpr.br/cogitare/article/view/37294/23968</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Castro</surname>
							<given-names>MCF</given-names>
						</name>
						<name>
							<surname>Cruz</surname>
							<given-names>PS</given-names>
						</name>
						<name>
							<surname>Grellmann</surname>
							<given-names>MS</given-names>
						</name>
						<name>
							<surname>Santos</surname>
							<given-names>WA</given-names>
						</name>
						<name>
							<surname>Fuly</surname>
							<given-names>PSC</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Palliative care for patients with oncological wounds in a teaching hospital: an experience report</article-title><bold>.</bold><source>Cogitare Enferm</source>
					<comment>[Internet]</comment> 
					<year>2014</year>
					<bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold>
					<volume>19</volume>
					<bold>(</bold>
					<issue>4</issue>
					<bold>):</bold>
					<fpage>841</fpage>
					<lpage>844</lpage>
					<bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://revistas.ufpr.br/cogitare/article/view/37294/23968">http://revistas.ufpr.br/cogitare/article/view/37294/23968</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B15">
				<label>15</label>
				<mixed-citation>15. Castro MCF, Fuly PSC, Garcia TR, Santos MLSC. ICNP(r) terminological subgroup for palliative care patients with malignant tumor wounds. Acta Paulista de Enfermagem [Internet]. 2016[cited 2016 June 15]:29(3): 340-6. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.scielo.br/pdf/ape/v29n3/en_1982-0194-ape-29-03-0340.pdf">http://www.scielo.br/pdf/ape/v29n3/en_1982-0194-ape-29-03-0340.pdf</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Castro</surname>
							<given-names>MCF</given-names>
						</name>
						<name>
							<surname>Fuly</surname>
							<given-names>PSC</given-names>
						</name>
						<name>
							<surname>Garcia</surname>
							<given-names>TR</given-names>
						</name>
						<name>
							<surname>Santos</surname>
							<given-names>MLSC</given-names>
						</name>
					</person-group><bold>.</bold><article-title>ICNP(r) terminological subgroup for palliative care patients with malignant tumor wounds</article-title><bold>.</bold><source>Acta Paulista de Enfermagem</source>
					<comment>[Internet]</comment><bold>.</bold>
					<year>2016</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>]:</bold><volume>29</volume><bold>(</bold><issue>3</issue><bold>):</bold><fpage>340</fpage>
					<lpage>346</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.scielo.br/pdf/ape/v29n3/en_1982-0194-ape-29-03-0340.pdf">http://www.scielo.br/pdf/ape/v29n3/en_1982-0194-ape-29-03-0340.pdf</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B16">
				<label>16</label>
				<mixed-citation>16. Lund-nielsen B, Adamsen L, Gottup F, Rosth M, Tolver A, Kolms HJ.Qualitative bacteriology in malignant wounds--a prospective, randomized, clinical study to compare the effect of honey and silver dressings.Ostomy wound manage [Internet]. 2011[ cited 2016 June 15 ];57(2):28-6. Available from: http://www.o-wm.com/files/owm/pdfs/OWM_July2011_Lund-Nielsen.pdf</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Lund-nielsen</surname>
							<given-names>B</given-names>
						</name>
						<name>
							<surname>Adamsen</surname>
							<given-names>L</given-names>
						</name>
						<name>
							<surname>Gottup</surname>
							<given-names>F</given-names>
						</name>
						<name>
							<surname>Rosth</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Tolver</surname>
							<given-names>A</given-names>
						</name>
						<name>
							<surname>Kolms</surname>
							<given-names>HJ</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Qualitative bacteriology in malignant wounds--a prospective, randomized, clinical study to compare the effect of honey and silver dressings</article-title><bold>.</bold><source>Ostomy wound manage</source>
					<comment>[Internet]</comment><bold>.</bold><year>2011</year><bold>[ cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>57</volume><bold>(</bold><issue>2</issue><bold>):</bold><fpage>28</fpage>
					<lpage>26</lpage><bold>. Available from</bold><comment>Available from<ext-link ext-link-type="uri" xlink:href="http://www.o-wm.com/files/owm/pdfs/OWM_July2011_Lund-Nielsen.pdf">http://www.o-wm.com/files/owm/pdfs/OWM_July2011_Lund-Nielsen.pdf</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B17">
				<label>17</label>
				<mixed-citation>17. Probst S, Arber A, Faithfull S. Malignant fungating wounds: A survey of nurses' clinical practice in Switzerland. European Journal of Oncology Nursing [Internet]. 2009[cited 2016 June 15];13(4):295-8. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/19386546">https://www.ncbi.nlm.nih.gov/pubmed/19386546</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Probst</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Arber</surname>
							<given-names>A</given-names>
						</name>
						<name>
							<surname>Faithfull</surname>
							<given-names>S</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Malignant fungating wounds: A survey of nurses' clinical practice in Switzerland</article-title><bold>.</bold><source>European Journal of Oncology Nursing</source>
					<comment>[Internet].</comment>
					 <year>2009</year>
					 <bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold>
					 <volume>13</volume>
					 <bold>(</bold>
					 <issue>4</issue>
					 <bold>):</bold>
					 <fpage>295</fpage>
					<lpage>298</lpage>
					<bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/19386546">https://www.ncbi.nlm.nih.gov/pubmed/19386546</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B18">
				<label>18</label>
				<mixed-citation>18. Lo S, Hu W, Hayter M, Chang S, Hsu M, Wu L. Experiences of living with a malignant fungating wound: a qualitative study. J Clin Nurs [Internet]. 2008[cited 2016 June 15];17(20):2699-08. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/18808638">https://www.ncbi.nlm.nih.gov/pubmed/18808638</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Lo</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Hu</surname>
							<given-names>W</given-names>
						</name>
						<name>
							<surname>Hayter</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Chang</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Hsu</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Wu</surname>
							<given-names>L</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Experiences of living with a malignant fungating wound: a qualitative study</article-title><bold>.</bold><source>J Clin Nurs</source>
					<comment>[Internet]</comment><bold>.</bold><year>2008</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>17</volume><bold>(</bold><issue>20</issue><bold>):</bold><fpage>2699</fpage>
					<lpage>2608</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/18808638">https://www.ncbi.nlm.nih.gov/pubmed/18808638</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B19">
				<label>19</label>
				<mixed-citation>19. Probst S, Arber A, Trojan A, Faithfull S. Caring for a loved one with a malignant fungating wound. Support Care Cancer [Internet]. 2012[cited 2016 June 15];20(12):3065-70. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/22391594">https://www.ncbi.nlm.nih.gov/pubmed/22391594</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Probst</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Arber</surname>
							<given-names>A</given-names>
						</name>
						<name>
							<surname>Trojan</surname>
							<given-names>A</given-names>
						</name>
						<name>
							<surname>Faithfull</surname>
							<given-names>S</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Caring for a loved one with a malignant fungating wound</article-title><bold>.</bold><source>Support Care Cancer</source>
					<comment>[Internet].</comment>
					 <year>2012</year>
					 <bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>20</volume><bold>(</bold><issue>12</issue><bold>):</bold><fpage>3065</fpage>
					<lpage>3070</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/22391594">https://www.ncbi.nlm.nih.gov/pubmed/22391594</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B20">
				<label>20</label>
				<mixed-citation>20. Gibson S, Green J. Review of patients' experiences with fungating wounds and associated quality of life. Journal of wound care [Internet]. 2013[cited 2016 June 15];22(5):265-75. Available from:<ext-link ext-link-type="uri" xlink:href="https://www.researchgate.net/publication/236907711_Review_of_patients'_experiences_with_fungating_wounds_and_associated_quality_of_life">https://www.researchgate.net/publication/236907711_Review_of_patients'_experiences_with_fungating_wounds_and_associated_quality_of_life</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Gibson</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Green</surname>
							<given-names>J</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Review of patients' experiences with fungating wounds and associated quality of life</article-title><bold>.</bold><source>Journal of wound care</source>
					<comment>[Internet]</comment><bold>.</bold><year>2013</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>22</volume><bold>(</bold><issue>5</issue><bold>):</bold><fpage>265</fpage>
					<lpage>275</lpage><bold>. Available from:</bold><comment>Available from:<ext-link ext-link-type="uri" xlink:href="https://www.researchgate.net/publication/236907711_Review_of_patients'_experiences_with_fungating_wounds_and_associated_quality_of_life">https://www.researchgate.net/publication/236907711_Review_of_patients'_experiences_with_fungating_wounds_and_associated_quality_of_life</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B21">
				<label>21</label>
				<mixed-citation>21. Lisboa IND, Valença MP. Caracterização de pacientes com feridas neoplásicas. Estima [Internet]. 2016[cited 2017 Apr 05];14(1):21-8. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.revistaestima.com.br/index.php/estima/article/view/116/pdf">https://www.revistaestima.com.br/index.php/estima/article/view/116/pdf</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Lisboa</surname>
							<given-names>IND</given-names>
						</name>
						<name>
							<surname>Valença</surname>
							<given-names>MP</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Caracterização de pacientes com feridas neoplásicas</article-title><bold>.</bold><source>Estima</source>
					<comment>[Internet]</comment><bold>.</bold><year>2016</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>14</volume><bold>(</bold><issue>1</issue><bold>):</bold><fpage>21</fpage>
					<lpage>28</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.revistaestima.com.br/index.php/estima/article/view/116/pdf">https://www.revistaestima.com.br/index.php/estima/article/view/116/pdf</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B22">
				<label>22</label>
				<mixed-citation>22. Gethin G, Grocott P, Probst S, Clarke E. Current practice in the management of wound odour: an international survey. Int J Nurs Stud [Internet]. 2013[cited 2016 June 15];51(6):865-74. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.sciencedirect.com/science/article/pii/S0020748913003210">http://www.sciencedirect.com/science/article/pii/S0020748913003210</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Gethin</surname>
							<given-names>G</given-names>
						</name>
						<name>
							<surname>Grocott</surname>
							<given-names>P</given-names>
						</name>
						<name>
							<surname>Probst</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Clarke</surname>
							<given-names>E</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Current practice in the management of wound odour: an international survey</article-title><bold>.</bold><source>Int J Nurs Stud</source>
					<comment>[Internet]</comment><bold>.</bold><year>2013</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>51</volume><bold>(</bold><issue>6</issue><bold>):</bold><fpage>865</fpage>
					<lpage>874</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.sciencedirect.com/science/article/pii/S0020748913003210">http://www.sciencedirect.com/science/article/pii/S0020748913003210</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B23">
				<label>23</label>
				<mixed-citation>23. Dolbeault S, Flahault C, Baffie A, Fromantin I. Psychological profile of patients with neglected malignant wounds: a qualitative exploratory study. Journal of wound care [Internet]. 2014[cited 2016 June 15];19(12):513-21. Available from: Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/21160442">https://www.ncbi.nlm.nih.gov/pubmed/21160442</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Dolbeault</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Flahault</surname>
							<given-names>C</given-names>
						</name>
						<name>
							<surname>Baffie</surname>
							<given-names>A</given-names>
						</name>
						<name>
							<surname>Fromantin</surname>
							<given-names>I</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Psychological profile of patients with neglected malignant wounds: a qualitative exploratory study</article-title><bold>.</bold><source>Journal of wound care</source>
					<comment>[Internet]</comment><bold>.</bold><year>2014</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>19</volume><bold>(</bold><issue>12</issue><bold>):</bold><fpage>513</fpage>
					<lpage>521</lpage><bold>. Available from: Available from:</bold><comment>Available from: Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/21160442">https://www.ncbi.nlm.nih.gov/pubmed/21160442</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B24">
				<label>24</label>
				<mixed-citation>24. Alexander SJ. Malignant fungating wounds: key symptoms and psychosocial issues. Journal of wound care [Internet]. 2009[cited 2016 June 15];18(8):325-9. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/labs/articles/19862870/">https://www.ncbi.nlm.nih.gov/labs/articles/19862870/</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Alexander</surname>
							<given-names>SJ</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Malignant fungating wounds: key symptoms and psychosocial issues</article-title><bold>.</bold><source>Journal of wound care</source>
					<comment>[Internet]</comment><bold>.</bold><year>2009</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>18</volume><bold>(</bold><issue>8</issue><bold>):</bold><fpage>325</fpage>
					<lpage>329</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/labs/articles/19862870/">https://www.ncbi.nlm.nih.gov/labs/articles/19862870/</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B25">
				<label>25</label>
				<mixed-citation>25. Alexander SJ. An intense and unforgettable experience: the lived experience of malignant wounds from the perspectives of patients, caregivers and nurses. International Journal of Wound care [Internet]. 2010[cited 2016 June 15];7(6):456-65. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/20673255">https://www.ncbi.nlm.nih.gov/pubmed/20673255</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Alexander</surname>
							<given-names>SJ</given-names>
						</name>
					</person-group><bold>.</bold><article-title>An intense and unforgettable experience: the lived experience of malignant wounds from the perspectives of patients, caregivers and nurses</article-title><bold>.</bold><source>International Journal of Wound care</source>
					<comment>[Internet]</comment><bold>.</bold><year>2010</year><bold>[</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>7</volume><bold>(</bold><issue>6</issue><bold>):</bold><fpage>456</fpage>
					<lpage>465</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/20673255">https://www.ncbi.nlm.nih.gov/pubmed/20673255</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B26">
				<label>26</label>
				<mixed-citation>26. Holt-lunstad J, Smith TB, Baker M; Harris, T, Stephenson D. Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci [Internet]. 2015[cited 2016 June 15];10(2):227-37. Available from: <ext-link ext-link-type="uri" xlink:href="http://journals.sagepub.com/doi/pdf/10.1177/1745691614568352">http://journals.sagepub.com/doi/pdf/10.1177/1745691614568352</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Holt-lunstad J</surname>
							<given-names>Baker M</given-names>
						</name>
						<name>
							<surname>Harris</surname>
							<given-names>Stephenson D</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Loneliness and social isolation as risk factors for mortality: a meta-analytic review</article-title><bold>.</bold><source>Perspect Psychol Sci</source>
					<comment>[Internet]</comment><bold>.</bold><year>2015</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>10</volume><bold>(</bold><issue>2</issue><bold>):</bold><fpage>227</fpage>
					<lpage>237</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://journals.sagepub.com/doi/pdf/10.1177/1745691614568352">http://journals.sagepub.com/doi/pdf/10.1177/1745691614568352</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B27">
				<label>27</label>
				<mixed-citation>27. Lo SF, Hayter M, Hu WY, Tai CY, Hsu MY, Li YF. Symptom burden and quality of life in patients with malignant fungating wounds. Journal of Advanced Nursing [Internet]. 2012[cited 2016 June 15];68(6): 1312-21. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/22043819">https://www.ncbi.nlm.nih.gov/pubmed/22043819</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Lo</surname>
							<given-names>SF</given-names>
						</name>
						<name>
							<surname>Hayter</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Hu</surname>
							<given-names>WY</given-names>
						</name>
						<name>
							<surname>Tai</surname>
							<given-names>CY</given-names>
						</name>
						<name>
							<surname>Hsu</surname>
							<given-names>MY</given-names>
						</name>
						<name>
							<surname>Li</surname>
							<given-names>YF</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Symptom burden and quality of life in patients with malignant fungating wounds</article-title><bold>.</bold><source>Journal of Advanced Nursing</source>
					<comment>[Internet]</comment><bold>.</bold><year>2012</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>68</volume><bold>(</bold><issue>6</issue><bold>):</bold><fpage>1312</fpage>
					<lpage>1321</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/22043819">https://www.ncbi.nlm.nih.gov/pubmed/22043819</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B28">
				<label>28</label>
				<mixed-citation>28. Adderley UJ, Holt IGS. Topical agents and dressings for fungating wounds. Cochrane Database of Systematic Reviews [Internet]. 2014[cited 2016 June 15];5: 1-26. Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/17443534">https://www.ncbi.nlm.nih.gov/pubmed/17443534</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Adderley</surname>
							<given-names>UJ</given-names>
						</name>
						<name>
							<surname>Holt</surname>
							<given-names>IGS</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Topical agents and dressings for fungating wounds</article-title><bold>.</bold><source>Cochrane Database of Systematic Reviews</source>
					<comment>[Internet]</comment><bold>.</bold><year>2014</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2016-06-15">2016 June 15</date-in-citation><bold>];</bold><volume>5</volume><bold>:</bold><fpage>1</fpage>
					<lpage>26</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/pubmed/17443534">https://www.ncbi.nlm.nih.gov/pubmed/17443534</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B29">
				<label>29</label>
				<mixed-citation>29. Sacramento CJ, Reis PED, Simino GPR, Vasques CI. Manejo de sinais e sintomas em feridas tumorais: revisão integrativa. R. Enferm. Cent. O. Min [Internet]. 2015[cited 2017 Apr 05];5(1):1514-27. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.seer.ufsj.edu.br/index.php/recom/article/view/944/841">http://www.seer.ufsj.edu.br/index.php/recom/article/view/944/841</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Sacramento</surname>
							<given-names>CJ</given-names>
						</name>
						<name>
							<surname>Reis</surname>
							<given-names>PED</given-names>
						</name>
						<name>
							<surname>Simino</surname>
							<given-names>GPR</given-names>
						</name>
						<name>
							<surname>Vasques</surname>
							<given-names>CI</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Manejo de sinais e sintomas em feridas tumorais: revisão integrativa</article-title><bold>.</bold><source>R. Enferm. Cent. O. Min</source>
					<comment>[Internet]</comment><bold>.</bold><year>2015</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2017-04-05">2017 Apr 05</date-in-citation><bold>];</bold><volume>5</volume><bold>(</bold><issue>1</issue><bold>):</bold><fpage>1514</fpage>
					<lpage>1527</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.seer.ufsj.edu.br/index.php/recom/article/view/944/841">http://www.seer.ufsj.edu.br/index.php/recom/article/view/944/841</ext-link>
					</comment>
				</element-citation>
			</ref>
			<ref id="B30">
				<label>30</label>
				<mixed-citation>30. Santana AC, Bachion MM, Malaquias SG, Vieira F, Carneiro DA, Lima JR. Caracterização de profissionais de enfermagem que atendem pessoas com úlceras vasculares na rede ambulatorial. Revista Brasileira de Enfermagem [Internet]. 2013[cited 2017 Jan 15];66(6):822-826. Available from: <ext-link ext-link-type="uri" xlink:href="http://www.sci">http://www.sci</ext-link>
				</mixed-citation>
				<element-citation publication-type="journal"><bold>.</bold><person-group person-group-type="author">
						<name>
							<surname>Santana</surname>
							<given-names>AC</given-names>
						</name>
						<name>
							<surname>Bachion</surname>
							<given-names>MM</given-names>
						</name>
						<name>
							<surname>Malaquias</surname>
							<given-names>SG</given-names>
						</name>
						<name>
							<surname>Vieira</surname>
							<given-names>F</given-names>
						</name>
						<name>
							<surname>Carneiro</surname>
							<given-names>DA</given-names>
						</name>
						<name>
							<surname>Lima</surname>
							<given-names>JR</given-names>
						</name>
					</person-group><bold>.</bold><article-title>Caracterização de profissionais de enfermagem que atendem pessoas com úlceras vasculares na rede ambulatorial</article-title><bold>.</bold><source>Revista Brasileira de Enfermagem</source>
					<comment>[Internet]</comment><bold>.</bold><year>2013</year><bold>[cited</bold><date-in-citation content-type="access-date" iso-8601-date="2017-01-15">2017 Jan 15</date-in-citation><bold>];</bold><volume>66</volume><bold>(</bold><issue>6</issue><bold>):</bold><fpage>822</fpage>
					<lpage>826</lpage><bold>. Available from:</bold><comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.sci">http://www.sci</ext-link>
					</comment>
				</element-citation>
			</ref>
		</ref-list>
	</back>
	<!--
	<sub-article article-type="translation" id="s1" xml:lang="en">
		<front-stub>
			<article-categories>
				<subj-group subj-group-type="heading">
					<subject>Articles</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Association between odor and social isolation in patients with malignant tumor wounds: pilot study</article-title>
			</title-group>
			<abstract>
				<title>ABSTRACT:</title>
				<sec>
					<title>Objective</title>
					<p> To analysis associations between odor and social isolation in patients with malignant tumor wounds.</p>
				</sec>
				<sec>
					<title>Material and method</title>
					<p> A cross-sectional pilot study performed with nine patients with malignant tumor wounds treated at a university hospital from 2014 to 2016. Data were collected using a five-point likert scale for the evaluation of social isolation related to odor of malignant tumor wounds during nursing consultations. Data were analyzed by inferential statistical strategy with Spearman's coefficient at the significance level of 5% (α = 0.05).</p>
				</sec>
				<sec>
					<title>Results</title>
					<p> Correlation was found with statistical significance between odor and psychosocial dimensions: constraint and limitation in attending public places.</p>
				</sec>
				<sec>
					<title>Conclusion</title>
					<p> odor is the main symptom that causes embarrassment and limits social coexistence, favoring social isolation and degradation of the quality of life of cancer patients.</p>
				</sec>
			</abstract>
			<kwd-group xml:lang="en">
				<title>Key words:</title>
				<kwd>Oncology nursing</kwd>
				<kwd>Wounds and injuries</kwd>
				<kwd>Social isolation</kwd>
				<kwd>Palliative care</kwd>
				<kwd>Nursing</kwd>
			</kwd-group>
		</front-stub>
		<body>
			<sec sec-type="intro">
				<title>INTRODUCTION</title>
				<p>Malignant tumor wounds (MTW) affect approximately 5% to 10% of patients with neoplasias, being present, in the majority of cases, in the last six months of life<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B2"><sup>2</sup></xref>. However, in a more recent study the incidence of this lesion was observed in 14.5% of oncological individuals<xref ref-type="bibr" rid="B3"><sup>3</sup></xref>, being commonly associated with the primary or metastatic tumor<xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref>. The treatment is mainly palliative, in order to minimize signs and symptoms, in the light of promoting the improvement in the quality of life<xref ref-type="bibr" rid="B1"><sup>1</sup></xref>.</p>
				<p>These lesions are caused by the infiltration of malignant tumor cells into the skin's compositions. There is a breakdown in the integrity of the integument and, as a result of the disordered cell proliferation of the oncogenesis process, it culminates in the formation of the wound, progressively affecting the skin, disfiguring the body, becoming painful and with a foul smell<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B6"><sup>6</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B7"><sup>7</sup></xref>.</p>
				<p>Odor is considered a constant symptom in the daily life of patients with MTW, as one study found that 10.4% of odor cases are associated with these lesions<xref ref-type="bibr" rid="B3"><sup>3</sup></xref>. With the disordered and abnormal growth of the lesion, we have the formation of aggregates of necrotic tumor mass, where the contamination by aerobic (<italic>Pseudomonas aeruginosa</italic> and <italic>Staphylococcus aureus</italic>) and anaerobic microorganisms (bacteroides) occurs, obtaining as a product of their metabolism the volatile fatty acids (acetic, caproic acid), putrescine and cadaverine gases, which are responsible for the foul odor<xref ref-type="bibr" rid="B8"><sup>8</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref>. </p>
				<p>Such a situation is characterized as a major obstacle in the care process, because in addition to conferring bad smell on the patient and the people with whom they relate, it adds anguish in the progression of the disease, social and family restriction<xref ref-type="bibr" rid="B1"><sup>1</sup></xref>. Physiologically, the perception of bad odor is processed in the olfactory bulbs located in the brain, in the limbic and hypothalamic neural systems that are responsible for the motivational and emotional behavior. In addition, it gives patients unintended gagging triggered by the vomiting reflex, decreasing the sensation of taste and appetite, affecting the nutritional status. Therefore, the effects of odor are devastating on the patient's life, leading to nutritional, psychological stress and social isolation<xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref>. </p>
				<p>Social isolation is defined as a state in which the individual lacks a sense of social belonging, having disengagement of social bonds, institutional connections or community participation, being a potential predictor of mortality risk<xref ref-type="bibr" rid="B11"><sup>11</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B12"><sup>12</sup></xref>. Thus, multiprofessional care is important, since an holistic action can lead to improvement in the patient's self-esteem and quality of life, since bad odor is linked to this isolation<xref ref-type="bibr" rid="B13"><sup>13</sup></xref>.</p>
				<p>For the nursing team, there is great difficulty in controlling the symptoms related to the wound, highlighting the odor which, in most cases is reported as unpredictable and uncontrollable. This symptom is characterized as a great problem for the patient, imposing a situation of social isolation, further deteriorating their health condition<xref ref-type="bibr" rid="B5"><sup>5</sup></xref>. Thus, it is necessary to develop investigations for the construction and validation of protocols, with the objective of controlling the symptoms resulting from this type of injury, thus improving care and reducing the stress experienced by patients, family members and health professionals<xref ref-type="bibr" rid="B9"><sup>9</sup></xref>.</p>
				<p>Given the influence of odor on the psychosocial aspects of the patient with such lesions, as reported in the scientific literature and in the practice of care, the present study aims to identify possible associations between odor and factors that result in social isolation in patients with MTW.</p>
			</sec>
			<sec sec-type="methods">
				<title>METHODOLOGY</title>
				<p>The research is a subproject of the Casadinho Project UFF-USP, approved in public call MCT/CNPq/MEC/CAPES - Transversal Action no. 06/2011 - Casadinho/Procad: Innovation in Nursing in the treatment of tissue injuries - systematization, technological inclusion and functionality. </p>
				<p>It is a cross-sectional pilot study with a quantitative approach, carried out in the Palliative Care Outpatient Clinic of a University Hospital from September 2014 to January 2016.</p>
				<p>This outpatient clinic has been accredited as a high complexity unit in Oncology (UNACON) since 2009, being able to provide specialized and comprehensive assistance for the definitive diagnosis, treatment and follow-up of cancer<xref ref-type="bibr" rid="B14"><sup>14</sup></xref>. </p>
				<p>The present study is an extension of the research "Analysis of association of tumor wounds, primary site and demographic variables: implications for the systematization of nursing care", with the approval of the Ethics and Research Committee no. 183.757 on 01/11/2013.</p>
				<p>Population or sample: inclusion and exclusion criteria</p>
				<p>The convenience sample consisted of all patients with MTW who were attended on the study location during the study period and who met the following eligibility criteria: being over 18 years of age; having a diagnosis of cancer (any topography) at an advanced stage recorded in medical charts; presence of MTW classified in stage 1N or higher (since only superior to this stage the injury presents symptoms), of any topography; and manifesting authorization to participate in the research by signing the Informed Consent Form. Exclusion criterion was the presence of injuries from radiotherapy (radiodermatitis). The discontinuity criterion was the impossibility of participating in the nursing consultation for the exchange of dressings and the cases of death in the study period before the nursing consultation.</p>
				<p>Study protocol</p>
				<p>To perform the data collection, it was chosen the moment of the nursing consultation, with the consequent exchange of dressings, for analysis and completion of the data collection form, containing the following variables for collecting in medical records: sociodemographic (gender, age, ethnicity, schooling, marital status, working status) and clinical variables, during nursing consultation and medical records, such as clinical history, comorbidities, clinical diagnosis, primary tumor site, size, site, type of injury, staging, time of onset of the injury, treatment, products used and odor classification. </p>
				<p>The Odor Scale was applied for odor evaluation and classification as well as a Likert-type scale with 15 items, subdivided into three dimensions (wound, exudate and odor), with responses organized into a five-point scale (1 = not at all, 2 = a little, 3 = fairly, 4 = very much, 5 = completely) on the psychosocial aspects of the patient involving wounds and symptoms, with a maximum score of 75 points. In the study, only the dimension taken into account was the odor. </p>
				<p>For this dimension, the internal reliability was measured by Cronbach's Alpha Coefficient, considering a value above (0.7) as satisfactory. </p>
				<p>Likert rating scale</p>
				<p>The construction of the scale took four steps. In the first phase, an integrative review of the literature was carried out in order to verify the knowledge gaps in the context of neoplastic wounds. After tabulation of information, we identified that the symptoms are the main factors that jeopardize the quality of life and the psychosocial aspects of the patient with tumor injury, especially odor and exudate, with 90.69% and 100%, respectively, of the articles, as well as the isolation, which is described in 67.44% of the articles, generally associated with the fetid and exudative wounds.</p>
				<p>The second stage was a systematic investigation of the literature in the databases Lilacs, Medline and Cochrane with descriptors in health sciences (DeCs): <italic>odores; isolamento social; exsudatos</italic> and <italic>transudatos</italic> and the Medical Subject Headings Mesh Terms: exudates and transudates; social isolation, as well as with the keywords and <italic>palavras-chave</italic>: <italic>feridas neoplásicas; feridas tumorais</italic>; malodorous; psychological factors; psychosocial aspects; malignant wound; fungating wound; malignant fungating wound, with selection of 37 scientific evidences that allowed to find the theoretical construct about the social isolation in patients with odor and exudate in neoplastic wounds. All the articles were read in order to know the evidence about the phenomenon by mapping the main psychosocial factors compromised by odor and exudate in patients with neoplastic wounds. Each scientific reference was tabulated and grouped according to the evidenced psychosocial aspects. Afterwards, it was possible to establish three dimensions in the scale, each one with five items addressing different psychosocial areas: embarrassment, limitation in leaving home, limitation of relationship with the network of friends and family, limitation in attending public places. </p>
				<p>The items of the instrument were prepared in the form of closed questions with easy-to-read language in order to provide an adequate interpretation of the instrument and the collection of data. Thus, the scale was divided into three dimensions: wound, odor, and exudate, as well as the five common psychosocial factors, namely a) To what extent, to you, the odor exhaled through the wound is shameful? ; b) To what extent does the odor exhaled through the wound negatively interfere with you leaving the house?; c) To what extent does the odor exhaled through the wound negatively interfere with your relationship with your family? d) To what extent does the odor exhaled through the wound negatively interfere with your relationship with your friends?; e) To what extent does the odor exhaled through the wound cause you to avoid attending public places?, thus being the five items of each dimension of the scale. </p>
				<p>Likert-type or summed scales are characterized as psychometrics widely used in quantitative research that provide the interviewee with a quantitative indication of the degree of agreement or disagreement with the variables being evaluated. Numerical values are assigned to refer to the strength and direction of the marking.</p>
				<p>Analysis of results and statistics</p>
				<p>The data were tabulated in the Excel - Windows 2010 program, with statistical analysis performed using the Statistical Package for the Social Sciences (SPSS). The Shappiro-wilk normality test was used to verify whether the sample was parametric (p value&gt; 0.05) or non-parametric (p value ≤ 0.05). For the parametric variable, the data were presented as simple descriptive measures: mean and standard deviation ( x ±SD); for the non-parametric variables, the data were presented by the median and interquartile range ( x ± Q<sub>3</sub>-Q<sub>1</sub>). A Spearman correlation analysis and cross-frequency tables were performed between the odor grade and the five questions on the Likert scale of the odor dimension to verify the existence of an association between odor and factors favoring social isolation in patients with MTW. The correlation test was performed with 95% confidence and 0.05 significance.</p>
			</sec>
			<sec sec-type="results">
				<title>RESULTS</title>
				<p>The sample consisted of 77.78% (7) females and 22.22% (2) males aged between 29 and 74 years (mean = 59 years), all patients attending the first consultation or recurrent evaluation. A large portion of the participants were born in Rio de Janeiro and lived in the state of origin. With regard to schooling, it is observed that most of the participants have complete or incomplete elementary education 66.67% (6). The retired/pensioner labor status comprised 77.78% (7) of the sample, being characterized by age, length of service or illness. The amount of up to one minimum wage was responsible for the monthly income of 66.67% (6) of the patients. </p>
				<p>
					<table-wrap id="t5">
						<label>Table 1</label>
						<caption>
							<title>Distribution of sample data according to sociodemographic characteristics. Rio de Janeiro, Brazil, 2016.</title>
						</caption>
						<graphic xlink:href="1695-6141-eg-18-53-19-gt5.png"/>
					</table-wrap>
				</p>
				<p>Regarding the clinical variables, it is observed that 33.33% do not have any type of comorbidity, and 22.22% (2) have systemic arterial hypertension and 33.33% (3) type 2 diabetes. The most prevalent diagnosis was infiltrating ductal carcinoma, accounting for 44.44% (4) of the cases, followed by epidermoid carcinoma, with 22.22% (2). The primary site of pathological onset was mainly breasts, with 55.56% (5), and anal canal, with 22.22% (2).</p>
				<p>
					<table-wrap id="t6">
						<label>Table 2</label>
						<caption>
							<title>Distribution of the sample data according to their clinical characteristics. Rio de Janeiro, Brazil, 2016.</title>
						</caption>
						<table>
							<colgroup>
								<col/>
								<col/>
								<col/>
							</colgroup>
							<thead>
								<tr>
									<th align="left">Variable</th>
									<th align="center">N</th>
									<th align="center">%</th>
								</tr>
							</thead>
							<tbody>
								<tr>
									<td align="left">Diabetes</td>
									<td align="center">3</td>
									<td align="center">33.33</td>
								</tr>
								<tr>
									<td align="left">Systemic arterial hypertension </td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">Hepatical cirrhosis</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">None </td>
									<td align="center">3</td>
									<td align="center">33.33</td>
								</tr>
								<tr>
									<td align="left">Medical diagnosis</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Infiltrating ductal carcinoma</td>
									<td align="center">4</td>
									<td align="center">44.44</td>
								</tr>
								<tr>
									<td align="left">Adenocarcinoma of the endometrium</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Anal adenocarcinoma</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Metaplastic carcinoma</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Epidermoid carcinoma</td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">Squamous cell carcinoma</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Primary tumor site</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Breast </td>
									<td align="center">5</td>
									<td align="center">55.56</td>
								</tr>
								<tr>
									<td align="left">Anal canal</td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">Womb</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Tongue </td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
							</tbody>
						</table>
					</table-wrap>
				</p>
				<p>With the clinical data of the injury being available, the right breast was the site with the highest index of these injuries, responsible for 33.33% (3) of the phenomenon, followed by the left breast, with 22.22% (2), and the anal region, with 22.22% (2) of the cases. </p>
				<p>Based on the staging of the injury, it was possible to observe that 33.33% (3) were in stage 3 and 55.56% (5) were in stage 2. In addition, the circumstances of the appearance of MTW were also analyzed. Approximately 33.33% (3) of the injuries appeared after tumor resection surgery, of which 60% were in the form of a plastron. Approximately 22.22% (2) appeared after the biopsy and only 22.22% (2) spontaneously. </p>
				<p>
					<table-wrap id="t7">
						<label>Table 3</label>
						<caption>
							<title>Distribution of the sample data according to the clinical characteristics of the injury. Rio de Janeiro, Brazil, 2016.</title>
						</caption>
						<table>
							<colgroup>
								<col/>
								<col/>
								<col/>
							</colgroup>
							<thead>
								<tr>
									<th align="left">Variable</th>
									<th align="center">N</th>
									<th align="center">%</th>
								</tr>
								<tr>
									<th align="left">Injury site</th>
									<th align="center"> </th>
									<th align="center"> </th>
								</tr>
							</thead>
							<tbody>
								<tr>
									<td align="left">Left breast</td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">Right breast</td>
									<td align="center">3</td>
									<td align="center">33.33</td>
								</tr>
								<tr>
									<td align="left">Inguinal region</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Anal region</td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">Submandibular region</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Type of injury</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Malignant vegetative wound</td>
									<td align="center">4</td>
									<td align="center">44.44</td>
								</tr>
								<tr>
									<td align="left">Malignant fungating wound</td>
									<td align="center">5</td>
									<td align="center">55.56</td>
								</tr>
								<tr>
									<td align="left">Malignant fungating vegetative wound</td>
									<td align="center">0</td>
									<td align="center"></td>
								</tr>
								<tr>
									<td align="left">Staging</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">1N</td>
									<td align="center">0</td>
									<td align="center"></td>
								</tr>
								<tr>
									<td align="left">2</td>
									<td align="center">5</td>
									<td align="center">55.56</td>
								</tr>
								<tr>
									<td align="left">3</td>
									<td align="center">3</td>
									<td align="center">33.33</td>
								</tr>
								<tr>
									<td align="left">4</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">When did it appear?</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">After biopsy</td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">After surgery</td>
									<td align="center">3</td>
									<td align="center">33.33</td>
								</tr>
								<tr>
									<td align="left">Spontaneously</td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">Absent<sup>*</sup></td>
									<td align="center">2</td>
									<td align="center">22.22</td>
								</tr>
								<tr>
									<td align="left">Treatment</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Neo-adjuvant</td>
									<td align="center">3</td>
									<td align="center">33.33</td>
								</tr>
								<tr>
									<td align="left">Adjuvant</td>
									<td align="center">1</td>
									<td align="center">11.11</td>
								</tr>
								<tr>
									<td align="left">Palliative</td>
									<td align="center">5</td>
									<td align="center">55.56</td>
								</tr>
								<tr>
									<td align="left">Injury time</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">≤ 6 months</td>
									<td align="center">3</td>
									<td align="center">33.33</td>
								</tr>
								<tr>
									<td align="left">&gt; 6 months</td>
									<td align="center">6</td>
									<td align="center">66.67</td>
								</tr>
								<tr>
									<td align="left">Odor grade</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Grade 0</td>
									<td align="center">0</td>
									<td align="center"></td>
								</tr>
								<tr>
									<td align="left">Grade 1</td>
									<td align="center">5</td>
									<td align="center">55.56</td>
								</tr>
								<tr>
									<td align="left">Grade 2</td>
									<td align="center">4</td>
									<td align="center">44.44</td>
								</tr>
								<tr>
									<td align="left">Grade 3</td>
									<td align="center">0</td>
									<td align="center"></td>
								</tr>
							</tbody>
						</table>
						<table-wrap-foot>
							<fn id="TFN3">
								<p>* Information not found in medical records.</p>
							</fn>
						</table-wrap-foot>
					</table-wrap>
				</p>
				<p>The normality test was applied to the quantitative variables: injury size (p; 0.024), age (p; 0,156), total value of wound dimension (p; 0.001), total value of odor dimension (p; 0.027), total value of exudate dimension (p; 0.001). It was observed that only the age variable has a normal distribution. All analyzes that are performed will be non-parametric analyzes. The descriptive analysis was based in the median and in the difference between the third quartile and the first quartile. The total value of the odor dimension presented median = 8 and difference of quartile = 5. </p>
				<p>The Spearman correlation test showed the analyzes between the odor grade and their respective questions of odor dimension of the Likert ISPOE scale, in which there is a statistical correlation between odor and question one (addressing the constraint) (p = 0.0053) and question five (addressing the limitation of attending public places) (p; 0.0495). </p>
				<p>
					<table-wrap id="t8">
						<label>Table 4</label>
						<caption>
							<title>Frequency table and Spearman correlation analysis between odor grade and Likert scale issues of odor dimension. Rio de Janeiro, Brazil, 2016.</title>
						</caption>
						<graphic xlink:href="1695-6141-eg-18-53-19-gt8.png"/>
						<table-wrap-foot>
							<fn id="TFN4">
								<p>* Statistically significant</p>
							</fn>
						</table-wrap-foot>
					</table-wrap>
				</p>
				<p>The Cronbach's alpha coefficient of the Likert scale was evaluated, which obtained a value (0.88) for the dimension of the odor, being the internal reliability satisfactory. </p>
			</sec>
			<sec sec-type="discussion">
				<title>DISCUSSION</title>
				<p>The deficient scientific production on the psychosocial dimension of patients with MTW in the nursing area has demonstrated the importance of elaborating investigations on the subject, highlighting the importance of the professional in integrating this dimension in the process of systematization of care. Odor management is a great challenge for the multiprofessional team and for patients with tumor lesions, as it implies, in addition to a feeling of hopelessness in the team in achieving effective control of signs and symptoms, impact on the patient's life, determining the constant awareness of the progress of disease, distress and social isolation<xref ref-type="bibr" rid="B15"><sup>15</sup></xref>.</p>
				<p>Historically, the incidence of this condition has not been well documented, which makes it difficult to obtain official statistical data. Studies indicate that 5% to 10% of cancer patients are affected by these conditions<xref ref-type="bibr" rid="B16"><sup>16</sup></xref>. However, other studies indicate a prevalence of 14.5% of these injuries<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B17"><sup>17</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>. This shows the lack of consensus on the incidence of this injury.</p>
				<p>Regarding the age of the patients, it is evident that the elderly are more likely to develop MTW. The literature highlights that these injuries are predominant in patients aged 60-70 years, presenting lesions from breast cancer (62%), head and neck (24%) and genital and anal region (3%)<xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>. Data observed in the study identified that most of the sample presented age over 60 years, most of them females with injuries from breast cancer. </p>
				<p>Patient survival is currently a questionable factor. It is observed that those who present these injuries have a life survival of six months after their appearance<xref ref-type="bibr" rid="B2"><sup>2</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B19"><sup>19</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B20"><sup>20</sup></xref>. However, patients with greater survival time were found in the scientific literature. Research suggests that the increased life expectancy of patients with advanced cancer may be related to a significantly increased incidence of MTW<xref ref-type="bibr" rid="B13"><sup>13</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>, which brings the need for studies aimed at measuring these variables. </p>
				<p>Regarding the prevalence of this symptom in the MTW scenario, few studies have evaluated this context. An international study has found that about 10% of patients with these injuries have odor<xref ref-type="bibr" rid="B3"><sup>3</sup></xref>. In a Brazilian study with 51 oncologic patients with MTW, the odor was present in 72.5% of the sample<xref ref-type="bibr" rid="B21"><sup>21</sup></xref>. Despite the differences in incidence, this symptom is one of the most difficult to control, responsible for impairing the psychosocial quality of patients<xref ref-type="bibr" rid="B22"><sup>22</sup></xref>. </p>
				<p>The main objective of MTW care is the control of symptoms, and bad odor is responsible for significant psychosocial consequences to the patient, characterized by negative alteration of body image, culminating in depression and social isolation<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B23"><sup>23</sup></xref>. A multicenter study conducted in 36 countries found that this symptom is a major challenge during wound management, accounting for about 80% of patients with these conditions. The greatest difficulties reported by patients were odor management (83%); social concerns (70%); pain and containment of exudate (68%); followed by emotional stress (65%)<xref ref-type="bibr" rid="B22"><sup>22</sup></xref>. According to the study findings, the impossibility of attending public places was due to the interference of the odor in the patient's body image and the anxiety of others perceiving the odor. </p>
				<p>Studies reinforce this finding, since bad odor is described as the greatest cause of distress for patients and it is difficulty to treat<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B24"><sup>24</sup></xref>. There is constant embarrassment to individuals, as well as reinforcement regarding the progression of the disease and loss of control over the body. The great time available for dressings, the difficulty in dressing and the unpredictability of odor leakage mainly affect the behavior related to social interaction, negatively influencing the patient's well-being<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B25"><sup>25</sup></xref>.</p>
				<p>Feelings of shame, disgust, depression and negative change of the body image are aspects reported by authors who studied the experience of living with the malignant tumor wound<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B23"><sup>23</sup></xref>, resulting in devastating social impacts, since the patient may present psychological problems, mainly related to anxiety, concern about the perception of bad odor by the people with whom they interact, as well as social repercussions, highlighted by the feeling of exclusion and blockage to social contact<xref ref-type="bibr" rid="B23"><sup>23</sup></xref>, thus compromising the patients’ emotional and mental well-being. The study in question identified the association of odor with the feeling of shame and the impossibility of the patient to attend public places, factors related to the social isolation. </p>
				<p>From this perspective, two phenomenological studies have pointed to the odor as the main symptom that demands from the patients various strategies to conceal it. The constant sensation of odor leaking, the possibility that other people may feel it, and the alienation of others trigger anxiety and shame that consequently limit daily activities. In addition, the it demands an immense amount of time to cleanse wound dressing, and this is one of the factors that contribute to some participants avoiding going to public places, isolating themselves at home<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B25"><sup>25</sup></xref>. </p>
				<p>A meta-analysis study showed that social isolation, loneliness and living alone corresponded to an average of 29%, 26%, and 32% increased likelihood of mortality, respectively. The results also differ between participants' ages, with social deficits being more predictive of death in samples with a mean age younger than 65 years. In general, the influence of social isolation on mortality risk is comparable with well-established risk factors for mortality<xref ref-type="bibr" rid="B26"><sup>26</sup></xref>. From this perspective, the social isolation promoted by the odor may influence the decline of the survival of patients with MTW.</p>
				<p>The complexity of chronic wounds in advanced disease requires advancement in critical and scientific thinking to assist patients' quality of life. Systematic methods of multidisciplinary evaluation of patients' experiences and clinical problems are needed, along with effective management strategies, while recognizing that the appearance of MTW is highly individual<xref ref-type="bibr" rid="B2"><sup>2</sup></xref>. In a survey of 70 patients in Taiwan, multiple regression analysis showed that odor, pain, and psychological problems were statistically significant for quality of life deficits and accounted for 87% of the variance<xref ref-type="bibr" rid="B27"><sup>27</sup></xref>. Thus, the embarrassment and impossibility to social interaction deriving from the odor are determinant factors that affect the quality of life of the patients with these complications. </p>
				<p>In addition, the bad odor is cited by patients and caregivers as one of the most distressing aspects, which interferes with the sociability of the carrier. However, the study found that there was no significant association between odor and impairment in the patient's relationship with family and friends. The absence of a standardized approach for evaluation and management highlights the need to collect baseline data to support the development of guidelines<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B22"><sup>22</sup></xref> which include family integration in the care of these patients. </p>
				<p>As shown, patients with smelly wounds have complex physical and psychological needs. The psychosocial and spiritual natures of the patient are aspects little addressed by health professionals, and even professionals trained in palliative care have difficulty analyzing, approaching and integrating the different dimensions of the human being, especially in situations of finitude<xref ref-type="bibr" rid="B15"><sup>15</sup></xref>. In a study with fourteen nurses, feelings of anger, frustration, inadequacy, sadness, and guilt were described for not being able to care for their MTW patients in the way they thought it was adequate<xref ref-type="bibr" rid="B25"><sup>25</sup></xref>. This points to the need for a deep reflection on this subject, besides including it in the academic and professional training contexts.</p>
				<p>To control these symptoms, in addition to performing dressings appropriate to each particularity of the patient, it is necessary to know the products aimed at minimizing the signs and symptoms present in the injury. In terms of odor, the most effective product is metronidazole<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B24"><sup>24</sup></xref> responsible for bacterial control. In addition, the administration of products that perform autolytic debridement through the use of chemical agents can effectively soften and remove necrotic tissue<xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref>, the main responsible for the production of odor<xref ref-type="bibr" rid="B28"><sup>28</sup></xref>. National studies have shown that metronidazole gel is the most indicated and effective in controlling and managing odor in MTW<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B29"><sup>29</sup></xref><sup>)</sup> . In the study in question, 0.8% metronidazole gel was used in all patients as a way to control the odor. </p>
				<p>The nursing record in this field is very incipient, and there is no adequately elaborated instrument for the notes on the tumor wound that presents particularities different from the other chronic injuries. Some tools are suggested to evaluate the wound and its signs and symptoms. In practice, the subjective opinions of patients and caregivers are the best indicators to guide nursing actions<xref ref-type="bibr" rid="B10"><sup>10</sup></xref>. Thus, it is evident the need for the elaboration of guidelines and interdisciplinary protocols that enable a more quality service and cohesion in the interventions for each patient. </p>
				<p>The nurse stands out as an agent of care for the injured patient, since they performs several technical procedures, such as the exchange of dressing<xref ref-type="bibr" rid="B30"><sup>30</sup></xref>. In addition, they stay for long periods of time with the patient, their caregivers and/or family members. This scenario favors the construction and strengthening of the patient-health professional bond, which provides the capacity to detect psychological anxieties using the possibilities existing in their care process in order to manage them, promoting comfort and quality of life.</p>
				<p>Limitations of the study</p>
				<p>There were limitations of the study regarding the size of the sample, since the research scenario has a regional service, which made it difficult to recruit patients from other locations. The absence of scales that evaluate the interference of odor in the psychosocial dynamics of patients with these injuries has brought the need for constructing an unprecedented scale in the oncology area. The results of this research will allow the realization of other studies with the same theme, since the theme explored lacks research studies at the national level. </p>
				<p>Contributions to the nursing area</p>
				<p>The nurse, as a member of the multidisciplinary team, performs procedures that transcend technical handling. Addressing the psychological and social anxieties in the care of patients with MTW will provide a holistic view, increasing the effectiveness of systematization of care, thus cultivating the dignity of cancer patients. </p>
			</sec>
			<sec sec-type="conclusions">
				<title>CONCLUSION</title>
				<p>Odor is a sign that can directly favor social isolation in MTW patients and is responsible for causing embarrassment and preventing clients from attending public places. Such factors may be related to each other, since the fact of being embarrassed by the bad odor may impede the socialization of the patient. In addition, it can be observed the worsening of the quality of life with consequent deterioration of health status, since this variable can produce anxiety and depression. </p>
				<p>The pilot study appears as a suggestion of how data on possible associations of odor and factors that may contribute to social isolation in patients with tumor wounds can be quantitatively obtained, both by means of the construction of a Likert scale, and by performing statistical procedures for the relations of the variables by means of a more robust study. </p>
				<p>Nursing acts in the management and control of signs and symptoms of MTW patients. Besides knowledge about the idiosyncrasies of these injuries and the products suitable for their care, it is essential that the professional knows the psychosocial interference that signs and symptoms, especially odor, can cause. In this way, the team can act in a holistic way in patient care, focusing, in addition to the symptoms, their psychological and social longings. </p>
			</sec>
		</body>
		<back>
			<ack>
				<title>Support</title>
				<p>Coordination of Improvement of Higher Level Personnel (CAPES) - Master's degree scholarship: 2014-2015; National Council for Scientific and Technological Development (CNPQ): research grant. Notice PIBIC/CNPQ/UFF 2015-2016.</p>
			</ack>
		</back>
	</sub-article>
	<sub-article article-type="translation" id="s2" xml:lang="pt">
		<front-stub>
			<article-categories>
				<subj-group subj-group-type="heading">
					<subject>Articles</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Associação entre odor e isolamento social em pacientes com feridas tumorais malignas: estudo piloto</article-title>
			</title-group>
			<abstract>
				<title>RESUMO:</title>
				<sec>
					<title>Objetivo:</title>
					<p> Identificar as associações entre odor e isolamento social em pacientes com feridas tumorais malignas. </p>
				</sec>
				<sec>
					<title>Material e método:</title>
					<p> Estudo piloto com corte transversal realizado com nove pacientes com feridas tumorais malignas atendidos em um hospital universitário no período de 2014 a 2016. Coletaram-se dados por meio de aplicação de escala <italic>likert</italic> de cinco pontos para avaliação do isolamento social relacionado ao odor de feridas tumorais malignas, durante as consultas de enfermagem. Analisaram-se os dados por estratégia estatística inferencial com cálculo de coeficiente de <italic>Spearman</italic> ao nível de significância de 5% (α = 0,05). </p>
				</sec>
				<sec>
					<title>Resultados:</title>
					<p> Constatou-se correlação com significância estatística entre o odor e as dimensões psicossociais: constrangimento e limitação em frequentar locais públicos. </p>
				</sec>
				<sec>
					<title>Conclusão:</title>
					<p> O odor é o principal sintoma que gera constrangimento e limita a convivência social, favorecendo o isolamento social e a degradação da qualidade de vida dos pacientes oncológicos.</p>
				</sec>
			</abstract>
			<kwd-group xml:lang="pt">
				<title>Palavras-chave:</title>
				<kwd>Enfermagem oncológica</kwd>
				<kwd>Ferimentos e lesões</kwd>
				<kwd>Isolamento social</kwd>
				<kwd>Cuidados paliativos</kwd>
				<kwd>Enfermagem</kwd>
			</kwd-group>
		</front-stub>
		<body>
			<sec sec-type="intro">
				<title>INTRODUÇÃO</title>
				<p>As feridas tumorais malignas (FTM) acometem cerca de 5% a 10% dos pacientes com neoplasias, estando presentes, na maioria dos casos, nos últimos seis meses de vida<xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B2"><sup>2</sup></xref>. Todavia, em estudo mais recente é observado a incidência dessa lesão em 14,5% dos indivíduos oncológicos <xref ref-type="bibr" rid="B3"><sup>3</sup></xref>, sendo comumente ligadas ao tumor primário ou metastático <xref ref-type="bibr" rid="B4"><sup>4</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref>. O tratamento é efetuado majoritariamente de forma paliativa, a fim de minimizar sinais e sintomas, à luz de promover a melhora na qualidade de vida <xref ref-type="bibr" rid="B1"><sup>1</sup></xref>.</p>
				<p>Essas lesões são originadas pela infiltração das células malignas do tumor nas composições da pele. Há a quebra da integridade do tegumento e, em decorrência da proliferação celular desordenada do processo de oncogênese, culmina na formação da ferida, acometendo progressivamente a pele, desfigurando o corpo, tornando-se dolorosas e com odor fétido <xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B6"><sup>6</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B7"><sup>7</sup></xref>.</p>
				<p>O odor é considerado sintoma de presença constante no cotidiano dos pacientes com FTM, em que um estudo observou-se que 10,4% dos casos de odor estão associados a essas lesões<xref ref-type="bibr" rid="B3"><sup>3</sup></xref>. Com o crescimento desordenado e anormal da lesão, tem-se a formação de agregados de massa tumoral necrótica, onde ocorre a contaminação por micro-organismos aeróbicos (<italic>Pseudômonas aeruginosa e Staphylococcus aureus</italic>) e anaeróbicos (bacteroides), obtendo como produto do seu metabolismo os ácidos graxos voláteis (ácido acético, caproico), gases putrescina e cadaverina, que são responsáveis pelo odor fétido<xref ref-type="bibr" rid="B8"><sup>8</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref>. </p>
				<p>Tal situação é caracterizada como grande obstáculo no processo do cuidado, pois além de conferir mau cheiro ao paciente e as pessoas com quem se relaciona, acrescenta angústia no avanço da doença, restrição social e familiar<xref ref-type="bibr" rid="B1"><sup>1</sup></xref>. Fisiologicamente, a percepção do mau odor é processada nos bulbos olfativos localizadas no cérebro, nos sistemas neurais límbicos e hipotalâmicos que são responsáveis pelo comportamento motivacional e emocional. Além disso, gera aos pacientes engasgos involuntários desencadeados pelo reflexo do vômito, diminuindo a sensação de sabor e apetite, afetando o estado nutricional. Logo, os efeitos do odor são devastadores sobre a vida do paciente, levando ao estresse nutricional, psicológico e isolamento social<xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref>. </p>
				<p>O isolamento social é definido como estado em que o indivíduo carece de senso de pertencimento social, possuindo desengajamento de laços sociais, conexões institucionais ou participação da comunidade, sendo potencial preditor de risco de mortalidade<xref ref-type="bibr" rid="B11"><sup>11</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B12"><sup>12</sup></xref>. Dessa forma, é importante a atenção multiprofissional, pois a ação holística pode acarretar melhoria da autoestima e da qualidade de vida do paciente, uma vez que o mau odor está ligado a esse isolamento <xref ref-type="bibr" rid="B13"><sup>13</sup></xref>.</p>
				<p>Para a equipe de Enfermagem, há uma grande dificuldade no controle dos sintomas relacionados à ferida, destacando o odor que, na maioria das vezes é relatado como imprevisível e incontrolável. Esse sintoma se caracteriza como grande problema ao paciente, impondo uma situação de isolamento social, deteriorando ainda mais a sua condição de saúde<xref ref-type="bibr" rid="B5"><sup>5</sup></xref>. Sendo assim, é necessário o desenvolvimento de investigações para construção e validação protocolos, com o objetivo de controlar os sintomas decorrentes desse tipo de lesão, melhorando dessa forma o cuidado e diminuindo o estresse vivido pelos pacientes, familiares e profissionais de saúde <xref ref-type="bibr" rid="B9"><sup>9</sup></xref>.</p>
				<p>Tendo em vista a influência do odor sobre os aspectos psicossociais do paciente com tais lesões presentes na literatura científica e na prática do cuidado, o estudo tem por objetivo identificar as possíveis associações entre o odor e fatores que resultam em isolamento social em pacientes com FTM.</p>
			</sec>
			<sec sec-type="methods">
				<title>METODOLOGIA</title>
				<p>A pesquisa é um subprojeto do Projeto Casadinho UFF-USP, aprovado em chamada pública MCT/CNPq/MEC/CAPES ‒ Ação Transversal nº 06/2011 ‒ Casadinho/Procad: Inovação em Enfermagem no tratamento de lesões tissulares ‒ sistematização, inclusão tecnológica e funcionalidade. </p>
				<p>Trata-se de um estudo piloto transversal com abordagem quantitativa, realizado no Ambulatório de Cuidados Paliativos de um Hospital Universitário e executado no período de setembro de 2014 a janeiro de 2016.</p>
				<p>Esse ambulatório é habilitado como Unidade de Alta Complexidade em Oncologia (UNACON) desde 2009, estando habilitado a fornecer assistência especializada e integral para o diagnóstico definitivo, tratamento e acompanhamento de câncer<xref ref-type="bibr" rid="B14"><sup>14</sup></xref>. </p>
				<p>O estudo é uma extensão da pesquisa “Análise de associação de feridas tumorais, sítio primário e variáveis demográficas: implicações para a sistematização da assistência de enfermagem”, com aprovação do Comitê de ética e pesquisa nº 183.757 em 11/01/2013.</p>
				<p>População ou amostra: critérios de inclusão e exclusão</p>
				<p>A amostra de conveniência foi composta por todos os pacientes com FTM atendidos no local durante o período de estudo, que acataram aos seguintes critérios de elegibilidade: ser maior de 18 anos; ter diagnóstico de câncer (qualquer topografia) em estágio avançado registrado em prontuário; presença de FTM com classificada em estágio 1N ou superiores (uma vez que somente superior a esse estágio a lesão apresenta sintomas), de qualquer topografia, manifestando autorização em participar da pesquisa mediante a assinatura do Termo de Consentimento Livre e Esclarecido. Foi critério de exclusão: presença de lesões oriundas de tratamento radioterápico (radiodermite). Destaca-se que foi considerada como critério de descontinuidade a impossibilidade de participar da consulta de enfermagem para a troca de curativo e os casos de óbito no período do estudo antes da realização da consulta de enfermagem.</p>
				<p>Protocolo do estudo</p>
				<p>Para operacionalização da coleta dos dados foi instituído o momento da consulta de enfermagem, com consequente troca de curativos, para análise e preenchimento do formulário de coleta de dados, contendo as seguintes variáveis para coleta em prontuário: sociodemográficas (sexo, idade, etnia, escolaridade, estado civil, situação laboral) e clínicas, durante consulta de enfermagem e prontuário, tais como: história clínica, comorbidades, diagnóstico clínico, sítio primário tumoral, tamanho, local, tipo da lesão, estadiamento, tempo e momento de aparecimento da lesão, tratamento, produtos utilizados e classificação do odor. </p>
				<p>Foram aplicadas a Escala de Odor para avaliação e classificação de odor e o preenchimento de escala do tipo <italic>Likert,</italic> que é um instrumento composto por 15 itens, subdivido em 3 dimensões (ferida, exsudato e odor) com respostas organizadas em escala de cinco pontos (1 = nada, 2 = pouco, 3 = razoável, 4 = muito, 5 = totalmente) sobre os aspectos psicossociais do paciente envolvendo as feridas e os sintomas com pontuação máxima do instrumento de 75 pontos. No estudo, levou-se em consideração apenas a dimensão Odor. </p>
				<p>Mediu-se, para essa dimensão, a confiabilidade interna pelo Coeficiente de Alfa de <italic>Cronbach</italic>, considerando valor acima de (0,7) como satisfatório. </p>
				<p>Escala Likert de avaliação</p>
				<p>A construção da escala deu-se quatro etapas. Na primeira fase realizou-se uma revisão integrativa da literatura, a fim de verificar quais são as lacunas do conhecimento existentes no contexto das feridas neoplásicas. Após tabulação de informações identificou-se que os sintomas são os principais fatores que degradam a qualidade de vida e psicossocial do paciente com lesão tumoral, sobretudo o odor e exsudato, com respectivamente 90,69% e 100% dos artigos, bem como o isolamento social que é descrito em 67,44% dos artigos, geralmente associadas ao acometimento de feridas fétidas e exsudativas.</p>
				<p>Em segunda etapa constituiu na realização de uma investigação sistemática da literatura nas bases da dados Lilacs, Medline e Cochrane com os descritores em ciências da saúde (DeCs): odores; isolamento social; exsudatos e transudatos e Medical Subject Headings Mesh Terms: exudates and transudates; social isolation, bem como com as palavras-chave e keywords: feridas neoplásicas, feridas tumorais, malodorous; psychological factors; psychosocial aspects; malignant wound; fungating wound; malignant fungating wound. com seleção de 37 evidências científicas que possibilitou encontrar o construto teórico sobre o isolamento social em pacientes com odor e exsudato em feridas neoplásicas. Realizou-se a leitura de todos os artigos a fim de conhecer as evidências sobre o fenômeno efetuando o mapeamento dos principais fatores psicossociais comprometidos pelo odor e exsudato em pacientes com feridas neoplásicas. Cada referência científica foi tabulada e agrupada de acordo com os aspectos psicossociais evidenciados. Na sequência, foi possível estabelecer três dimensões na escala, contando para cada um com cinco itens abordando áreas psicossociais distintas: constrangimento, limitação em sair de casa, limitação de relacionamento com a rede de amigos e familiares, limitação em frequentar locais públicos. </p>
				<p>Os itens do instrumento foram elaborados em forma de perguntas fechadas com linguagem de fácil acesso, a fim de proporcionar uma adequada interpretação do instrumento e a obtenção de dados. Com isso, a escala foi dividida em três dimensões: ferida, odor e exsudato, bem como os cinco fatores psicossociais em comum, os quais foram determinados: a) Até que ponto, para você, o mau cheiro exalado através da ferida é vergonhoso?; b) Até que ponto o mau cheiro exalado através da ferida interfere negativamente em você sair de casa?; c) Até que ponto o mau cheiro exalado através da ferida interfere negativamente o seu relacionamento com sua família? d) Até que ponto o mau cheiro exalado através da ferida interfere negativamente o seu relacionamento com seus amigos? e) Até que ponto o mau cheiro exalado através da ferida faz com que você evite frequentar locais públicos?, sendo, assim, os cinco itens de cada dimensão da escala.</p>
				<p>As escalas do tipo Likert ou escalas somadas são caracterizadas como psicométricas amplamente utilizadas em pesquisas quantitativas que proporcionam ao entrevistado a indicação quantitativa do grau de concordância ou discordância frente às variáveis que estão sendo avaliadas. Atribuem-se valores numéricos para referir à força e a direção da marcação.</p>
				<p>Análise dos resultados e estatística</p>
				<p>Os dados foram tabulados no programa Excel - Windows 2010, com posterior emprego da análise estatística realizada com auxílio do <italic>Statistical Package for the Social Sciences</italic> (SPSS). Aplicou-se o teste de normalidade <italic>Shappiro - wilk</italic>, para a verificação se a amostra é paramétrica (p valor &gt; 0,05) ou não paramétrica (p valor ≤ 0,05). Para a variável paramétrica, os dados foram apresentados sob a forma de medidas descritivas simples: média e desvio padrão ( x ±D.P), já para as variáveis não paramétricas os dados foram apresentados pela mediana e intervalo interquartil ( x ± Q<sub>3</sub>-Q<sub>1</sub>). Efetuou-se uma análise de correlação de <italic>Spearman</italic> e tabelas de frequência cruzadas entre o grau de odor com as cinco questões da escala <italic>likert</italic> da dimensão odor para verificar a existência de associação entre o odor e fatores que favorecem o isolamento social em pacientes com FTM. O teste de correlação foi realizado com 95% de confiança e 0,05 de significância.</p>
			</sec>
			<sec sec-type="results">
				<title>RESULTADOS</title>
				<p>A amostra foi composta por 77,78% (7) do sexo feminino e 22,22% (2) do sexo masculino com idade entre 29 e 74 anos (média = 59 anos) por pacientes atendidos pela enfermagem na primeira consulta ou avaliação recorrente. Grande parcela dos participantes é nascida no Rio de Janeiro, domiciliados no estado de origem. Com relação à escolaridade, observa-se que a maioria dos participantes possui ensino fundamental completo ou incompleto 66,67% (6). O estado laboral aposentado/pensionista comportou 77.78% (7) da amostra, sendo caracterizado por idade, tempo de serviço ou doença. O quantitativo de até um salário mínimo foi responsável pela renda mensal de 66,67% (6) dos pacientes. </p>
				<p>
					<table-wrap id="t9">
						<label>Tabela 1</label>
						<caption>
							<title>Distribuição dos dados da amostra segundo as suas características sociodemográficas. Rio de Janeiro, Brasil, 2016.</title>
						</caption>
						<graphic xlink:href="1695-6141-eg-18-53-19-gt9.png"/>
					</table-wrap>
				</p>
				<p>No que tange as variáveis clínicas, observa-se que 33,33% não possuem qualquer tipo de comorbidade, sendo que 22,22% (2) contém hipertensão arterial sistêmica e 33,33% (3) diabetes do tipo 2. O diagnóstico médico mais prevalente foi o de carcinoma ductal infiltrante, responsável por 44,44% (4) dos casos, seguido de carcinoma epidermoide com 22,22% (2). O sítio primário de surgimento patológico foi principalmente em mama 55,56% (5) e canal anal 22,22% (2).</p>
				<p>
					<table-wrap id="t10">
						<label>Tabela 2</label>
						<caption>
							<title>Distribuição dos dados da amostra segundo as suas características clínicas. Rio de Janeiro, Brasil, 2016.</title>
						</caption>
						<table>
							<colgroup>
								<col/>
								<col/>
								<col/>
							</colgroup>
							<thead>
								<tr>
									<th align="left">Variáveis</th>
									<th align="center">N</th>
									<th align="center">%</th>
								</tr>
							</thead>
							<tbody>
								<tr>
									<td align="left">Diabetes</td>
									<td align="center">3</td>
									<td align="center">33,33</td>
								</tr>
								<tr>
									<td align="left">Hipertensão arterial sistêmica </td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Cirrose hepática</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Não há </td>
									<td align="center">3</td>
									<td align="center">33,33</td>
								</tr>
								<tr>
									<td align="left">Diagnóstico médico</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Carcinoma ductal infiltrante</td>
									<td align="center">4</td>
									<td align="center">44,44</td>
								</tr>
								<tr>
									<td align="left">Adenocarcinoma de endométrio</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Adenocarcinoma anal</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Carcinoma metaplásico</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Carcinoma epidermoide</td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Carcinoma escamoso</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Sítio primário tumoral</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Mama </td>
									<td align="center">5</td>
									<td align="center">55,56</td>
								</tr>
								<tr>
									<td align="left">Canal anal </td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Útero </td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Língua </td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
							</tbody>
						</table>
					</table-wrap>
				</p>
				<p>Dispondo-se dos dados clínicos da lesão, a mama direita foi o local onde comportou maior índice dessas lesões, sendo responsáveis por 33,33% (3) do fenômeno, em mama esquerda observou-se 22,22% (2) e região anal 22,22% (2) dos casos. </p>
				<p>Com base no estadiamento da lesão, foi possível observar que 33,33% (3) se enquadravam na categoria 3 e 55,56% (5) das lesões estavam em estadiamento 2. Além disso, as circunstâncias do surgimento da FTM também estão sendo analisadas, cerca de 33,33% (3) das lesões surgiram após a cirurgia de ressecção do tumor, sendo dessas 60% na forma de plastão. Aproximadamente 22,22% (2) apareceram após a realização de biópsia e somente 22,22% (2) espontaneamente.</p>
				<p>
					<table-wrap id="t11">
						<label>Tabela 3 </label>
						<caption>
							<title>Distribuição dos dados da amostra segundo as suas características clínicas da lesão. Rio de Janeiro, Brasil, 2016.</title>
						</caption>
						<table>
							<colgroup>
								<col/>
								<col/>
								<col/>
							</colgroup>
							<thead>
								<tr>
									<th align="left">Variáveis</th>
									<th align="center">N</th>
									<th align="center">%</th>
								</tr>
								<tr>
									<th align="left">Local da lesão</th>
									<th align="center"> </th>
									<th align="center"> </th>
								</tr>
							</thead>
							<tbody>
								<tr>
									<td align="left">Mama esquerda</td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Mama direita</td>
									<td align="center">3</td>
									<td align="center">33,33</td>
								</tr>
								<tr>
									<td align="left">Região inguinal</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Região anal</td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Região submandibular</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Tipo de lesão</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Ferida vegetante maligna</td>
									<td align="center">4</td>
									<td align="center">44,44</td>
								</tr>
								<tr>
									<td align="left">Ferida ulcerativa maligna</td>
									<td align="center">5</td>
									<td align="center">55,56</td>
								</tr>
								<tr>
									<td align="left">Ferida vegetante maligna ulcerada</td>
									<td align="center">0</td>
									<td align="center"></td>
								</tr>
								<tr>
									<td align="left">Estadiamento</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">1N</td>
									<td align="center">0</td>
									<td align="center"></td>
								</tr>
								<tr>
									<td align="left">2</td>
									<td align="center">5</td>
									<td align="center">55,56</td>
								</tr>
								<tr>
									<td align="left">3</td>
									<td align="center">3</td>
									<td align="center">33,33</td>
								</tr>
								<tr>
									<td align="left">4</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Quando surgiu?</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Após biópsia </td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Após cirurgia </td>
									<td align="center">3</td>
									<td align="center">33,33</td>
								</tr>
								<tr>
									<td align="left">Espontaneamente</td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Ausente<sup>*</sup></td>
									<td align="center">2</td>
									<td align="center">22,22</td>
								</tr>
								<tr>
									<td align="left">Tratamento</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Neoadjuvante</td>
									<td align="center">3</td>
									<td align="center">33,33</td>
								</tr>
								<tr>
									<td align="left">Adjuvante</td>
									<td align="center">1</td>
									<td align="center">11,11</td>
								</tr>
								<tr>
									<td align="left">Paliativo</td>
									<td align="center">5</td>
									<td align="center">55,56</td>
								</tr>
								<tr>
									<td align="left">Tempo de lesão</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">≤ 6 meses</td>
									<td align="center">3</td>
									<td align="center">33,33</td>
								</tr>
								<tr>
									<td align="left">&gt; 6 meses</td>
									<td align="center">6</td>
									<td align="center">66,67</td>
								</tr>
								<tr>
									<td align="left">Grau de odor</td>
									<td align="center"> </td>
									<td align="center"> </td>
								</tr>
								<tr>
									<td align="left">Grau 0</td>
									<td align="center">0</td>
									<td align="center"></td>
								</tr>
								<tr>
									<td align="left">Grau 1</td>
									<td align="center">5</td>
									<td align="center">55,56</td>
								</tr>
								<tr>
									<td align="left">Grau 2</td>
									<td align="center">4</td>
									<td align="center">44,44</td>
								</tr>
								<tr>
									<td align="left">Grau 3</td>
									<td align="center">0</td>
									<td align="center"<name /></td>
								</tr>
							</tbody>
						</table>
						<table-wrap-foot>
							<fn id="TFN5">
								<p>*Informação não encontrada em prontuários.</p>
							</fn>
						</table-wrap-foot>
					</table-wrap>
				</p>
				<p>Aplicou-se o teste de normalidade nas variáveis quantitativas: tamanho da lesão (p; 0,024), idade (p; 0,156), valor total da dimensão ferida (p; 0,001), valor total da dimensão odor (p; 0,027) e valor total da dimensão exsudato (p; 0,001). Observou-se que apenas a variável idade possui distribuição normal. Todas as análises que forem realizadas serão análises não paramétricas. A análise descritiva se baseou na mediana e na diferença entre o terceiro quartil e o primeiro quartil. O valor total da dimensão Odor apresentou mediana = 8 e diferença de quartil = 5.</p>
				<p>O teste de correlação de <italic>Spearman</italic> evidenciou que as análises entre grau de odor e suas respectivas questões da dimensão odor da escala <italic>likert</italic> ISPOE, em que há correlação estatística entre o odor e a questão um (aborda o constrangimento) (p; 0,0053) e a questão cinco (aborda a limitação em frequentar locais públicos) (p; 0,0495). </p>
				<p>
					<table-wrap id="t12">
						<label>Tabela 4</label>
						<caption>
							<title>Tabela de frequência e análise de correlação de Spearman entre o grau de odor e as questões da escala likert da dimensão odor. Rio de Janeiro, Brasil, 2016.</title>
						</caption>
						<graphic xlink:href="1695-6141-eg-18-53-19-gt12.png"/>
						<table-wrap-foot>
							<fn id="TFN6">
								<p>*Estatisticamente significativo</p>
							</fn>
						</table-wrap-foot>
					</table-wrap>
				</p>
				<p>Efetuou-se a avaliação do Coeficiente do Alfa de <italic>Cronbach</italic> da escala Likert que obteve valor (0,88) para a dimensão do odor, sendo satisfatória a confiabilidade interna. </p>
			</sec>
			<sec sec-type="discussion">
				<title>DISCUSSÃO</title>
				<p>A deficiente produção científica sobre a dimensão psicossocial dos pacientes com FTM na área da Enfermagem tem demonstrado a relevância de elaboração de investigações sobre o assunto, destacando a importância do profissional em integrar essa dimensão no processo da sistematização do cuidado. O manejo do odor é um grande desafio para a equipe multiprofissional e portadores de lesões tumorais, pois implica, além de sentimento de desesperança na equipe em alcançar o controle eficaz dos sinais e sintomas, impacto na vida do paciente, determinando a conscientização constante do avanço da doença, angústia e isolamento social <xref ref-type="bibr" rid="B15"><sup>15</sup></xref>.</p>
				<p>Historicamente, a incidência dessa condição não é bem documentada, o que dificulta a obtenção dados estatísticos oficiais. Estudos apontam que 5% a 10% dos pacientes oncológicos são acometidos por essas afecções <xref ref-type="bibr" rid="B16"><sup>16</sup></xref>. No entanto, outras pesquisas apontam prevalência de 14,5% dessas lesões <xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B17"><sup>17</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>. Isso mostra a inexistência de um consenso sobre a incidência dessa lesão.</p>
				<p>No que tange a faixa etária dos pacientes, é evidente que os idosos apresentam maior propensão em desenvolver as FTM. A literatura destaca que essas lesões são predominantes em pacientes com idade entre 60-70 anos, apresentando lesões oriundas de câncer de mama (62%), cabeça e pescoço (24%) e região genital e anal (3%) <xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>. Dados observados no estudo identificou que grande parte amostra apresentou idade superior a 60 anos, sendo maioria do sexo feminino com lesões oriundas de câncer de mama. </p>
				<p>A sobrevida do paciente é um fator questionável atualmente. Observa-se que aqueles que apresentam essas lesões possuem uma sobrevida de seis meses de vida após o seu aparecimento <xref ref-type="bibr" rid="B2"><sup>2</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B19"><sup>19</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B20"><sup>20</sup></xref>. Porém, no estudo em questão, constataram-se pacientes com sobrevida acima do período observado na literatura científica. Pesquisas sugerem que o aumento da expectativa de vida de pacientes com câncer avançado pode estar relacionado ao aumentado significativo da incidência de FTM <xref ref-type="bibr" rid="B13"><sup>13</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref>, emergindo a necessidade de estudos que visem mensurar essas variáveis. </p>
				<p>Em relação à prevalência desse sintoma no cenário das FTM, há poucos estudos que avaliaram tal contexto. Um estudo internacional verificou-se que cerca de 10% dos pacientes com essas lesões apresentam odor <xref ref-type="bibr" rid="B3"><sup>3</sup></xref>. Já em um estudo brasileiro realizado com 51 pacientes oncológicos portadores de FTM, o odor esteve presente em 72,5% da amostra <xref ref-type="bibr" rid="B21"><sup>21</sup></xref>. Apesar das divergências em relação à incidência, esse sintoma é um dos mais difíceis de obter controle, responsável por deteriorar a qualidade psicossocial dos pacientes com essas lesões <xref ref-type="bibr" rid="B22"><sup>22</sup></xref>. </p>
				<p>O principal objetivo do cuidado às FTM é o controle dos sintomas, sendo o mau odor responsável por significativas consequências psicossociais ao paciente, caracterizado pela alteração negativa da imagem corporal, culminando em depressão e isolamento social <xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B23"><sup>23</sup></xref>. Um estudo multicêntrico realizado em 36 países constatou que esse sintoma é um grande desafio durante a gestão das feridas, sendo responsável por cerca de 80% dos pacientes com essas afecções. As maiores dificuldades relatadas pelos pacientes foram o manejo do odor 83%; preocupações sociais 70%; dor e contenção de exsudato 68%, seguida por estresse emocional 65% <xref ref-type="bibr" rid="B22"><sup>22</sup></xref>. De acordo com os achados do estudo, a impossibilidade de frequentar locais públicos ocorreu pela interferência do odor na imagem corporal do paciente e na ansiedade da percepção do mau cheiro pelos outros. </p>
				<p>Estudos reforçam esse achado, já que o mau odor é descrito como a maior causa de aflição para os pacientes e de maior dificuldade de tratamento <xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B24"><sup>24</sup></xref>. Há eminente constrangimento aos indivíduos, além do reforço quanto à concretização da progressão da doença e da perda do controle sobre o corpo. O grande tempo disponibilizado à realização de curativos, a dificuldade no ato de se vestir e a imprevisibilidade quanto ao vazamento de odor, principalmente, afetam o comportamento relativo à interação social, influenciando de maneira negativa o bem-estar do paciente <xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B25"><sup>25</sup></xref>.</p>
				<p>Sentimentos de vergonha, desgosto, depressão e alteração negativa da imagem corporal são aspectos relatados por autores que estudaram a experiência de conviver com a ferida tumoral maligna <xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B18"><sup>18</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B23"><sup>23</sup></xref>, resultando em impactos sociais devastadores, uma vez que o paciente pode apresentar problemas psicológicos, principalmente relacionados à ansiedade, pela preocupação na percepção do mau odor pelas pessoas com que convive, bem como repercussões sociais, salientados pelo sentimento de exclusão e bloqueio ao contato social <xref ref-type="bibr" rid="B23"><sup>23</sup></xref> comprometendo o bem-estar emocional e mental dos pacientes. No estudo em questão, identificou-se associação do odor com o sentimento de vergonha e a impossibilidade do paciente em frequentar locais públicos, fatores ligados ao acometimento de isolamento social. </p>
				<p>Sob essa perspectiva, duas pesquisas de cunho fenomenológico apontaram o odor como principal sintoma que demanda dos pacientes diversas estratégias para escondê-lo. A sensação eminente de vazamento do odor, possibilidade de que outras pessoas podem senti-lo e o enojamento alheio desencadeiam problemas de ansiedade e vergonha que, consequentemente, limitam as atividades diárias. Além disso, a mão de obra intensiva demanda uma quantidade imensa de tempo de limpeza de curativo da ferida, sendo então, um dos fatores que contribuem para que algumas participantes evitem frequentar locais públicos, isolando-se no seu domicílio<xref ref-type="bibr" rid="B5"><sup>5</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B25"><sup>25</sup></xref>. </p>
				<p>Um estudo de meta-análise evidenciou que o isolamento social, solidão e viver sozinho corresponderam a uma média de 29%, 26% e 32% de aumento probabilidade de mortalidade, respectivamente. Os resultados também diferem entre a idade dos participantes, com déficits sociais sendo mais preditivos de morte em amostras com uma média de idade mais jovem que 65 anos. No geral, a influência do isolamento social no risco de mortalidade é comparável com os fatores de risco bem estabelecidos para a mortalidade <xref ref-type="bibr" rid="B26"><sup>26</sup></xref>. Sob essa ótica, sugere-se que o isolamento social promovido pelo odor pode influenciar no declínio da sobrevida dos pacientes com FTM.</p>
				<p>A complexidade das feridas crônicas na doença avançada requer avanço no pensamento crítico e científico para auxiliar a qualidade de vida dos pacientes. Métodos sistemáticos de avaliação multidisciplinar das experiências dos pacientes e dos problemas clínicos são necessários, juntamente com estratégias de gestão eficazes, embora reconhecendo seja altamente individual a apresentação de FTM <xref ref-type="bibr" rid="B2"><sup>2</sup></xref>. Em uma pesquisa realizada com 70 pacientes em Taiwan evidenciou pela análise de regressão múltipla que o odor, a dor e os problemas psicológicos foram estatisticamente significativos para o déficit da qualidade de vida e responsável por 87% da variância <xref ref-type="bibr" rid="B27"><sup>27</sup></xref>. Dessa forma, o constrangimento e a impossibilidade ao convívio social transmitido pelo odor são determinantes que afetam a qualidade de vida dos pacientes com essas afecções. </p>
				<p>Além disso, o mau cheiro é citado por pacientes e cuidadores como um dos aspectos mais angustiantes, que interfere a sociabilidade do portador. No entanto, o estudo constatou-se que não houve associação significativa entre o odor e comprometimento no relacionamento do paciente com os seus familiares e amigos. A ausência de uma abordagem padronizada para avaliação e gestão ressalta a necessidade de recolher dados de base para apoiar o desenvolvimento de diretrizes <xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B22"><sup>22</sup></xref> que incluem a integração familiar no cuidado a esses pacientes. </p>
				<p>Como demonstrado, os pacientes com feridas malcheirosas têm necessidades físicas e psicológicas complexas. As naturezas psicossocial e espiritual do paciente são aspectos pouco abordados pelos profissionais de saúde, e mesmo profissionais treinados em cuidados paliativos apresentam dificuldade de analisar, abordar e integrar as diferentes dimensões do ser humano, principalmente diante de situações de finitude <xref ref-type="bibr" rid="B15"><sup>15</sup></xref>. Em um estudo realizado com quatorze enfermeiras, foram descritas experimentações de raiva, frustração, inadequação, tristeza e culpa por não serem capazes de cuidar dos seus pacientes com FTM da maneira que consideravam ser adequada <xref ref-type="bibr" rid="B25"><sup>25</sup></xref>. Isso aponta para a necessidade de uma profunda reflexão acerca dessa temática, além de incluí-la nos contextos acadêmicos e de treinamento profissional.</p>
				<p>Para o controle desses sintomas, além de realização de curativos adequados a cada particularidade do paciente, é necessário o conhecimento de produtos que objetivam minimizar os sinais e sintomas presentes na lesão. Em relação ao odor, o produto com mais eficiência é o metronidazol <xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B24"><sup>24</sup></xref> responsável também pelo controle bacteriano. Além disso, a implantação de produtos que executem o debridamento autolítico por meio da utilização de agentes químicos, pode efetivamente suavizar e remover o tecido necrosado <xref ref-type="bibr" rid="B3"><sup>3</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B10"><sup>10</sup></xref>, principal responsável pela produção de odor(28). Estudos nacionais demonstraram que o Metronidazol gel é o mais indicado e efetivo no controle e manejo do odor em FTM <xref ref-type="bibr" rid="B1"><sup>1</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B9"><sup>9</sup></xref><sup>)(</sup><xref ref-type="bibr" rid="B29"><sup>29</sup></xref> . No estudo em questão, usou-se o Metronidazol gel 0,8% em todos os pacientes como meio de controle do odor. </p>
				<p>O registro de enfermagem neste âmbito é bastante incipiente, não havendo um instrumento adequadamente elaborado para as anotações sobre a ferida tumoral, que apresenta particularidades diferentes às demais lesões crônicas. Há sugestão de utilização de ferramentas para a avaliação da ferida e seus sinais e sintomas. Em prática, as opiniões subjetivas de pacientes e cuidadores são os melhores indicadores para orientar as ações de enfermagem <xref ref-type="bibr" rid="B10"><sup>10</sup></xref>. Sendo assim, é evidente a necessidade de elaboração de diretrizes e protocolos interdisciplinares que viabilizem um atendimento com mais qualidade e coesão nas intervenções destinada a cada paciente. </p>
				<p>O enfermeiro destaca-se enquanto agente de cuidados com o paciente com lesão, pois realiza diversos procedimentos técnicos, como a troca de curativo <xref ref-type="bibr" rid="B30"><sup>30</sup></xref>. Além disso, permanece por períodos de tempo com o paciente, seus cuidadores e/ou familiares. Esse cenário favorece a construção e fortalecimento de vínculo paciente-profissional de saúde, o que propicia a capacidade de detectar os anseios psicológicos utilizando-se das possibilidades existentes em seu processo de cuidado a fim manejá-los, promovendo conforto e qualidade de vida.</p>
				<p>Limitações do estudo</p>
				<p>Existiram limitações do estudo quanto ao tamanho da amostra, pois o cenário de pesquisa possui atendimento regionalizado, o que dificultou o recrutamento de pacientes de outras localidades. A ausência de escalas que avaliem a interferência do odor na dinâmica psicossocial de pacientes com essas lesões trouxe a necessidade da construção de uma escala inédita na área oncológica. Os resultados desta pesquisa possibilitarão a realização de outros estudos com o mesmo tema, uma vez que o tema explorado carece de estudos de investigação no âmbito nacional. </p>
				<p>Contribuições para a área de enfermagem</p>
				<p>O enfermeiro, como membro da equipe multidisciplinar, realiza procedimentos que transcendem o manuseio técnico. Considerar os anseios psicológicos e sociais no cuidado aos pacientes com FTM proporcionará uma visão holística, aumentando a efetividade da sistematização da assistência, cultivando, assim, a dignidade ao paciente oncológico. </p>
			</sec>
			<sec sec-type="conclusions">
				<title>CONCLUSÃO</title>
				<p>O odor é o sinal que pode favorecer, diretamente, o isolamento social em pacientes com FTM, sendo responsável por causar constrangimento e impedir que os clientes frequentem locais públicos. Tais fatores podem estar relacionados entre si, uma vez que o fato de apresentar constrangimento perante o mau cheiro pode impedir a socialização do paciente. Além disso, pode ser observado o agravamento da qualidade de vida com consequente deterioração do estado de saúde, uma vez que essa variável pode produzir ansiedade e depressão. </p>
				<p>O estudo piloto surge como sugestão de como se podem obter, quantitativamente, dados sobre possíveis associações de odor e fatores que podem contribuir para o isolamento social em pacientes com feridas tumorais, tanto por meio da construção da escala likert, como pela realização de procedimentos estatísticos para as relações das variáveis por meio de um estudo mais robusto. </p>
				<p>A enfermagem atua no manejo e controle de sinais e sintomas dos pacientes com FTM. Além do conhecimento sobre as idiossincrasias dessas lesões e dos produtos adequados ao seu cuidado, é fulcral que o profissional conheça a interferência psicossocial que os sinais e sintomas, sobretudo o odor, podem causar. Dessa forma, a equipe poderá atuar de maneira holística no cuidado ao paciente, enxergando, além dos sintomas, seus anseios psicológicos e sociais. </p>
			</sec>
		</body>
		<back>
			<ack>
				<title>Fomento</title>
				<p>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Bolsa de mestrado: 2014-2015; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ): bolsa de fomento de pesquisa. Edital PIBIC/ CNPQ/ UFF 2015-2016.</p>
			</ack>
		</back>
	</sub-article>
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</article>
