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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">estpsi</journal-id>
            <journal-title-group>
                <journal-title>Estudos de Psicologia (Campinas)</journal-title>
                <abbrev-journal-title abbrev-type="publisher">Estud. psicol.</abbrev-journal-title>
            </journal-title-group>
            <issn pub-type="ppub">0103-166X</issn>
            <issn pub-type="epub">1982-0275</issn>
            <publisher>
                <publisher-name>Programa de Pós-Graduação em Psicologia, Pontifícia Universidade Católica de Campinas</publisher-name>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">00006</article-id>
            <article-id pub-id-type="doi">10.1590/1982-02752018000400006</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>HEALTH PSYCHOLOGY</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Motivation and adherence to psychosocial treatment for alcohol and drug use-related problems</article-title>
                <trans-title-group xml:lang="pt">
                    <trans-title>Motivação e adesão ao tratamento psicossocial entre usuários de substâncias químicas</trans-title>
                </trans-title-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <contrib-id contrib-id-type="orcid">0000-0001-6310-5828</contrib-id>
                    <name>
                        <surname>LEITE</surname>
                        <given-names>Jose Carlos de Carvalho</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01">1</xref>
                    <xref ref-type="corresp" rid="c01"/>
                </contrib>
                <contrib contrib-type="author">
                    <contrib-id contrib-id-type="orcid">0000-0002-5001-9776</contrib-id>
                    <name>
                        <surname>LUZ</surname>
                        <given-names>Maria Fernanda Duarte da</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff02">2</xref>
                </contrib>
                <contrib contrib-type="author">
                    <contrib-id contrib-id-type="orcid">0000-0001-9576-2443</contrib-id>
                    <name>
                        <surname>WALZ</surname>
                        <given-names>Júlio Cézar</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01_2">1</xref>
                </contrib>
                <contrib contrib-type="author">
                    <contrib-id contrib-id-type="orcid">0000-0003-2043-6162</contrib-id>
                    <name>
                        <surname>FILIPPIN</surname>
                        <given-names>Lidiane Isabel</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01_3">1</xref>
                </contrib>
                <contrib contrib-type="author">
                    <contrib-id contrib-id-type="orcid">0000-0002-5038-7341</contrib-id>
                    <name>
                        <surname>SALDANHA</surname>
                        <given-names>Ricardo Pedrozo</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff01_4">1</xref>
                </contrib>
                <contrib contrib-type="author">
                    <contrib-id contrib-id-type="orcid">0000-0002-7055-8881</contrib-id>
                    <name>
                        <surname>DRACHLER</surname>
                        <given-names>Maria de Lourdes</given-names>
                    </name>
                    <xref ref-type="aff" rid="aff03">3</xref>
                </contrib>
            </contrib-group>
            <aff id="aff01">
                <label>1</label>
                <institution content-type="orgname">Universidade La Salle</institution>
                <institution content-type="orgdiv1">Programa de Pós-Graduação em Saúde e Desenvolvimento Humano</institution>
                <email>jcdc.leite@gmail.com</email>
                <addr-line>
                    <named-content content-type="city">Canoas</named-content>
                    <named-content content-type="state">RS</named-content>
                </addr-line>
                <country country="BR">Brasil</country>
                <institution content-type="original">Universidade La Salle, Programa de Pós-Graduação em Saúde e Desenvolvimento Humano. Av. Victor Barreto, 2288, 92010-000, Canoas, RS, Brasil.</institution>
            </aff>
            <aff id="aff01_2">
                <label>1</label>
                <institution content-type="orgname">Universidade La Salle</institution>
                <institution content-type="orgdiv1">Programa de Pós-Graduação em Saúde e Desenvolvimento Humano</institution>
                <addr-line>
                    <named-content content-type="city">Canoas</named-content>
                    <named-content content-type="state">RS</named-content>
                </addr-line>
                <country country="BR">Brasil</country>
                <institution content-type="original">Universidade La Salle, Programa de Pós-Graduação em Saúde e Desenvolvimento Humano. Av. Victor Barreto, 2288, 92010-000, Canoas, RS, Brasil.</institution>
            </aff>
            <aff id="aff01_3">
                <label>1</label>
                <institution content-type="orgname">Universidade La Salle</institution>
                <institution content-type="orgdiv1">Programa de Pós-Graduação em Saúde e Desenvolvimento Humano</institution>
                <addr-line>
                    <named-content content-type="city">Canoas</named-content>
                    <named-content content-type="state">RS</named-content>
                </addr-line>
                <country country="BR">Brasil</country>
                <institution content-type="original">Universidade La Salle, Programa de Pós-Graduação em Saúde e Desenvolvimento Humano. Av. Victor Barreto, 2288, 92010-000, Canoas, RS, Brasil.</institution>
            </aff>
            <aff id="aff01_4">
                <label>1</label>
                <institution content-type="orgname">Universidade La Salle</institution>
                <institution content-type="orgdiv1">Programa de Pós-Graduação em Saúde e Desenvolvimento Humano</institution>
                <addr-line>
                    <named-content content-type="city">Canoas</named-content>
                    <named-content content-type="state">RS</named-content>
                </addr-line>
                <country country="BR">Brasil</country>
                <institution content-type="original">Universidade La Salle, Programa de Pós-Graduação em Saúde e Desenvolvimento Humano. Av. Victor Barreto, 2288, 92010-000, Canoas, RS, Brasil.</institution>
            </aff>
            <aff id="aff02">
                <label>2</label>
                <institution content-type="orgname">Clínica Psiquiátrica Santa Tecla</institution>
                <addr-line>
                    <named-content content-type="city">Canoas</named-content>
                    <named-content content-type="state">RS</named-content>
                </addr-line>
                <country country="BR">Brasil</country>
                <institution content-type="original">Clínica Psiquiátrica Santa Tecla. Canoas, RS, Brasil.</institution>
            </aff>
            <aff id="aff03">
                <label>3</label>
                <institution content-type="orgname">Governo do Estado do Rio Grande do
                    Sul</institution>
                <institution content-type="orgdiv1">Secretaria Estadual da Saúde</institution>
                <addr-line>
                    <named-content content-type="city">Porto Alegre</named-content>
                    <named-content content-type="state">RS</named-content>
                </addr-line>
                <country country="BR">Brasil</country>
                <institution content-type="original">Governo do Estado do Rio Grande do Sul, Secretaria Estadual da Saúde. Porto Alegre, RS, Brasil.</institution>
            </aff>
            <author-notes>
                <corresp id="c01">Correspondência para/Correspondence to: J.C.C. LEITE. E-mail: &lt;<email>jcdc.leite@gmail.com</email>&gt;.</corresp>
            </author-notes>
            <pub-date pub-type="epub-ppub">
                <season>Oct-Dec</season>
                <year>2018</year>
            </pub-date>
            <volume>35</volume>
            <issue>4</issue>
            <fpage>389</fpage>
            <lpage>398</lpage>
            <history>
                <date date-type="received">
                    <day>02</day>
                    <month>06</month>
                    <year>2016</year>
                </date>
                <date date-type="rev-recd">
                    <day>20</day>
                    <month>07</month>
                    <year>2017</year>
                </date>
                <date date-type="accepted">
                    <day>04</day>
                    <month>08</month>
                    <year>2017</year>
                </date>
            </history>
            <permissions>
                <license license-type="open-access"
                    xlink:href="http://creativecommons.org/licenses/by/4.0/" xml:lang="en">
                    <license-p>This is an Open Access article distributed under the terms of the
                        Creative Commons Attribution License, which permits unrestricted use,
                        distribution, and reproduction in any medium, provided the original work is
                        properly cited.</license-p>
                </license>
            </permissions>
            <abstract>
                <title>Abstract</title>
                <p>This is a prospective cohort study of 150 individuals attending a specialized health service for substance-related disorders. The study investigated the association between motivation to remain in treatment and treatment adherence. All service users were interviewed soon after admission to the treatment program and were followed-up during the first two months of treatment. A Cox Regression Model was used to estimate the hazard ratios for dropout during the two months following the admission interview. The results indicated that individuals with a primary-school education, lack of income, and low motivation toward treatment at the admission interview presented a higher risk of treatment dropout. This study showed the importance of motivation in changing addictive behavior and in adherence to treatment as essential factors for recovery.</p>
            </abstract>
            <trans-abstract xml:lang="pt">
                <title>Resumo</title>
                <p>A associação entre a motivação para manter-se em tratamento e a respectiva adesão foi estudada em uma coorte prospectiva de 150 usuários de um Centro de Atenção Psicossocial-Álcool e Drogas. Modelo de Regressão de Cox foi usado para estimar as razões de risco para o abandono do tratamento durante os dois primeiros meses após a entrevista de admissão. Os resultados sugerem que a pouca escolaridade (até a 9ª série), a ausência ou insuficiência de renda, bem como a baixa motivação no momento da entrevista de admissão são fatores de risco para o abandono do tratamento. As motivações para mudar o comportamento aditivo e para aderir ao tratamento foram identificadas como um dos fatores importantes para a recuperação de indivíduos com problemas relacionados ao uso de substâncias químicas.</p>
            </trans-abstract>
            <kwd-group xml:lang="en">
                <title>Keywords</title>
                <kwd>Motivation</kwd>
                <kwd>Substance-related disorders</kwd>
                <kwd>Treatment outcome</kwd>
            </kwd-group>
            <kwd-group xml:lang="pt">
                <title>Palavras-chave</title>
                <kwd>Motivação</kwd>
                <kwd>Transtornos relacionados ao uso de substâncias</kwd>
                <kwd>Resultado do tratamento</kwd>
            </kwd-group>
            <counts>
                <fig-count count="0"/>
                <table-count count="3"/>
                <equation-count count="0"/>
                <ref-count count="27"/>
                <page-count count="10"/>
            </counts>
        </article-meta>
    </front>
    <body>
        <p>The World Health Organization (WHO) considers the abusive use of psychoactive substances
            to be a chronic and recurrent disease causing worldwide concern. Abuse is likely when
            individuals have difficulties dealing with stress in everyday contexts, and is often
            associated with domestic violence, particularly against women (<xref ref-type="bibr"
                rid="B10">Mangueira, Guimarães, Mangueira, Fernandes, &amp; Lopes, 2015</xref>).
            Because alcohol is a licit drug used in family celebrations, meetings with friends, and
            even religious rituals, it has become the most commonly used drug. In Brazil, 68.7% of
            the adult population have used alcohol at some point in their lives and 11.2% are
            alcoholics; furthermore, the prevalence of the use of other drugs in this age group is
            0.5% for opiates, 0.7% for cocaine, 2.6% for marijuana, 0.7% for amphetamines, and 0.2%
            for ecstasy (<xref ref-type="bibr" rid="B15">Peixoto et al., 2010</xref>). Therefore,
            the increase in the use of psychoactive substances has challenged public health
            policies, causing the Brazilian Ministry of Health to increasingly invest in
            implementing <italic>Centros de Atenção Psicossocial-Álcool e Drogas</italic> (CAPS-AD,
            Psychosocial Care Centers-Alcohol and Drugs).</p>
        <p>By decision of the Ministry of Health, CAPS-AD have been implemented in cities with more
            than 100,000 inhabitants and employ a multidisciplinary team (including a physician,
            nurse, psychologist, and social worker, as well as nursing technicians and
            administrative assistants). In these services, first, the patient is welcomed, which is
            an opportunity to assess physical and psychosocial vulnerabilities. The next step is to
            develop interventions based on therapeutic plans according to the severity of substance
            use-related problems: intensive, semi-intensive, and non-intensive. In intensive plans,
            patients receive daily care; in semi-intensive plans, because patients show less
            suffering than those in intensive plans, they receive care three times a week; and, in
            non-intensive plans, care is provided up to three times a month. Hospitalization for
            detoxification, accompanied by motivational intervention to promote subsequent adherence
            to psychosocial treatment, is offered to people with chemical dependence and who pose a
            risk to their own lives and those of others. Therefore, people with psychoactive
            substance use-related problems and their relatives are guaranteed access by Brazilian
            Law to care towards resocialization and the reestablishment of social ties (<xref
                ref-type="bibr" rid="B16">Pitta, Coutinho, &amp; Rocha, 2015</xref>). Despite
            opportunities to access this type of healthcare, the rate of treatment dropout before
            completion remains high. For example, after the admission interview and during the first
            two months, up to 73% of CAPS-AD users discontinue treatment (<xref ref-type="bibr"
                rid="B09">Leite, Seminotti, Freitas, &amp; Drachler, 2011</xref>), which presents a
            continuing challenge for healthcare professionals to keep users motivated to comply with
            their therapeutic plan.</p>
        <p>Motivational variables have been considered robust predictors of human action in healthy
            and diseased populations (<xref ref-type="bibr" rid="B02">Bandura, 1997</xref>; <xref
                ref-type="bibr" rid="B04">Deci &amp; Ryan, 2008</xref>). Because these variables are
            modifiable and based on theories (for example, self-efficacy and self-determination
            theories), they must be assessed when initiating and maintaining health promotion
            behaviors (<xref ref-type="bibr" rid="B01">Amorim, Ramos, Bento, &amp; Gazzinelli,
                2013;</xref>
            <xref ref-type="bibr" rid="B27">Zemore &amp; Ajzen, 2014</xref>; <xref ref-type="bibr"
                rid="B21">Schroder, Sellman, Frampton, &amp; Deering, 2009</xref>). Studies suggest
            that the expectations of patients regarding their recovery process play a key role in
            the treatment course. These expectations are understood as indications of their personal
            capacity to perform the necessary actions to reach a proposed goal in a specified time
                (<xref ref-type="bibr" rid="B02">Bandura, 1997</xref>), for example, the
            self-efficacy expectation of continuing treatment for alcohol and drug use-related
            problems and the expectation of abstinence or control of addictive behavior (<xref
                ref-type="bibr" rid="B09">Leite et al., 2011</xref>).</p>
        <p>Self-efficacy expectations of performing a desired behavior are key indicators of the
            motivation for such behavior. These expectations are beliefs (convictions) that one is
            able to perform behaviors necessary to achieve specific goals (<xref ref-type="bibr"
                rid="B02">Bandura, 1997</xref>). Accordingly, the self-efficacy expectation of
            treatment adherence refers to the prediction of personal capacity to complete the
            therapeutic plan in difficult situations, such as when patients feel that they are not
            reaching their therapeutic goals or when the sessions are too stressful. Conversely, if
            the treatment in question is abstinence or control of alcohol or drug use, the
            self-efficacy expectation will be the prediction of personal ability to perform such
            behavior in situations of risk (including being in the presence of friends while they
            use alcohol or other drugs). Empirical studies assessing the effectiveness of treatments
            for chemical dependence have shown evidence of an association between monitoring
            self-efficacy expectations of treatment adherence and improved therapeutic response in
            motivational interventions (<xref ref-type="bibr" rid="B03">D&#x2019;Amico et al.,
                2015</xref>; <xref ref-type="bibr" rid="B13">Miller &amp; Rollnick, 2012</xref>).
            Therefore, tailoring treatment to user needs and expectations remains a challenge in
            assessing the effectiveness of these programs (<xref ref-type="bibr" rid="B14">Miller
                &amp; Moyers, 2015</xref>).</p>
        <p>Self-efficacy theory (<xref ref-type="bibr" rid="B02">Bandura, 1997</xref>) hypothesizes
            that the beliefs of individuals regarding their capacity to perform specific activities
            successfully are a key motivating element in performing such activities. Thus, their
            beliefs in their skills to overcome obstacles (including situations that present risks
            for relapse) may influence their commitment to perform specific activities (including
            adherence to treatment for chemical dependence) and their ability to enjoy the
            advantages of a healthier life (for example, a life free of substance use-related
            problems). The present study deepens knowledge on the role of motivation in therapeutic
            plan completion among adults with chemical dependence-related problems. Specifically,
            this study examines possible associations between adherence to the therapeutic plan,
            considering the effects of expectations of social support outside the clinical setting,
            changing addictive behaviors, and remaining in treatment.</p>
        <sec sec-type="methods">
            <title>Method</title>
            <sec>
                <title>Study Participants and Design</title>
                <p>Adult (18 years and older) users of a CAPS-AD participated in this prospective
                    cohort study. The CAPS-AD is located in the largest metropolitan region of
                    Southern Brazil and provides services, in agreement with the municipal
                    government, to offer treatment to patients within the <italic>Sistema Único de
                        Saúde</italic> (SUS, Unified Health System). Initially, the sample size was
                    calculated as 120 individuals, considering an estimated drop-out rate ranging
                    from 30.0 to 50.0% (<xref ref-type="bibr" rid="B11">Micheletti, Kritski, &amp;
                        Braga, 2016</xref>) in the first six months of treatment, with a 95.0%
                    confidence level, 80.0% power, and 1.7% estimated risk for dichotomous risk
                    factors. Moreover, the initial sample was increased by 25.0% to allow for a
                    possible lack of information in the records. Individuals in the sample
                    systematically used alcohol, with different severities of dependence. The
                    CAPS-AD professionals and the users participating in the study considered that
                    overcoming the problems related to substance use was the main objective of
                    treatment.</p>
            </sec>
            <sec>
                <title>Data Collection</title>
                <p>All users initiating outpatient psychosocial treatment at the CAPS-AD were
                    followed up during the first two months of treatment. Participants were invited
                    to the study by CAPS-AD staff members until the estimated sample size was
                    reached. Program users who accepted the invitation were contacted by a trained
                    interviewer and answered questions on exposure variables, after signing the
                    informed consent form provided by the interviewer, during the first week after
                    admission to treatment. The interview was conducted in the period shortly after
                    admission to enable participants to adjust their expectations regarding the way
                    the health service works. Two months after the first interview, a second data
                    collection was performed to measure the outcomes (dependent variables).</p>
            </sec>
            <sec>
                <title>Measurements</title>
                <sec>
                    <title>Dependent variables or outcomes</title>
                    <p>Undergoing treatment (yes or no) at the end of the 2nd month after admission
                        and total participation time were the clinical outcomes for the purposes of
                        the present study. These data were collected from medical records. The
                        allocation of participants to one of the categories of exposure variables
                        and treatment time were operationally defined according to the criteria of
                        the CAPS-AD involved in the study. The CAPS-ADs define treatment dropout as
                        user absence from any therapeutic activity of the program for 30 consecutive
                        days.</p>
                </sec>
                <sec>
                    <title>Exposure variables of interest</title>
                    <p>The exposure variables of interest were measured using standardized scales
                        administered to patients by trained interviewers within a week after the
                        admission interview. The following exposure variables were assessed:
                        expectations of social support outside the clinical setting, self-efficacy
                        expectation of changing addictive behaviors, self-efficacy expectation of
                        treatment adherence, and severity of dependence.</p>
                    <p>&#x201C;Expectations of social support outside the clinical setting&#x201D;
                        was measured using a 19-item scale, the <italic>Escala de Apoio
                            Social</italic> (EAS), which assesses the likelihood of patients
                        receiving different types of support from relatives, friends, or significant
                        others. The original version of this scale, the Medical Outcomes
                        Study&#x2019;s Social Support Scale (MOS), developed by <xref
                            ref-type="bibr" rid="B22">Sherbourne and Stewart (1991)</xref>, was
                        validated for Brazil by <xref ref-type="bibr" rid="B08">Griep, Chor,
                            Faerstein, Werneck, and Lopes (2005)</xref>. The items are grouped into
                        five subscales measuring material, affective, emotional, informational, and
                        positive social interaction support. The validation of the Brazilian EAS
                        scale included factor analysis and reliability assessment (Cronbach&#x2019;s
                        alpha coefficients). The factorial structure corresponding to the subscales
                        explained 72% of the variance. Cronbach&#x2019;s alpha coefficients were
                        equal to or higher than 0.83 for all factors and the item-total scale score
                        correlations ranged from 0.71 to 0.84. In the present study,
                        &#x201C;high&#x201D; or &#x201C;low&#x201D; social support (cut-off point
                        established by the median of the total scale score distribution) was
                        considered to examine the possible relationship between this score and the
                        outcomes.</p>
                    <p>&#x201C;Self-efficacy expectations of changing addictive behaviors&#x201D;
                        were measured using the <italic>Escala de Autoeficácia para Abstinência de
                            Drogas</italic> (EAAD). The original version of the Alcohol Abstinence
                        Self-Efficacy Scale (AASE) (<xref ref-type="bibr" rid="B05">DiClemente,
                            Carbonari, Montgomery, &amp; Hughes, 1994</xref>) was validated for use
                        in Brazil by <xref ref-type="bibr" rid="B07">Freire (2009)</xref>. The
                        Brazilian version includes 24 items distributed in four subscales assessing
                        the confidence in an individual&#x2019;s ability to refrain from using a
                        chemical in the risk situations described. The first subscale, negative
                        affect, includes items measuring negative intrapersonal and interpersonal
                        evaluations. The second subscale, positive social interactions, consists of
                        items representing social situations in which substance use aims to
                        facilitate interpersonal relationships. The third subscale, concerns with
                        oneself and others, consists of items representing physical discomfort or
                        pain, worries about other people, and cravings for substances. The fourth
                        subscale, abstinence/impulse, represents the willpower to change addictive
                        behaviors. In the validation of the EAAD in a Brazilian sample, the
                        factorial structure corresponding to the four subscales explained 54% of the
                        variance. Cronbach&#x2019;s alpha coefficients ranged from 0.72 to 0.92
                        (0.86 for negative affect, 0.82 for positive social interactions, 0.72 for
                        concerns, 0.74 for abstinence/impulse, and 0.92 for total EAAD scores).
                        Considering that the participants in the present study could have concurrent
                        alcohol and drug use-related problems, the questionnaire on self-efficacy
                        expectations of changing addictive behaviors (originally designed for
                        alcohol use) was adapted to circumstances of chemical substance use.</p>
                    <p>&#x201C;Self-efficacy expectations of remaining in treatment&#x201D; were
                        measured by a single question formulated specifically for the present study.
                        The participants were asked to indicate the level of certainty that they
                        would be able to remain in treatment, participating in all activities, for
                        at least the next two months. The answers were organized into five
                        categories: I will certainly not be able to participate (-2), I think I will
                        not participate (-1), I do not know (0), I think I will participate (+1),
                        and I will certainly be able to participate (+2).</p>
                    <p>&#x201C;Severity of alcohol dependence&#x201D; was measured using the Short
                        Alcohol Dependence Data (SADD) scale (<xref ref-type="bibr" rid="B18"
                            >Raistrick, Dunbar, &amp; Davidson, 1983</xref>), validated for use in
                        Brazil by <xref ref-type="bibr" rid="B19">Rosa-Oliveira et al.
                        (2011)</xref>. The scale includes 15 self-administered items assessing
                        alcohol consumption. The degree of dependence is estimated into three
                        categories, considering the total scale score: 1 to 9 = mild dependence, 10
                        to 19 = moderate dependence, and higher than 20 = serious dependence. In the
                        SADD validation in a Brazilian sample, the principal components analysis of
                        the scale explained 69.6% of data variability; Cronbach&#x2019;s alpha
                        coefficient was 0.79, suggesting that the items of the scale converge to the
                        same construct (alcohol dependence).</p>
                </sec>
            </sec>
            <sec>
                <title>Other exposure variables</title>
                <p>The following data were measured by close-ended questions: (a) patients&#x2019;
                    social and economic conditions, including age, gender, education, income,
                    occupation, housing, and living situation (alone or with others); (b)
                    experiences of previous treatment for chemical substance use-related problems;
                    and (c) psychoactive drugs used.</p>
            </sec>
            <sec>
                <title>Statistical Analysis</title>
                <p>The objective of the analysis was to investigate the association between
                    motivation to remain in psychosocial treatment at a CAPS-AD and remaining in
                    treatment two months after the admission interview, which is the outcome of
                    interest of this study. The duration of treatment participation and the outcome
                    predictors were investigated by survival analysis, using the Cox regression
                    model. The duration of treatment participation for participants who remained in
                    treatment for at least two months was censored (interrupted) at the end of the
                    second month, when their follow up by the research study ended.</p>
                <p>Hazard ratios of the occurrence of treatment dropout, at each time point in the
                    first two months of treatment, were estimated using univariate (or unadjusted)
                    and multivariate (or adjusted) Cox Regression Models. Each univariate model
                    included the outcome of interest and an exposure variable; each multivariate Cox
                    Regression Model included the exposure variables that showed evidence of effect
                    on the outcome of interest (treatment dropout). A significance level of 5% was
                    determined as indicating evidence of the effect of exposure variables of
                    interest on the hazard ratio of treatment dropout in the study period. The
                    Statistical Package for the Social Sciences (IBM SPSS Inc., Chicago, IL, EUA)
                    software version 22 was used for data analysis.</p>
            </sec>
            <sec>
                <title>Ethical Considerations</title>
                <p>The Research Ethics Committee of University La Salle authorized and monitored the
                    ethical aspects of the study (Opinion n&#xBA; 663.211 of 05/26/2014 &#x2013;
                    CAAE 26300613.0.0000.5307). The participants were only included in the study
                    after signing the informed consent form and were free to withdraw from the
                    study, at any time, without affecting their treatment.</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <p>A total of 150 patients beginning psychosocial treatment for chemical substance
                use-related problems participated in the study. The second column of <xref
                    ref-type="table" rid="t01">Table 1</xref> outlines the distribution of patients
                according to their social and economic characteristics, previous psychosocial
                treatments, severity of alcohol dependence at the beginning of treatment, and use of
                illicit drugs in the previous 30 days. Most participants were men (87.3%;
                    <italic>n</italic> = 131/150) and 12.7% were women (<italic>n</italic> =
                19/150). Their age ranged from 19 to 68 years, including 34.7% (<italic>n</italic> =
                52/150) of participants who were 19 to 30 years old, 40.6% (<italic>n</italic> =
                61/150) from 31 to 40 years old, and 24.7% (<italic>n</italic> = 37/150) from 40 to
                68 years old. Most participants (55.4%; <italic>n</italic> = 83/150) had only a
                primary school education, 35.3% (<italic>n</italic> = 53/150) had a secondary
                education, and 9.3% (<italic>n</italic> = 14/150) had attended college. The majority
                (73.3%; <italic>n</italic> = 110/150) of participants had no source of income.
                Social support outside the clinical environment was considered high (higher than the
                median) for 50.7% (<italic>n</italic> = 76/150) of participants. Approximately half
                (47.3%; <italic>n</italic> = 71/150) lived alone, whereas the remaining 52.7% of
                participants lived with other people. Most participants (64.7%; <italic>n</italic> =
                7/150) had previously taken part in some type of treatment for alcohol or drug
                use-related problems; the rest (35.3; <italic>n</italic> = 53/150) were starting
                treatment for those problems for the first time. Nearly all patients (98.0%;
                    <italic>n</italic> = 147/150) had severe alcohol dependence at the beginning of
                treatment, whereas the other 2.0% (<italic>n</italic> = 3), had mild or moderate
                dependence. Most patients (89.3%; <italic>n</italic> = 134/150) reported the use of
                illicit drugs in the last month.</p>
            <table-wrap id="t01">
                <label>Table 1</label>
                <caption>
                    <title>Characteristics of patients who discontinued treatment</title>
                </caption>
            <graphic xlink:href="tb1-gt1.png"/>
                <table frame="hsides" rules="groups">
                    <tbody>
                        <tr>
                            <td rowspan="2">Variables</td>
                            <td colspan="2" style="border-bottom-width:thin;border-bottom-style:solid">Participants</td>
                            <td>&nbsp;</td>
                            <td colspan="2" style="border-bottom-width:thin;border-bottom-style:solid">Discontinuation</td>
                            <td rowspan="2"><italic>p</italic></td>
                        </tr>
                        <tr>
                            <td>n</td>
                            <td>%</td>
                            <td>&nbsp;</td>
                            <td>n</td>
                            <td>%</td>
                        </tr>
                        <tr>
                            <td><italic>Gender</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.454<xref ref-type="table-fn" rid="TFN01">a</xref></td>
                        </tr>
                        <tr>
                            <td>Male</td>
                            <td>131</td>
                            <td>087.3</td>
                            <td>&nbsp;</td>
                            <td>117</td>
                            <td>89.3</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Female</td>
                            <td>19</td>
                            <td>012.7</td>
                            <td>&nbsp;</td>
                            <td>16</td>
                            <td>84.2</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Age (years)</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.301<xref ref-type="table-fn" rid="TFN02">b</xref></td>
                        </tr>
                        <tr>
                            <td>1930</td>
                            <td>52</td>
                            <td>034.7</td>
                            <td>&nbsp;</td>
                            <td>44</td>
                            <td>84.6</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>31&#x2013;40</td>
                            <td>61</td>
                            <td>040.6</td>
                            <td>&nbsp;</td>
                            <td>57</td>
                            <td>93.4</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>41&#x2013;68</td>
                            <td>37</td>
                            <td>024.7</td>
                            <td>&nbsp;</td>
                            <td>32</td>
                            <td>86.5</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Education level</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.001<xref ref-type="table-fn" rid="TFN02">b</xref></td>
                        </tr>
                        <tr>
                            <td>Up to primary</td>
                            <td>83</td>
                            <td>055.4</td>
                            <td>&nbsp;</td>
                            <td>80</td>
                            <td>96.4</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Secondary</td>
                            <td>53</td>
                            <td>035.3</td>
                            <td>&nbsp;</td>
                            <td>43</td>
                            <td>81.1</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Higher</td>
                            <td>14</td>
                            <td>009.3</td>
                            <td>&nbsp;</td>
                            <td>10</td>
                            <td>71.4</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Source of income</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.009<xref ref-type="table-fn" rid="TFN02">b</xref></td>
                        </tr>
                        <tr>
                            <td>Yes</td>
                            <td>40</td>
                            <td>026.7</td>
                            <td>&nbsp;</td>
                            <td>31</td>
                            <td>77.5</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>No</td>
                            <td>110</td>
                            <td>073.3</td>
                            <td>&nbsp;</td>
                            <td>102</td>
                            <td>92.7</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Social support outside the clinical setting</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.475<xref ref-type="table-fn" rid="TFN02">b</xref></td>
                        </tr>
                        <tr>
                            <td>High<xref ref-type="table-fn" rid="TFN03">c</xref></td>
                            <td>76</td>
                            <td>050.7</td>
                            <td>&nbsp;</td>
                            <td>66</td>
                            <td>86.8</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Low<xref ref-type="table-fn" rid="TFN04">d</xref></td>
                            <td>74</td>
                            <td>049.3</td>
                            <td>&nbsp;</td>
                            <td>67</td>
                            <td>90.5</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Living situation</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.580<xref ref-type="table-fn" rid="TFN02">b</xref></td>
                        </tr>
                        <tr>
                            <td>Alone</td>
                            <td>71</td>
                            <td>047.3</td>
                            <td>&nbsp;</td>
                            <td>64</td>
                            <td>90.1</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>With other people</td>
                            <td>79</td>
                            <td>052.7</td>
                            <td>&nbsp;</td>
                            <td>69</td>
                            <td>87.3</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Previous treatment</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.297<xref ref-type="table-fn" rid="TFN02">b</xref></td>
                        </tr>
                        <tr>
                            <td>No</td>
                            <td>53</td>
                            <td>035.3</td>
                            <td>&nbsp;</td>
                            <td>45</td>
                            <td>84.9</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Yes</td>
                            <td>97</td>
                            <td>064.7</td>
                            <td>&nbsp;</td>
                            <td>88</td>
                            <td>90.7</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Severity of alcohol dependence</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.305<xref ref-type="table-fn" rid="TFN01">a</xref></td>
                        </tr>
                        <tr>
                            <td>Mild to moderate</td>
                            <td>3</td>
                            <td>002.0</td>
                            <td>&nbsp;</td>
                            <td>2</td>
                            <td>66.7</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Severe</td>
                            <td>147</td>
                            <td>098.0</td>
                            <td>&nbsp;</td>
                            <td>131</td>
                            <td>89.1</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td><italic>Illicit drug use (last month)</italic></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                            <td>&lt;0.696<xref ref-type="table-fn" rid="TFN01">a</xref></td>
                        </tr>
                        <tr>
                            <td>No</td>
                            <td>16</td>
                            <td>010.7</td>
                            <td>&nbsp;</td>
                            <td>15</td>
                            <td>93.8</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr style="border-bottom-width:thin;border-bottom-style:solid">
                            <td>Yes</td>
                            <td>134</td>
                            <td>089.3</td>
                            <td>&nbsp;</td>
                            <td>118</td>
                            <td>88.1</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Total</td>
                            <td>150</td>
                            <td>100.0</td>
                            <td>&nbsp;</td>
                            <td>133</td>
                            <td>86.7</td>
                            <td>&nbsp;</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn>
                        <p>Note:</p>
                    </fn>
                    <fn id="TFN01">
                        <label>a</label>
                        <p>Fisher&#x2019;s exact test;</p>
                    </fn>
                    <fn id="TFN02">
                        <label>b</label>
                        <p>Pearson&#x2019;s chi-squared test;</p>
                    </fn>
                    <fn id="TFN03">
                        <label>c</label>
                        <p>High &#x2265; median;</p>
                    </fn>
                    <fn id="TFN04">
                        <label>d</label>
                        <p>Low &lt; median.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
            <p>Most patients (88.7%; <italic>n</italic> = 133/150) dropped out of the current
                psychosocial treatment at the CAPS-AD during the first two months of treatment. The
                third column of <xref ref-type="table" rid="t01">Table 1</xref> outlines the number
                and percentage of participants who dropped out of treatment, according to the
                exposure variables. The dropout rate decreased with education (chi-squared for
                linear trend, <italic>p</italic> &lt; 0.001) from 96.4% (<italic>n</italic> = 80/83)
                for primary education, to 71.4% (<italic>n</italic> = 10/14) for patients with
                higher education. Having some source of income was also associated with a lower
                treatment dropout rate (chi-squared, <italic>p</italic> = 0.009); 77.5%
                    (<italic>n</italic> = 31/40) of patients reporting some income dropped out,
                compared to 92.7% (<italic>n</italic> = 102/133) of those with no source of income.
                No evidence was found for associations between the psychosocial treatment dropout
                rate and the following variables: gender (chi-squared, <italic>p</italic> = 0.454),
                age group (<italic>p</italic> = 0.301), living alone or with other people
                    (<italic>p</italic> = 0.589), social support outside the clinical setting
                (chi-squared, <italic>p</italic> = 0.475), participation in previous treatment for
                alcohol or drug-related problems (<italic>p</italic> = 0.297), severity of alcohol
                dependence (<italic>p</italic> = 0.305), and illicit drug use in the last month
                    (<italic>p</italic> = 0.696).</p>
            <p>At the beginning of treatment, the score for self-efficacy expectations of changing
                addictive behaviors ranged from 11 to 100, and the score for self-efficacy
                expectations of remaining in treatment in the first two months ranged from 1 to 5.
                    <xref ref-type="table" rid="t02">Table 2</xref> shows that the self-efficacy
                expectations of changing addictive behaviors averaged 63.60 for patients who
                remained in treatment and 39.96 for those who dropped out in the first two months of
                treatment. Conversely, the self-efficacy expectations of remaining in treatment
                averaged 4.82 for the group of patients who remained in treatment, and 3.56 for
                those who dropped out of treatment in that period.</p>
            <table-wrap id="t02">
                <label>Table 2</label>
                <caption>
                    <title>Self-efficacy expectations at treatment onset according to treatment
                        adherence in the first two months</title>
                </caption>
            <graphic xlink:href="tb2-gt2.png"/>
                <table frame="hsides" rules="groups">
                    <tbody>
                        <tr>
                            <td rowspan="2"/>
                            <td rowspan="2">Participants (n)</td>
                            <td colspan="2"
                                style="border-bottom-width:thin;border-bottom-style:solid"
                                >Self-efficacy</td>
                        </tr>
                        <tr>
                            <td>Mean</td>
                            <td><italic>SD</italic></td>
                        </tr>
                        <tr>
                            <td><italic>Self-efficacy expectations of changing addictive
                                    behaviors</italic><xref ref-type="table-fn" rid="TFN05"
                                >1</xref></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Treatment adherence</td>
                            <td>17</td>
                            <td>63.60</td>
                            <td>22.19</td>
                        </tr>
                        <tr>
                            <td style="border-bottom-width:thin;border-bottom-style:solid">Treatment
                                dropout</td>
                            <td>133</td>
                            <td>39.96</td>
                            <td>22.40</td>
                        </tr>
                        <tr>
                            <td style="border-bottom-width:thin;border-bottom-style:solid"
                                >Total</td>
                            <td>150</td>
                            <td>42.64</td>
                            <td>23.53</td>
                        </tr>
                        <tr>
                            <td><italic>Self-efficacy expectations of treatment
                                    adherence</italic><xref ref-type="table-fn" rid="TFN06"
                                >2</xref></td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>Treatment adherence</td>
                            <td>17</td>
                            <td>04.82</td>
                            <td>00.53</td>
                        </tr>
                        <tr>
                            <td style="border-bottom-width:thin;border-bottom-style:solid">Treatment
                                dropout</td>
                            <td>133</td>
                            <td>03.56</td>
                            <td>01.81</td>
                        </tr>
                        <tr>
                            <td>Total</td>
                            <td>150</td>
                            <td>03.71</td>
                            <td>01.76</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn>
                        <p>Note:</p>
                    </fn>
                    <fn id="TFN05">
                        <label>1</label>
                        <p>Total score for the scale of self-efficacy expectations of changing
                            addictive behaviors;</p>
                    </fn>
                    <fn id="TFN06">
                        <label>2</label>
                        <p>Single question about self-efficacy expectations of treatment adherence;
                            SD: Standard Deviation.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
            <p>The Cox regression model outlined in <xref ref-type="table" rid="t03">Table 3</xref>
                showed evidence for associations between the two types of self-efficacy expectations
                and treatment dropout. The treatment dropout rate increased by 3% with every
                one-point increase in the score of self-efficacy expectations of changing addictive
                behaviors (<italic>HR</italic> = 1.03; <italic>p</italic> = 0.021 after adjusting
                for the variables outlined in <xref ref-type="table" rid="t01">Table 1</xref> and
                self-efficacy expectations of remaining in treatment). In this model, the dropout
                rate increased approximately two-fold with every one-point decrease in the score of
                self-efficacy expectations of remaining in treatment (<italic>HR</italic> = 2.35;
                    <italic>p</italic> = 0.034, after adjusting for the variables outlined in <xref
                    ref-type="table" rid="t01">Table 1</xref> and self-efficacy expectations of
                changing addictive behaviors).</p>
            <table-wrap id="t03">
                <label>Table 3</label>
                <caption>
                    <title>Risk of treatment dropout according to self-efficacy expectations</title>
                </caption>
            <graphic xlink:href="tb3-gt3.png"/>
                <table frame="hsides" rules="groups">
                    <tbody>
                        <tr>
                            <td>Type of self-efficacy expectations</td>
                            <td>Unadjusted HR<xref ref-type="table-fn" rid="TFN07">1</xref> (95%
                                    CI)<xref ref-type="table-fn" rid="TFN09">3</xref></td>
                            <td colspan="2">Adjusted HR<xref ref-type="table-fn" rid="TFN08"
                                    >2</xref>(95% CI)<xref ref-type="table-fn" rid="TFN09"
                                >3</xref></td>
                        </tr>
                        <tr>
                            <td>Self-efficacy expectations of changing addictive behaviors</td>
                            <td>&nbsp;</td>
                            <td colspan="2"/>
                        </tr>
                        <tr>
                            <td>&nbsp;</td>
                            <td>1.03 (1.01&#x2212;1.04)</td>
                            <td colspan="2">1.03 (1.004&#x2212;1.05)</td>
                        </tr>
                        <tr>
                            <td>&nbsp;</td>
                            <td><italic>p</italic> = 0.006</td>
                            <td colspan="2"><italic>p</italic> = 0.021</td>
                        </tr>
                        <tr>
                            <td>Self-efficacy expectations of treatment adherence</td>
                            <td>&nbsp;</td>
                            <td>&nbsp;</td>
                        </tr>
                        <tr>
                            <td>&nbsp;</td>
                            <td>2.21 (1.08&#x2212;4.51)</td>
                            <td colspan="2">2.04 (1.06&#x2212;3.92)</td>
                        </tr>
                        <tr>
                            <td>&nbsp;</td>
                            <td><italic>p</italic> = 0.03</td>
                            <td colspan="2"><italic>p</italic> = 0.034</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn>
                        <p>Note:</p>
                    </fn>
                    <fn id="TFN07">
                        <label>1</label>
                        <p>Unadjusted HR: <italic>Ratio</italic> between risk rates (hazard
                                <italic>ratio</italic>) estimated using the Cox Regression Model
                            that includes the outcome variable and the exposure variable of
                            interest;</p>
                    </fn>
                    <fn id="TFN08">
                        <label>2</label>
                        <p>Adjusted HR: For the other self-efficacy expectations in this table,
                            education level, and source of income;</p>
                    </fn>
                    <fn id="TFN09">
                        <label>3</label>
                        <p>95% CI: 95% Confidence Interval.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>The present study aimed to examine the association between motivation to continue
                psychosocial treatment for chemical dependence-related problems and adherence to
                this treatment. One hundred and fifty patients were followed up at a CAPS-AD for the
                first two months of treatment, 88.7% of whom dropped out of treatment. The following
                variables showed a significant association with the dropout risk: education, income,
                self-efficacy expectations of changing addictive behaviors, and self-efficacy
                expectations of remaining in treatment.</p>
            <p>Regarding education, the study indicates that patients with an education up to
                primary school had a higher risk of treatment dropout than did those who had
                attended college. This association corroborates findings of other studies on
                adherence to outpatient treatment for alcohol and drug use-related problems (<xref
                    ref-type="bibr" rid="B11">Micheletti et al., 2016</xref>; <xref ref-type="bibr"
                    rid="B24">Sousa, Ribeiro, Melo, Maciel, &amp; Oliveira, 2013</xref>). These
                studies showed increased difficulties in treatment adherence with decreases in level
                of education.</p>
            <p>Regarding income, the present study indicates that patients without any source of
                income have a higher risk of treatment dropout (albeit only 2%) compared with those
                who have a source of income. Difficulties in social inclusion, due to either low
                education and income or lack of social support, are a barrier to treatment adherence
                (<xref ref-type="bibr" rid="B23">Silva, Maftum, &amp; Mazza, 2014</xref>;<xref ref-type="bibr" rid="B25"> Varela,
                    Sales, Silva, &amp; Monteiro, 2016</xref>).</p>
            <p>Regarding the self-efficacy expectations (or motivation) of changing addictive
                behaviors, the results showed that less motivated participants had a higher risk of
                treatment dropout compared to other participants. A similar association was also
                found regarding the motivation to remain in treatment; that is, less motivated
                patients had more than double the risk of treatment dropout (<italic>HR</italic> =
                2.35) than did the other patients. These results are in line with other studies on
                adherence to treatment for problems related to alcohol and other chemical substances
                    (<xref ref-type="bibr" rid="B06">Ferreira et al., 2015</xref>; <xref
                    ref-type="bibr" rid="B24">Sousa et al., 2013</xref>). In these studies,
                motivation to adhere to treatment was assessed by applying the transtheoretical
                model of behavior change (<xref ref-type="bibr" rid="B17">Prochaska, DiClemente,
                    &amp; Norcross, 1992</xref>). Their findings showed that low levels of treatment
                adherence and persistence of addictive behaviors were more commonly found among
                participants allocated to the contemplation stage, and that significant increases in
                treatment adherence and changes in addictive behaviors were observed among the most
                motivated patients (typically allocated to the action stage).</p>
            <p>Limitations during the data collection of the present study should be noted and these
                may have led to data bias. The lack of a venue to perform the interviews or to
                assess the medical records forced the researchers and staff members to intercalate
                the visits, thus lengthening the research study time. Another difficulty was the
                high frequency of incomplete medical records, forcing the researchers to search for
                such data in interviews with the different reference technicians, according to their
                shift.</p>
            <p>Despite the high treatment dropout rates at the CAPS-AD, facilitating motivation to
                change addictive behaviors through treatment adherence remains the most effective
                strategy to promote general health and improve the quality of life for individuals
                and communities. This study suggests that research should focus particularly on the
                interview for admission to the treatment program as a possible approach to adjust
                patient expectations of treatment results and challenges. Health professionals
                following this approach are expected to contribute to improved adherence to the
                therapeutic process. In addition to the value of the welcome (initial approach) in
                promoting treatment adherence, the present study provides likely evidence for the
                impact of social inequality on access to healthcare, as shown by the effects of poor
                access to education and income on treatment adherence failure. Future studies with
                population-based designs will be able to further explore such evidence to provide
                data for public initiatives and policies promoting mental health.</p>
            <p>Lastly, the role of motivation in health behavioral change processes is noteworthy.
                Specifically, self-efficacy and self-determination theories (despite their
                particularities) are based on a key area of common ground in the understanding of
                human actions (<xref ref-type="bibr" rid="B20">Ryan &amp; Deci, 2017</xref>). In
                these theories, humans are regarded as active agents; that is, they have cognitive
                processes that enable them to make decisions regarding actions. Regarding health
                promotion, studies integrating the above theories aim to contribute to better
                understand the mechanisms involved in changing behaviors from risk to protection.
                For example, in adults with type 2 diabetes <italic>Mellitus</italic>, the intrinsic
                motivation to adhere to the practice of physical exercise was mediated by the
                self-efficacy expectations of performing such behavior (<xref ref-type="bibr"
                    rid="B26">Varming, Hansen, Andrésdóttir, Husted, &amp; Willaing, 2015</xref>).
                In individuals with heart disease, internal motivation and self-efficacy were
                identified as key predictors of changes in physical activity after cardiac
                rehabilitation (<xref ref-type="bibr" rid="B12">Mildestvedt, Meland, &amp; Eide,
                    2008</xref>). Therefore, (a) studies focusing on the integration between
                self-efficacy and self-determination theories in motivational interventions and (b)
                the promotion of social inclusion policies through access to education and income
                generation may represent key advances in treatment effectiveness for those seeking
                psychosocial rehabilitation. In this healthcare context, rehabilitation can be
                understood as a process whereby individuals with limitations are given an enhanced
                opportunity to restore the best possible level of autonomy in their functioning in
                the community.</p>
        </sec>
    </body>
    <back>
        <ack>
            <title>Contributors</title>
            <p>All authors contributed to the conception and design of the study, data analysis and
                final editing.</p>
        </ack>
        <fn-group>
            <title>Como citar este artigo/How to cite this article</title>
            <fn fn-type="other" id="fn01">
                <p>Leite, J. C. C., Luz, M. F. D., Walz, J. C., Filippin, L. I., Saldanha, R. P.,
                    &amp; Drachler, M. L. (2018). Motivation and adherence topsychosocial treatment
                    for alcohol and drug use-related problems. Estudos de Psicologia (Campinas),
                    35(4), 389-398. <ext-link ext-link-type="uri"
                        xlink:href="http://dx.doi.org/10.1590/1982-02752018000400006"
                        >http://dx.doi.org/10.1590/1982-02752018000400006</ext-link></p>
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