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<article article-type="case-report" dtd-version="1.0" specific-use="sps-1.8" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">
	<front>
		<journal-meta>
			<journal-id journal-id-type="publisher-id">rbccv</journal-id>
			<journal-title-group>
				<journal-title>Brazilian Journal of Cardiovascular Surgery</journal-title>
				<abbrev-journal-title abbrev-type="publisher">Braz. J. Cardiovasc.
					Surg.</abbrev-journal-title>
			</journal-title-group>
			<issn pub-type="ppub">0102-7638</issn>
			<issn pub-type="epub">1678-9741</issn>
			<publisher>
				<publisher-name>Sociedade Brasileira de Cirurgia Cardiovascular</publisher-name>
			</publisher>
		</journal-meta>
		<article-meta>
			<article-id pub-id-type="doi">10.21470/1678-9741-2024-0271</article-id>
			<article-id pub-id-type="publisher-id">00002</article-id>
			<article-categories>
				<subj-group subj-group-type="heading">
					<subject>CASE REPORT</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Sutureless Aortic Valve Implantation in a Patient with Ascending
					Aortic Aneurysm and Porcelain Aorta</article-title>
			</title-group>
			<contrib-group>
				<contrib contrib-type="author">
					<name>
						<surname>Filippa</surname>
						<given-names>Pablo A.</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff1">1</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Chaud</surname>
						<given-names>Germán J.</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="corresp" rid="c1"/>
					<xref ref-type="aff" rid="aff1b">1</xref>
					<xref ref-type="aff" rid="aff2">2</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Gundelach</surname>
						<given-names>Joaquín</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff1">1</xref>
					<xref ref-type="aff" rid="aff2">2</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Durand</surname>
						<given-names>Marcos</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff1">1</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Horta</surname>
						<given-names>Jaime</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff3">3</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Gonzalez</surname>
						<given-names>Carolina</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff3">3</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Tenelema</surname>
						<given-names>Yelka</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff1">1</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Alvarado</surname>
						<given-names>Cristóbal</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff2">2</xref>
					<xref ref-type="aff" rid="aff4">4</xref>
				</contrib>
				<contrib contrib-type="author">
					<name>
						<surname>Meriño</surname>
						<given-names>Gustavo</given-names>
					</name>
					<degrees>MD</degrees>
					<role>Substantial contributions to the conception or design of the work</role>
					<role>or the acquisition</role>
					<role>analysis</role>
					<role>or interpretation of data for the work</role>
					<role>drafting the work or revising it critically for important intellectual
						content</role>
					<role>agreement to be accountable for all aspects of the work in ensuring that
						questions related to the accuracy or integrity of any part of the work are
						appropriately investigated</role>
					<role>resolved</role>
					<role>final approval of the version to be published</role>
					<xref ref-type="aff" rid="aff1">1</xref>
				</contrib>
			</contrib-group>
			<aff id="aff1">
				<label>1</label>
				<institution content-type="normalized">Hospital Las Higueras</institution>
				<institution content-type="orgdiv1">Cardiovascular Surgery Department</institution>
				<addr-line>
					 <named-content content-type="city">Talcahuano</named-content>
				</addr-line>
				<country country="CL">Chile</country>
				<institution content-type="original">Cardiovascular Surgery Department, Hospital Las
					Higueras, Talcahuano, Chile</institution>
			</aff>
			<aff id="aff2">
				<label>2</label>
				<institution content-type="normalized">Universidad Católica de la Santísima
					Concepción</institution>
				<addr-line>
					 <named-content content-type="city">Concepción</named-content>
				</addr-line>
				<country country="CL">Chile</country>
				<institution content-type="original">Universidad Católica de la Santísima
					Concepción, Concepción, Chile</institution>
			</aff>
			<aff id="aff3">
				<label>3</label>
				<institution content-type="normalized">Hospital Las Higueras</institution>
				<institution content-type="orgdiv1">Anesthesiology Department</institution>
				<addr-line>
					 <named-content content-type="city">Talcahuano</named-content>
				</addr-line>
				<country country="CL">Chile</country>
				<institution content-type="original">Anesthesiology Department, Hospital Las
					Higueras, Talcahuano, Chile</institution>
			</aff>
			<aff id="aff4">
				<label>4</label>
				<institution content-type="normalized">Hospital Las Higueras</institution>
				<institution content-type="orgdiv1">Research and Statistical
					Department</institution>
				<addr-line>
					 <named-content content-type="city">Talcahuano</named-content>
				</addr-line>
				<country country="CL">Chile</country>
				<institution content-type="original">Research and Statistical Department, Hospital
					Las Higueras, Talcahuano, Chile</institution>
			</aff>
			<aff id="aff1b">
				<label>1</label>
				<institution content-type="normalized">Hospital Las Higueras</institution>
				<institution content-type="orgdiv1">Cardiovascular Surgery Department</institution>
				<addr-line>
					 <named-content content-type="city">Talcahuano</named-content>
				</addr-line>
				<country country="CL">Chile</country>
				<institution content-type="original">Cardiovascular Surgery Department, Hospital Las
					Higueras, Talcahuano, Chile</institution>
					<email>germanchaud@gmail.com</email>
			</aff>
			<author-notes>
				<corresp id="c1"><label>Correspondence Address:</label>Germán J. Chaud, <ext-link
						ext-link-type="uri" xlink:href="https://orcid.org/0000-0003-0256-3360"
						>https://orcid.org/0000-0003-0256-3360</ext-link>, Department of Cardiac
					Surgery, Hospital Las Higueras, Alto Horno 777, Talcahuano, Chile, Zip Code:
					4260000, E-mail: <email>germanchaud@gmail.com</email>
				</corresp>
				<fn fn-type="conflict">
					<p><bold>No conflict of interest.</bold></p>
				</fn>
			</author-notes>
			<!--<pub-date date-type="pub" publication-format="electronic">
				<day>04</day>
				<month>08</month>
				<year>2025</year>
			</pub-date>
			<pub-date date-type="collection" publication-format="electronic">
				<year>2025</year>
			</pub-date>-->
			<pub-date pub-type="epub-ppub">
				<year>2025</year>
			</pub-date>
			<volume>40</volume>
			<issue>6</issue>
			<elocation-id>e20240271</elocation-id>
			<history>
				<date date-type="received">
					<day>01</day>
					<month>08</month>
					<year>2024</year>
				</date>
				<date date-type="accepted">
					<day>18</day>
					<month>12</month>
					<year>2024</year>
				</date>
			</history>
			<permissions>
				<license license-type="open-access"
					xlink:href="https://creativecommons.org/licenses/by/4.0/" xml:lang="en">
					<license-p>This is an Open Access article distributed under the terms of the
						Creative Commons Attribution License, which permits unrestricted use,
						distribution, and reproduction in any medium, provided the original work is
						properly cited.</license-p>
				</license>
			</permissions>
			<abstract>
				<title>ABSTRACT</title>
				<p>Implanting sutureless aortic valves enables a reduction in surgical times and
					related complications. Nonetheless, their application has been limited in cases
					involving aortic aneurysms due to anchor system concerns. We present a case of
					aortic valve replacement using a Perceval™ sutureless aortic valve in a patient
					with stage IV chronic kidney disease, an ascending aortic aneurysm, and a
					porcelain aorta. The procedure was performed concomitantly with coronary artery
					bypass grafting involving two grafts, as well as ascending aorta and hemiarch
					replacement. This case underscores the critical importance of time efficiency,
					technical modifications for valve implantation, and strategic surgical planning
					to mitigate potential intraoperative and postoperative complications.</p>
			</abstract>
			<kwd-group xml:lang="en">
				<title>Keywords:</title>
				<kwd>Aorta Ascending Aneurysm</kwd>
				<kwd>Aortic Aneurysm</kwd>
				<kwd>Dental Porcelain</kwd>
				<kwd>Postoperative Complications</kwd>
			</kwd-group>
			<counts>
				<fig-count count="2"/>
				<table-count count="1"/>
				<equation-count count="0"/>
				<ref-count count="6"/>
			</counts>
		</article-meta>
	</front>
	<body>
		<sec sec-type="intro">
			<title>INTRODUCTION</title>
			<p><table-wrap id="t1">
				<table frame="hsides" rules="groups">
					<thead>
						<tr>
							<th align="left" colspan="2" valign="top">Abbreviations, Acronyms &amp;
								Symbols</th>
						</tr>
					</thead>
					<tbody>
						<tr>
							<td align="left" valign="top">CT</td>
							<td align="center" valign="top">= Computed tomography</td>
						</tr>
						<tr>
							<td align="left" valign="top">STJ</td>
							<td align="center" valign="top">= Sinotubular junction</td>
						</tr>
					</tbody>
				</table>
			</table-wrap>
		</p>
			<p>Implantation of sutureless aortic valves enables quicker procedures, thereby reducing
				surgical times and associated risks<sup>[<xref ref-type="bibr" rid="B1"
					>1</xref>]</sup>. However, historically, their application has been limited by
				the presence of concomitant aortic root and sinotubular junction (STJ) aneurysms,
				necessitating a STJ/annulus ratio &lt; 1.3<sup>[<xref ref-type="bibr" rid="B2"
						>2</xref>]</sup>. In this paper, we highlight the challenging application of
				a sutureless aortic valve in a patient with a severely calcified ascending aortic
				aneurysm and concomitant coronary artery disease. This case underscores the
				feasibility of utilizing sutureless valve technology in complex aortic pathology,
				which expands the potential indications for its use in cases where it has
				historically controverted.</p>
		</sec>
		<sec sec-type="cases">
			<title>CASE PRESENTATION</title>
			<p>A 70-year-old female patient, with a medical history including stage IV kidney
				dysfunction, hypertension, type II diabetes, former smoking habits, and a previous
				stroke resulting in residual mild right hemiparesis, was transferred to our
				institution due to symptomatic severe aortic insufficiency in a New York Heart
				Association III/IV status, evidenced by transthoracic echocardiography with a
				regurgitant jet occupying 60% of the left ventricular outflow tract and a left
				ventricular ejection fraction of 55%. Preoperative computed tomography (CT) scan
				revealed a porcelain aorta with concurrent aneurysms of the ascending portion (60
				mm) and proximal arch (48 mm), while the aortic root appeared normal (<xref
					ref-type="fig" rid="f1">Figure 1A</xref>). Coronary angiography indicated 80%
				stenosis in the main trunk and 70% stenosis in the proximal left anterior descending
				artery (<xref ref-type="fig" rid="f1">Figure 1B</xref>). The patient's case was
				discussed by a Heart Team, and a percutaneous strategy was declined due to the
				presence of an ascending aortic aneurysm and left main coronary artery stenosis. The
				study was approved by the hospital ethics committee (SSMOriente190324) and informed
				consent was obtained.</p>
			<p>
				<fig id="f1">
					<label>Fig. 1</label>
					<caption>
						<title>(A) Preoperative computed tomography scan showing ascending aortic
							aneurysm with porcelain aorta. (B) Coronary angiogram with main trunk
							stenosis (arrow).</title>
					</caption>
					<graphic xlink:href="0102-7638-rbccv-40-06-e20240271-gf01.jpg"/>
				</fig>
			</p>
			<sec>
				<title>Surgical Technique</title>
				<p>The surgery was approached by median sternotomy. Central aortic cannulation was
					guided by epiaortic echocardiography and performed using the Seldinger
					technique. The patient was gradually cooled to 30°C, and a 12 Fr arterial
					cannula was introduced into the brachiocephalic trunk to facilitate antegrade
					cerebral perfusion. Upon reaching the target temperature, circulatory arrest was
					initiated, and myocardial protection was achieved by administering Del Nido
					cardioplegia retrogradely and directly into the coronary ostia. Subsequently,
					the ascending aorta and hemiarch were replaced with a 32 mm Dacron® graft
					secured with 4-0 polypropylene sutures and reinforced with Teflon™ felt. The
					Dacron® prothesis was then cannulated and cross-clamped, starting systemic
					perfusion. During rewarming, a distal second obtuse marginal coronary bypass
					graft was constructed using a saphenous vein. The aortic valve was then excised,
					and proximal aortic-Dacron® suturing commenced at the posterior STJ level,
					facilitating subsequent implantation of a size M sutureless Perceval™ aortic
					valve (LivaNova PLC, London, United Kingdom) (<xref ref-type="fig" rid="f2"
						>Figure 2A</xref>). Completion of the proximal aortic-Dacron® suture
					anteriorly was followed by anastomosis of the proximal end of the venous graft
					into the Dacron® prosthesis. Finally, a left internal mammary artery to left
					anterior descending artery anastomosis was performed (<xref ref-type="fig"
						rid="f2">Figure 2B</xref>).</p>
				<p>
					<fig id="f2">
						<label>Fig. 2</label>
						<caption>
							<title>Intraoperative view showing Dacron® cannulation (white star) and
								12 Fr brachiocephalic arterial cannula (white arrow) (A) with
								posterior aortic-Dacron® sinotubular junction suture performed and
								sutureless valve deployed (white head arrow); (B) completion of
								anterior aortic-Dacron® anastomosis and coronary bypasses (white
								head arrow).</title>
						</caption>
						<graphic xlink:href="0102-7638-rbccv-40-06-e20240271-gf02.jpg"/>
					</fig>
				</p>
				<p>Cardiopulmonary bypass and aortic cross-clamping durations were recorded at 125
					and 62 minutes, respectively, with a circulatory arrest period of 26 minutes.
					Postoperative transesophageal echocardiography revealed a mean aortic gradient
					of 2.9 mmHg and no evidence of perivalvular leak. The immediate postoperative
					course was notable for severe vasoplegia and acute kidney dysfunction, which
					resolved to baseline levels. The patient was discharged on day eight without
					further complications. At the 10-month follow-up, the patient remains
					asymptomatic, with a CT scan revealing no surgical complications or valve
					migration.</p>
			</sec>
		</sec>
		<sec sec-type="discussion">
			<title>DISCUSSION</title>
			<p>The use of rapid deployment aortic valves had been contraindicated in patients with
				root and ascending aortic aneurysms due to concerns regarding the anchor
						system<sup>[<xref ref-type="bibr" rid="B3">3</xref>]</sup>. Nonetheless, a
				handful of published cases have demonstrated the feasibility and excellent outcomes
				of this approach<sup>[<xref ref-type="bibr" rid="B2">2</xref>-<xref ref-type="bibr"
						rid="B5">5</xref>]</sup>. This case report highlights several key points.
				Sutureless valves have been shown to reduce normal cardiopulmonary bypass times by
				up to 40%, making them a valuable tool in the treatment of severely ill
						patients<sup>[<xref ref-type="bibr" rid="B4">4</xref>]</sup>. These saved
				minutes can be invaluable, especially in combined procedures. The optimal sequence
				for valve deployment may vary depending on the patient's specific situation. One
				approach involves creating a new STJ with aortic-Dacron® anastomosis before valve
				deployment. Alternatively, starting with the posterior wall of the aortic-Dacron®
				anastomosis also allows for proper positioning of the valve before completing the
				anterior portion of the anastomosis in usual fashion.</p>
			<p>On the other hand, a porcelain aorta is a predictor of mortality and stroke and
				presents additional challenges for surgical intervention, including arterial
				cannulation and aortic clamping<sup>[<xref ref-type="bibr" rid="B6">6</xref>]</sup>.
				Epiaortic echocardiography is an invaluable tool at time of cannulation to find the
				perfect spot in severe aortic calcification. Planning for cerebral protection and
				avoiding aortic cross-clamping are emphasized to reduce the risk of distal
				embolization.</p>
		</sec>
		<sec sec-type="conclusions">
			<title>CONCLUSION</title>
			<p>While a limited number of cases have been published, this case underscores the
				importance of rapid valve deployment in challenging patients and its feasibility
				alongside concomitant ascending aortic replacement without valve migration.
				Moreover, dealing with a porcelain aorta adds complexity and highlights the
				importance of meticulous planning and teamwork. Nevertheless, larger series are
				still needed to confirm the efficacy of sutureless valves in such scenarios.</p>
		</sec>
	</body>
	<back>
		<fn-group>
			<fn fn-type="other">
				<p>This study was carried out at the Cardiovascular Surgery Department, Hospital Las
					Higueras, Talcahuano, Chile.</p>
			</fn>
			<fn fn-type="other">
				<p><bold>No financial support.</bold></p>
			</fn>
		</fn-group>
		<ref-list>
			<title>REFERENCES</title>
			<ref id="B1">
				<label>1</label>
				<mixed-citation>Santarpino G, Pfeiffer S, Concistré G, Grossmann I, Hinzmann M,
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					surgical time: does it also result in improved outcome? Ann Thorac Surg.
					2013;96(1):77-81; discussion 81-2.
					doi:10.1016/j.athoracsur.2013.03.083.</mixed-citation>
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						<name>
							<surname>Santarpino</surname>
							<given-names>G</given-names>
						</name>
						<name>
							<surname>Pfeiffer</surname>
							<given-names>S</given-names>
						</name>
						<name>
							<surname>Concistré</surname>
							<given-names>G</given-names>
						</name>
						<name>
							<surname>Grossmann</surname>
							<given-names>I</given-names>
						</name>
						<name>
							<surname>Hinzmann</surname>
							<given-names>M</given-names>
						</name>
						<name>
							<surname>Fischlein</surname>
							<given-names>T.</given-names>
						</name>
					</person-group>
					<article-title>The perceval s aortic valve has the potential of shortening
						surgical time: does it also result in improved outcome?</article-title>
					<source>Ann Thorac Surg</source>
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